RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


BolA regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
BolA      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator BolA
Gene name(s): bolA
Functional conformation(s): BolA
Coregulator(s): BolA
Summary: TF Summary ...[more]

REGULATION EXERTED BY BolA Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
BolA dual    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
BolA dual dacCp dacC         [GEA]
[IMP]
[1]
[2]
BolA dual ampCp ampC         [GEA]
[IMP]
[2]
BolA dual dacCp dacC         [GEA]
[IMP]
[1]
[2]
BolA dual ampCp ampC         [GEA]
[IMP]
[2]
BolA repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
BolA repressor mreBp1 mreD , mreC , mreB         [BPP]
[GEA]
[3]

Evidence: [GEA] Gene expression analysis
[IMP] Inferred from mutant phenotype
[BPP] Binding of purified proteins
Reference(s): [1] Guinote IB., et al., 2011
[2] Santos JM., et al., 2002
[3] Freire P., et al., 2009



Reference(s)    

 [1] Guinote IB., Matos R., Freire P., Arraiano C., 2011, BolA Affects Cell Growth, and Binds to the Promoters of Penicillin-Binding Proteins 5 and 6 and Regulates Their Expression., J Microbiol Biotechnol 21(3):243-51

 [2] Santos JM., Lobo M., Matos AP., De Pedro MA., Arraiano CM., 2002, The gene bolA regulates dacA (PBP5), dacC (PBP6) and ampC (AmpC), promoting normal morphology in Escherichia coli., Mol Microbiol 45(6):1729-40

 [3] Freire P., Moreira RN., Arraiano CM., 2009, BolA inhibits cell elongation and regulates MreB expression levels., J Mol Biol 385(5):1345-51


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