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ArcA,LldR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
ArcA Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class External-Two-component systems
Synonym(s): ArcA response regulator, CpxC, DNA-binding transcriptional dual regulator ArcA, Dye, FexA, Msp, Seg, SfrA, dye resistance protein
Gene name(s): arcA
Functional conformation(s): ArcA-Phosphorylated , ArcA
Coregulator(s): AdiY, AppY, ArcA, BetI, CRP, CadC, CaiF, Cra, CusR, CysB, DcuR, DksA-ppGpp, DnaA, DpiA, FNR, FadR, Fis, FlhDC, Fur, GadE, GadW, GadX, GatR, GlcC, GlpR, H-NS, HipB, HprR, HypT, IHF, IclR, IscR, LexA, LldR, Lrp, MarA, McbR, Mlc, ModE, MqsA, NarL, NarP, NsrR, NtrC, OmpR, PdhR, PhoP, PuuR, RcdA, RcsB, RhaS, Rob, RutR, SdiA, SlyA, SoxR, SoxS, TorR, TreR, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
LldR      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional dual regulator LldR, Lct, LctR
Gene name(s): lldR
Functional conformation(s): LldR-(S)-lactate , LldR
Coregulator(s): ArcA, LldR
Summary: TF Summary ...[more]

REGULATION EXERTED BY ArcA,LldR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
ArcA repressor LldR dual    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
LldR repressor lldPp lldP , lldR , lldD 3777307 3777329 30.0 ccctacacaaCACAATTGGCAGTGCCACTTTTAcacaacgtgt [AIBSCS]
[BPP]
[GEA]
[HIBSCS]
[SM]
[1]
[2]
ArcA-Phosphorylated repressor lldPp lldP , lldR , lldD 3777264 3777278 -18.0 gttgccaataCATAACATTTAGTTAaccattcatt [AIBSCS]
[BPP]
[GEA]
[HIBSCS]
[3]
[2]
[4]
ArcA-Phosphorylated repressor lldPp lldP , lldR , lldD 3777291 3777305 10.0 cattcattgtCATTATCCCTACACAacacaattgg [BPP]
[GEA]
[3]
[2]
[4]
LldR-(S)-lactate dual lldPp lldP , lldR , lldD 3777181 3777203 -97.0 ctccccccacAAGAATTGGCCCTACCAATTCTTcgcttatctg [AIBSCS]
[BPP]
[GEA]
[SM]
[1]
LldR dual lldPp lldP , lldR , lldD 3777181 3777203 -97.0 ctccccccacAAGAATTGGCCCTACCAATTCTTcgcttatctg [AIBSCS]
[BPP]
[GEA]
[SM]
[1]

Evidence: [AIBSCS] Automated inference based on similarity to consensus sequences
[BPP] Binding of purified proteins
[GEA] Gene expression analysis
[HIBSCS] Human inference based on similarity to consensus sequences
[SM] Site mutation
Reference(s): [1] Aguilera L., et al., 2008
[2] Lynch AS., et al., 1996
[3] Liu X., et al., 2004
[4] Mondragon V., et al., 2006



Reference(s)    

 [1] Aguilera L., Campos E., Gimenez R., Badia J., Aguilar J., Baldoma L., 2008, Dual role of LldR in regulation of the lldPRD operon, involved in L-lactate metabolism in Escherichia coli., J Bacteriol 190(8):2997-3005

 [2] Lynch AS., Lin EC., 1996, Transcriptional control mediated by the ArcA two-component response regulator protein of Escherichia coli: characterization of DNA binding at target promoters., J Bacteriol 178(21):6238-49

 [3] Liu X., De Wulf P., 2004, Probing the ArcA-P modulon of Escherichia coli by whole genome transcriptional analysis and sequence recognition profiling., J Biol Chem 279(13):12588-97

 [4] Mondragon V., Franco B., Jonas K., Suzuki K., Romeo T., Melefors O., Georgellis D., 2006, pH-dependent activation of the BarA-UvrY two-component system in Escherichia coli., J Bacteriol 188(23):8303-6


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