RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


CRP,H-NS,MqsA,ppGpp regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP-cAMP , CRP
Coregulator(s): AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BtsR, CRP, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FucR, Fur, GadE, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsB, RhaR, RhaS, Rob, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YiaJ, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
H-NS      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): BglY, Cur, DNA-binding protein HLP-II (HU, BH2, HD, NS), DNA-binding transcriptional dual regulator H-NS, Drc, DrdX, Drs, FimG, Hns, HnsA, Irk, MsyA, OsmZ, PilG, TopS, TopX, VirR
Gene name(s): hns
Functional conformation(s): H-NS
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, BasR, CRP, CadC, CaiF, CdaR, CpxR, Cra, CsgD, CspA, CysB, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, FNR, Fis, FlhDC, FliZ, Fur, GadE, GadW, GadX, GalR, GalS, GlaR, GutM, H-NS, HU, HdfR, HypT, IHF, LacI, LeuO, LrhA, Lrp, MarA, MatA, McbR, MlrA, MntR, MqsA, NagC, NanR, NarL, NarP, NhaR, NrdR, NsrR, OmpR, OxyR, PhoB, PhoP, QseB, RcdA, RcsB, Rob, RstA, RutR, SdiA, SlyA, SoxS, SrlR, StpA, SutR, TorR, UvrY, YdeO, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
MqsA Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): YgiT, antitoxin of the MqsRA toxin-antitoxin system / DNA-binding transcriptional repressor MqsA
Gene name(s): mqsA
Functional conformation(s): MqsA
Coregulator(s): ArcA, BasR, CRP, CpxR, Cra, CsgD, FliZ, Fur, GadX, H-NS, IHF, MlrA, MqsA, OmpR, RcdA, RcsB, RstA, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY CRP,H-NS,MqsA,ppGpp Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CRP activator H-NS activator MqsA repressor ppGpp activation    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
MqsA repressor cspDp cspD 922800 922818 -132.5 atgatagataACTATCATCTATCGTTGGCatcagcgaca [BPP]
[GEA]
[1]
MqsA repressor cspDp cspD 922567 922585 101.5 gaagcatggaAAAGGGTACTGTTAAGTGGttcaacaatg [BPP]
[GEA]
[1]
CRP-cAMP activator cspDp cspD 922749 922770 -83.5 ttcctgtcaaTAGCGTTAACTGCTTCAAATTTttgattcata [AIBSCS]
[BPP]
[GEA]
[SM]
[2]
CRP-cAMP activator cspDp cspD 922778 922799 -112.5 tatcgttggcATCAGCGACATCTGTCACATTCctgtcaatag [BPP]
[GEA]
[HIBSCS]
[SM]
[2]
H-NS activator cspDp cspD         [GEA] [3]

Evidence: [BPP] Binding of purified proteins
[GEA] Gene expression analysis
[AIBSCS] Automated inference based on similarity to consensus sequences
[SM] Site mutation
[HIBSCS] Human inference based on similarity to consensus sequences
Reference(s): [1] Kim Y., et al., 2010
[2] Uppal S., et al., 2014
[3] Yamanaka K., et al., 1997



Reference(s)    

 [1] Kim Y., Wang X., Zhang XS., Grigoriu S., Page R., Peti W., Wood TK., 2010, Escherichia coli toxin/antitoxin pair MqsR/MqsA regulate toxin CspD., Environ Microbiol 12(5):1105-21

 [2] Uppal S., Shetty DM., Jawali N., 2014, Cyclic AMP receptor protein regulates cspD, a bacterial toxin gene, in Escherichia coli., J Bacteriol 196(8):1569-77

 [3] Yamanaka K., Inouye M., 1997, Growth-phase-dependent expression of cspD, encoding a member of the CspA family in Escherichia coli., J Bacteriol 179(16):5126-30


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