RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


BasR,MarA,PutA regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
MarA Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): CfxB, DNA-binding transcriptional dual regulator MarA, InaR, NfxC, NorB, SoxQ
Gene name(s): marA
Functional conformation(s): MarA
Coregulator(s): AcrR, ArcA, BasR, CRP, CpxR, Cra, DnaA, EnvR, FNR, Fis, FliZ, Fur, GadE, GadW, GadX, H-NS, HU, IHF, Lrp, MarA, MarR, MprA, OmpR, OxyR, PhoP, PurR, PutA, RcsB, Rob, SoxR, SoxS, TorR, YdeO
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
PutA Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External sensing using transported metabolites
Synonym(s): PoaA, PutC, fused DNA-binding transcriptional repressor / proline dehydrogenase / 1-pyrroline-5-carboxylate dehydrogenase PutA, proline utilization A
Gene name(s): putA
Functional conformation(s): PutA
Coregulator(s): BasR, MarA, PutA
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
BasR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): BasR response regulator, DNA-binding transcriptional dual regulator BasR, PmrA
Gene name(s): basR
Functional conformation(s): BasR-Phosphorylated
Coregulator(s): BasR, CRP, CpxR, Cra, CsgD, DksA, DksA-ppGpp, Fis, FliZ, H-NS, IHF, MarA, MlrA, MqsA, NagC, NanR, OmpR, PdhR, PhoP, PutA, QseB, RcdA, RcsB, RstA, SoxR, SoxS, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY BasR,MarA,PutA Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
BasR repressor MarA activator PutA repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
PutA repressor putAp putA 1078944 1078949 -21.5 gttgcacaaaGTTGCAacatcatgga [BPP]
[GEA]
[SM]
[1]
PutA repressor putAp putA 1078909 1078914 14.5 ataacgttaaGTTGCAcctttctgaa [BPP]
[GEA]
[SM]
[1]
PutA repressor putAp putA 1078954 1078959 -31.5 atttaacatgGTTGCAcaaagttgca [BPP]
[GEA]
[SM]
[2]
[3]
[1]
BasR-Phosphorylated repressor putAp putA 1078914 1078933 2.5 acatcatggaTATTTCACGATAACGTTAAGttgcaccttt [BPP]
[HIBSCS]
[4]
MarA activator putAp putA         [GEA] [5]

Evidence: [BPP] Binding of purified proteins
[GEA] Gene expression analysis
[SM] Site mutation
[HIBSCS] Human inference based on similarity to consensus sequences
Reference(s): [1] Zhou Y., et al., 2008
[2] Becker DF., et al., 2001
[3] Brown ED., et al., 1992
[4] Ogasawara H., et al., 2012
[5] Pomposiello PJ., et al., 2001



Reference(s)    

 [1] Zhou Y., Larson JD., Bottoms CA., Arturo EC., Henzl MT., Jenkins JL., Nix JC., Becker DF., Tanner JJ., 2008, Structural basis of the transcriptional regulation of the proline utilization regulon by multifunctional PutA., J Mol Biol 381(1):174-88

 [2] Becker DF., Thomas EA., 2001, Redox properties of the PutA protein from Escherichia coli and the influence of the flavin redox state on PutA-DNA interactions., Biochemistry 40(15):4714-21

 [3] Brown ED., Wood JM., 1992, Redesigned purification yields a fully functional PutA protein dimer from Escherichia coli., J Biol Chem 267(18):13086-92

 [4] Ogasawara H., Shinohara S., Yamamoto K., Ishihama A., 2012, Novel regulation targets of the metal-response BasS-BasR two-component system of Escherichia coli., Microbiology 158(Pt 6):1482-92

 [5] Pomposiello PJ., Bennik MH., Demple B., 2001, Genome-wide transcriptional profiling of the Escherichia coli responses to superoxide stress and sodium salicylate., J Bacteriol 183(13):3890-902


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