RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


CRP,ExuR,OxyR,UxuR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP-cAMP , CRP
Coregulator(s): AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BtsR, CRP, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FucR, Fur, GadE, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsB, RhaR, RhaS, Rob, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YiaJ, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
OxyR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator OxyR, MomR, Mor, bifunctional regulatory protein sensor for oxidative stress
Gene name(s): oxyR
Functional conformation(s): OxyR
Coregulator(s): CRP, ExuR, FNR, Fis, Fur, H-NS, IHF, IscR, MarA, MetJ, MetR, MntR, NarL, NarP, NsrR, OxyR, Rob, SoxS, UxuR, Zur
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
ExuR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External sensing using transported metabolites
Synonym(s): DNA-binding transcriptional repressor ExuR, negative regulator of exu regulon, exuT, uxaAC, and uxuB
Gene name(s): exuR
Functional conformation(s): ExuR-α-D-glucuronate , ExuR , ExuR-α-D-galacturonate, α-D-glucuronate
Coregulator(s): CRP, DpiA, ExuR, FNR, OxyR, UxuR
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
UxuR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional repressor UxuR
Gene name(s): uxuR
Functional conformation(s): UxuR-D-fructuronate , UxuR-α-D-glucuronate-α-D-galacturonate , UxuR
Coregulator(s): CRP, ExuR, OxyR, UidR, UxuR
Summary: TF Summary ...[more]

REGULATION EXERTED BY CRP,ExuR,OxyR,UxuR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CRP activator ExuR repressor OxyR repressor UxuR repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CRP-cAMP activator uxuAp uxuA , uxuB 4551365 4551386 -142.5 ggtcaaccatTGTTGCGATGAATGTCACATCCtctgatcaat [AIBSCS]
[GEA]
[1]
[2]
[3]
[4]
CRP-cAMP activator uxuAp uxuA , uxuB 4551450 4551471 -57.5 agagtgaaatTCTTGTGATGTGGTTAACCAATttcagaattc [BPP]
[HIBSCS]
[5]
[3]
ExuR repressor uxuAp uxuA , uxuB 4551350 4551367 -159.5 tatgttatgtAAATTGGTCAACCATTGTtgcgatgaat [GEA] [6]
[3]
ExuR repressor uxuAp uxuA , uxuB 4551456 4551473 -53.5 aaattcttgtGATGTGGTTAACCAATTTcagaattcgg [GEA]
[HIBSCS]
[6]
[3]
OxyR repressor uxuAp uxuA , uxuB 4551478 4551494 -32.0 caatttcagaATTCGGGTTGACATGTCttaccaaaag [GEA]
[HIBSCS]
[7]
OxyR repressor uxuAp uxuA , uxuB 4551456 4551472 -54.0 aaattcttgtGATGTGGTTAACCAATTtcagaattcg [GEA]
[HIBSCS]
[7]
UxuR repressor uxuAp uxuA , uxuB 4551350 4551367 -159.5 tatgttatgtAAATTGGTCAACCATTGTtgcgatgaat [BPP]
[GEA]
[HIBSCS]
[SM]
[1]
[3]
UxuR repressor uxuAp uxuA , uxuB 4551456 4551473 -53.5 aaattcttgtGATGTGGTTAACCAATTTcagaattcgg [GEA]
[HIBSCS]
[8]
[9]
[6]
[3]

Evidence: [AIBSCS] Automated inference based on similarity to consensus sequences
[GEA] Gene expression analysis
[BPP] Binding of purified proteins
[HIBSCS] Human inference based on similarity to consensus sequences
[SM] Site mutation
Reference(s): [1] Bates Utz C., et al., 2004
[2] Klemm P., et al., 1996
[3] Rodionov DA., et al., 2000
[4] Zheng D., et al., 2004
[5] Blanco C., et al., 1986
[6] Robert-Baudouy J., et al., 1981
[7] Zheng M., et al., 2001
[8] Ritzenthaler P., et al., 1985
[9] Ritzenthaler P., et al., 1982



Reference(s)    

 [1] Bates Utz C., Nguyen AB., Smalley DJ., Anderson AB., Conway T., 2004, GntP is the Escherichia coli Fructuronic acid transporter and belongs to the UxuR regulon., J Bacteriol 186(22):7690-6

 [2] Klemm P., Tong S., Nielsen H., Conway T., 1996, The gntP gene of Escherichia coli involved in gluconate uptake., J Bacteriol 178(1):61-7

 [3] Rodionov DA., Mironov AA., Rakhmaninova AB., Gelfand MS., 2000, Transcriptional regulation of transport and utilization systems for hexuronides, hexuronates and hexonates in gamma purple bacteria., Mol Microbiol 38(4):673-83

 [4] Zheng D., Constantinidou C., Hobman JL., Minchin SD., 2004, Identification of the CRP regulon using in vitro and in vivo transcriptional profiling., Nucleic Acids Res 32(19):5874-93

 [5] Blanco C., Ritzenthaler P., Kolb A., 1986, The regulatory region of the uxuAB operon in Escherichia coli K12., Mol Gen Genet 202(1):112-9

 [6] Robert-Baudouy J., Portalier R., Stoeber F., 1981, Regulation of hexuronate system genes in Escherichia coli K-12: multiple regulation of the uxu operon by exuR and uxuR gene products., J Bacteriol 145(1):211-20

 [7] Zheng M., Wang X., Templeton LJ., Smulski DR., LaRossa RA., Storz G., 2001, DNA microarray-mediated transcriptional profiling of the Escherichia coli response to hydrogen peroxide., J Bacteriol 183(15):4562-70

 [8] Ritzenthaler P., Blanco C., Mata-Gilsinger M., 1985, Genetic analysis of uxuR and exuR genes: evidence for ExuR and UxuR monomer repressors interactions., Mol Gen Genet 199(3):507-11

 [9] Ritzenthaler P., Mata-Gilsinger M., 1982, Use of in vitro gene fusions to study the uxuR regulatory gene in Escherichia coli K-12: direction of transcription and regulation of its expression., J Bacteriol 150(3):1040-7


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