RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


H-NS,Lrp,StpA regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
H-NS      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): BglY, Cur, DNA-binding protein HLP-II (HU, BH2, HD, NS), DNA-binding transcriptional dual regulator H-NS, Drc, DrdX, Drs, FimG, Hns, HnsA, Irk, MsyA, OsmZ, PilG, TopS, TopX, VirR
Gene name(s): hns
Functional conformation(s): H-NS
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, BasR, CRP, CadC, CaiF, CdaR, CpxR, Cra, CsgD, CspA, CysB, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, FNR, Fis, FlhDC, FliZ, Fur, GadE, GadW, GadX, GalR, GalS, GlaR, GutM, H-NS, HU, HdfR, HypT, IHF, LacI, LeuO, LrhA, Lrp, MarA, MatA, McbR, MlrA, MntR, MqsA, NagC, NanR, NarL, NarP, NhaR, NrdR, NsrR, OmpR, OxyR, PhoB, PhoP, QseB, RcdA, RcsB, Rob, RstA, RutR, SdiA, SlyA, SoxS, SrlR, StpA, SutR, TorR, UvrY, YdeO, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
Lrp Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Sensing external and internal signals
Synonym(s): AlsB, DNA-binding transcriptional dual regulator Lrp, Ihb, LivR, Lrs, Lss, LstR, Mbf, OppI, RblA
Gene name(s): lrp
Functional conformation(s): Lrp , Lrp-leucine
Coregulator(s): AcrR, Ada, AdiY, AidB, ArcA, ArgP, ArgR, CRP, CadC, CpxR, Cra, DksA, DksA-ppGpp, EnvY, FNR, Fis, FliZ, Fur, GadE, GadW, GadX, GcvA, GlaR, H-NS, HU, HdfR, IHF, LrhA, Lrp, MarA, Mlc, ModE, Nac, NarL, NhaR, NsrR, OmpR, PhoP, PurR, RcsB, Rob, SoxS, StpA, TorR, YeiL, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
StpA      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional repressor StpA with RNA chaperone activity, H-NS-like DNA-binding transcriptional repressor with RNA chaperone activity, HnsB
Gene name(s): stpA
Functional conformation(s): StpA
Coregulator(s): CRP, Fis, H-NS, LeuO, Lrp, RcsB, StpA
Summary: TF Summary ...[more]

REGULATION EXERTED BY H-NS,Lrp,StpA Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
H-NS repressor Lrp activator StpA repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
Lrp activator stpAp1 stpA 2799068 2799083 -539.0 gcattttcgcATAGCGTATATCGCTGgctatgacta [BCE]
[BPP]
[GEA]
[HIBSCS]
[1]
[2]
[3]
Lrp activator stpAp1 stpA 2799019 2799034 -490.0 aaatttttatTTAGTCAGTTTTTGTAgataaaatat [BCE]
[BPP]
[GEA]
[HIBSCS]
[1]
[2]
[3]
Lrp activator stpAp1 stpA 2798636 2798650 -107.0 aatatataatCTTGAAATTATTCTGagagtttcag [BCE]
[BPP]
[GEA]
[HIBSCS]
[1]
[3]
StpA repressor stpAp1 stpA         [GEA] [4]
H-NS repressor stpAp1 stpA         [BCE]
[BPP]
[GEA]
[1]
[3]

Evidence: [BCE] Binding of cellular extracts
[BPP] Binding of purified proteins
[GEA] Gene expression analysis
[HIBSCS] Human inference based on similarity to consensus sequences
Reference(s): [1] Free A., et al., 1997
[2] Ihara K., et al., 2017
[3] Sonden B., et al., 1996
[4] Gueune H., et al., 2008



Reference(s)    

 [1] Free A., Dorman CJ., 1997, The Escherichia coli stpA gene is transiently expressed during growth in rich medium and is induced in minimal medium and by stress conditions., J Bacteriol 179(3):909-18

 [2] Ihara K., Sato K., Hori H., Makino Y., Shigenobu S., Ando T., Isogai E., Yoneyama H., 2017, Expression of the alaE gene is positively regulated by the global regulator Lrp in response to intracellular accumulation of l-alanine in Escherichia coli., J Biosci Bioeng

 [3] Sonden B., Uhlin BE., 1996, Coordinated and differential expression of histone-like proteins in Escherichia coli: regulation and function of the H-NS analog StpA., EMBO J 15(18):4970-80

 [4] Gueune H., Durand MJ., Thouand G., DuBow MS., 2008, The ygaVP genes of Escherichia coli form a tributyltin-inducible operon., Appl Environ Microbiol 74(6):1954-8


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