RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


H-NS,Lrp,NhaR,RcsB regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
H-NS      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): BglY, Cur, DNA-binding protein HLP-II (HU, BH2, HD, NS), DNA-binding transcriptional dual regulator H-NS, Drc, DrdX, Drs, FimG, Hns, HnsA, Irk, MsyA, OsmZ, PilG, TopS, TopX, VirR
Gene name(s): hns
Functional conformation(s): H-NS
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, BasR, CRP, CadC, CaiF, CdaR, CpxR, Cra, CsgD, CspA, CysB, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, FNR, Fis, FlhDC, FliZ, Fur, GadE, GadW, GadX, GalR, GalS, GlaR, GutM, H-NS, HU, HdfR, HypT, IHF, LacI, LeuO, LrhA, Lrp, MarA, MatA, McbR, MlrA, MntR, MqsA, NagC, NanR, NarL, NarP, NhaR, NrdR, NsrR, OmpR, OxyR, PhoB, PhoP, QseB, RcdA, RcsB, Rob, RstA, RutR, SdiA, SlyA, SoxS, SrlR, StpA, SutR, TorR, UvrY, YdeO, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
RcsB Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional activator RcsB, RcsB response regulator
Gene name(s): rcsB
Functional conformation(s): RcsB-Pasp56
Coregulator(s): AcrR, AdiY, ArcA, BasR, CRP, CpxR, Cra, CsgD, EvgA, FNR, Fis, FliZ, Fur, GadE, GadW, GadX, GlrR, H-NS, HdfR, IHF, LeuO, LexA, LrhA, Lrp, MarA, MatA, MlrA, MqsA, NagC, NarL, NarP, NhaR, NtrC, OmpR, PhoP, QseB, RcdA, RcsB, RstA, StpA, TorR, UvrY, YdeO, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
NhaR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External sensing using transported metabolites
Synonym(s): AntO, DNA-binding transcriptional activator NhaR, YaaB
Gene name(s): nhaR
Functional conformation(s): NhaR , NhaR-Na+
Coregulator(s): H-NS, Lrp, NhaR, OmpR, RcsB
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
Lrp Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Sensing external and internal signals
Synonym(s): AlsB, DNA-binding transcriptional dual regulator Lrp, Ihb, LivR, Lrs, Lss, LstR, Mbf, OppI, RblA
Gene name(s): lrp
Functional conformation(s): Lrp , Lrp-leucine
Coregulator(s): AcrR, Ada, AdiY, AidB, ArcA, ArgP, ArgR, CRP, CadC, CpxR, Cra, DksA, DksA-ppGpp, EnvY, FNR, Fis, FliZ, Fur, GadE, GadW, GadX, GcvA, GlaR, H-NS, HU, HdfR, IHF, LrhA, Lrp, MarA, Mlc, ModE, Nac, NarL, NhaR, NsrR, OmpR, PhoP, PurR, RcsB, Rob, SoxS, StpA, TorR, YeiL, YjjQ, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY H-NS,Lrp,NhaR,RcsB Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
H-NS repressor Lrp repressor NhaR activator RcsB activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
RcsB-Pasp56 activator osmCp1 osmC 1556548 1556561 -41.5 cggattttatTCGGAATATCCTGCttatcctcgt [BPP]
[GEA]
[SM]
[1]
[2]
Lrp repressor osmCp1 osmC 1556537 1556551 -52.0 aatattttcgCCGGATTTTATTCGGaatatcctgc [BPP]
[GEA]
[HIBSCS]
[SM]
[3]
NhaR-Na+ activator osmCp1 osmC 1556546 1556563 -42.0 gccggattttATTCGGAATATCCTGCTTatcctcgtgc [BCE]
[GEA]
[SM]
[4]
[5]
H-NS repressor osmCp1 osmC         [GEA] [3]

Evidence: [BPP] Binding of purified proteins
[GEA] Gene expression analysis
[SM] Site mutation
[HIBSCS] Human inference based on similarity to consensus sequences
[BCE] Binding of cellular extracts
Reference(s): [1] Davalos-Garcia M., et al., 2001
[2] Francez-Charlot A., et al., 2005
[3] Bouvier J., et al., 1998
[4] Sturny R., et al., 2003
[5] Toesca I., et al., 2001



Reference(s)    

 [1] Davalos-Garcia M., Conter A., Toesca I., Gutierrez C., Cam K., 2001, Regulation of osmC gene expression by the two-component system rcsB-rcsC in Escherichia coli., J Bacteriol 183(20):5870-6

 [2] Francez-Charlot A., Castanie-Cornet MP., Gutierrez C., Cam K., 2005, Osmotic Regulation of the Escherichia coli bdm (Biofilm-Dependent Modulation) Gene by the RcsCDB His-Asp Phosphorelay., J Bacteriol 187(11):3873-7

 [3] Bouvier J., Gordia S., Kampmann G., Lange R., Hengge-Aronis R., Gutierrez C., 1998, Interplay between global regulators of Escherichia coli: effect of RpoS, Lrp and H-NS on transcription of the gene osmC., Mol Microbiol 28(5):971-80

 [4] Sturny R., Cam K., Gutierrez C., Conter A., 2003, NhaR and RcsB independently regulate the osmCp1 promoter of Escherichia coli at overlapping regulatory sites., J Bacteriol 185(15):4298-304

 [5] Toesca I., Perard C., Bouvier J., Gutierrez C., Conter A., 2001, The transcriptional activator NhaR is responsible for the osmotic induction of osmC(p1), a promoter of the stress-inducible gene osmC in Escherichia coli., Microbiology 147(Pt 10):2795-803


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