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ArgP,DnaA,ppGpp regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
ArgP Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator ArgP, IciA
Gene name(s): argP
Functional conformation(s): ArgP-lysine , ArgP , ArgP-arginine
Coregulator(s): ArgP, CRP, DnaA, FNR, Fis, Fur, H-NS, Lrp, LysR, Nac, NrdR, PhoB, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
DnaA Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): chromosomal replication initiator protein DnaA, chromosomal replication initiator protein/DNA-binding transcriptional dual regulator DnaA
Gene name(s): dnaA
Functional conformation(s): DnaA , DnaA-ATP
Coregulator(s): ArcA, ArgP, CRP, CytR, DnaA, FNR, Fis, H-NS, LexA, MarA, NrdR, PurR, Rob, SoxS, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY ArgP,DnaA,ppGpp Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
ArgP activator DnaA repressor ppGpp inhibition    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
DnaA-ATP repressor dnaAp1 recF , dnaN , dnaA 3883935 3883943 23.0 aagtcctgtgGATAAATCGggaaaatctg [BPP]
[GEA]
[1]
[2]
ArgP activator dnaAp1 recF , dnaN , dnaA 3884001 3884020 -49.5 gtcattaaatTTTCCAATATGCGGCGTAAAtcgtgcccgc [BPP]
[GEA]
[IC]
[1]
[3]
[2]
[4]
ArgP activator dnaAp1 recF , dnaN , dnaA 3884021 3884040 -69.5 taagccaattTTTGTCTATGGTCATTAAATtttccaatat [BPP]
[GEA]
[IC]
[1]
[3]
[2]
[4]
ArgP activator dnaAp1 recF , dnaN , dnaA 3883733 3883752 219.5 tcattatcgaCTTTTGTTCGAGTGGAGTCCgccgtgtcac [BPP]
[GEA]
[IC]
[1]
[3]
[2]
[4]

Evidence: [BPP] Binding of purified proteins
[GEA] Gene expression analysis
[IC] Inferred by curator
Reference(s): [1] Lee Y., et al., 1997
[2] Lee YS., et al., 1996
[3] Lee YS., et al., 1997
[4] Marbaniang CN., et al., 2011



Reference(s)    

 [1] Lee Y., Lee H., Yim J., Hwang D., 1997, The binding of two dimers of IciA protein to the dnaA promoter 1P element enhances the binding of RNA polymerase to the dnaA promoter 1P., Nucleic Acids Res 25(17):3486-9

 [2] Lee YS., Kim H., Hwang DS., 1996, Transcriptional activation of the dnaA gene encoding the initiator for oriC replication by IciA protein, an inhibitor of in vitro oriC replication in Escherichia coli., Mol Microbiol 19(2):389-96

 [3] Lee YS., Hwang DS., 1997, Occlusion of RNA polymerase by oligomerization of DnaA protein over the dnaA promoter of Escherichia coli., J Biol Chem 272(1):83-8

 [4] Marbaniang CN., Gowrishankar J., 2011, Role of ArgP (IciA) in Lysine-Mediated Repression in Escherichia coli., J Bacteriol 193(21):5985-96


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