RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


H-NS,IHF,Lrp regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
H-NS      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): BglY, Cur, DNA-binding protein HLP-II (HU, BH2, HD, NS), DNA-binding transcriptional dual regulator H-NS, Drc, DrdX, Drs, FimG, Hns, HnsA, Irk, MsyA, OsmZ, PilG, TopS, TopX, VirR
Gene name(s): hns
Functional conformation(s): H-NS
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, BasR, CRP, CadC, CaiF, CdaR, CpxR, Cra, CsgD, CspA, CysB, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, FNR, Fis, FlhDC, FliZ, Fur, GadE, GadW, GadX, GalR, GalS, GlaR, GutM, H-NS, HU, HdfR, HypT, IHF, LacI, LeuO, LrhA, Lrp, MarA, MatA, McbR, MlrA, MntR, MqsA, NagC, NanR, NarL, NarP, NhaR, NrdR, NsrR, OmpR, OxyR, PhoB, PhoP, QseB, RcdA, RcsB, Rob, RstA, RutR, SdiA, SlyA, SoxS, SrlR, StpA, SutR, TorR, UvrY, YdeO, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
Lrp Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Sensing external and internal signals
Synonym(s): AlsB, DNA-binding transcriptional dual regulator Lrp, Ihb, LivR, Lrs, Lss, LstR, Mbf, OppI, RblA
Gene name(s): lrp
Functional conformation(s): Lrp , Lrp-leucine
Coregulator(s): AcrR, Ada, AdiY, AidB, ArcA, ArgP, ArgR, CRP, CadC, CpxR, Cra, DksA, DksA-ppGpp, EnvY, FNR, Fis, FliZ, Fur, GadE, GadW, GadX, GcvA, GlaR, H-NS, HU, HdfR, IHF, LrhA, Lrp, MarA, Mlc, ModE, Nac, NarL, NhaR, NsrR, OmpR, PhoP, PurR, RcsB, Rob, SoxS, StpA, TorR, YeiL, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
IHF Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): DNA-binding transcriptional dual regulator IHF
Gene name(s): ihfB, ihfA
Functional conformation(s): IHF
Coregulator(s): AcrR, AdiY, ArcA, ArgR, AtoC, BasR, CRP, Cbl, CpxR, Cra, CsgD, CysB, DksA, DksA-ppGpp, EnvY, FNR, FadR, FhlA, Fis, FlhDC, FliZ, Fur, GadE, GlcC, GlpR, GlrR, H-NS, HU, HdfR, HipB, IHF, IclR, IscR, LrhA, Lrp, MarA, MatA, MlrA, MntR, ModE, MprA, MqsA, Nac, NagC, NanR, NarL, NarP, NorR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PepA, PhoB, PspF, PurR, QseB, RcdA, RcsB, Rob, RstA, RtcR, RutR, SlyA, SoxR, SoxS, SutR, TdcA, TdcR, TrpR, TyrR, UlaR, UvrY, YeiL, YiaJ, YjjQ, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY H-NS,IHF,Lrp Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
H-NS activator IHF activator Lrp activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
IHF activator fimAp fimA , fimI , fimC , fimD , fimF , fimG , fimH 4542764 4542776 77.0 aaaaagcatcTAACTGTTTGATAtgtaaattat [GEA]
[HIBSCS]
[1]
[2]
[3]
[4]
Lrp activator fimAp fimA , fimI , fimC , fimD , fimF , fimG , fimH 4542859 4542873 173.0 gacgcatcttCCTCATTCTTCTCTCcaaaaaccac [BPP]
[SM]
[5]
Lrp activator fimAp fimA , fimI , fimC , fimD , fimF , fimG , fimH 4542921 4542935 235.0 aagataacaaTAGAATATTAAGCCAacaaataaac [BPP]
[HIBSCS]
[SM]
[6]
[5]
Lrp activator fimAp fimA , fimI , fimC , fimD , fimF , fimG , fimH 4542890 4542904 204.0 ccacctcatgCAATATAAACATCTAtaaataaaga [BPP]
[HIBSCS]
[SM]
[6]
[5]
IHF activator fimAp fimA , fimI , fimC , fimD , fimF , fimG , fimH 4542636 4542648 -52.0 aggtttgattTAACTTATTGATAataaagttaa [GEA]
[HIBSCS]
[1]
[2]
[3]
[4]
H-NS activator fimAp fimA , fimI , fimC , fimD , fimF , fimG , fimH         [BPP]
[GEA]
[7]

Evidence: [GEA] Gene expression analysis
[HIBSCS] Human inference based on similarity to consensus sequences
[BPP] Binding of purified proteins
[SM] Site mutation
Reference(s): [1] Blomfield IC., et al., 1997
[2] Dorman CJ., et al., 1987
[3] Dove SL., et al., 1996
[4] Kulasekara HD., et al., 1999
[5] Roesch PL., et al., 1998
[6] Gally DL., et al., 1994
[7] Schembri MA., et al., 1998



Reference(s)    

 [1] Blomfield IC., Kulasekara DH., Eisenstein BI., 1997, Integration host factor stimulates both FimB- and FimE-mediated site-specific DNA inversion that controls phase variation of type 1 fimbriae expression in Escherichia coli., Mol Microbiol 23(4):705-17

 [2] Dorman CJ., Higgins CF., 1987, Fimbrial phase variation in Escherichia coli: dependence on integration host factor and homologies with other site-specific recombinases., J Bacteriol 169(8):3840-3

 [3] Dove SL., Dorman CJ., 1996, Multicopy fimB gene expression in Escherichia coli: binding to inverted repeats in vivo, effect on fimA gene transcription and DNA inversion., Mol Microbiol 21(6):1161-73

 [4] Kulasekara HD., Blomfield IC., 1999, The molecular basis for the specificity of fimE in the phase variation of type 1 fimbriae of Escherichia coli K-12., Mol Microbiol 31(4):1171-81

 [5] Roesch PL., Blomfield IC., 1998, Leucine alters the interaction of the leucine-responsive regulatory protein (Lrp) with the fim switch to stimulate site-specific recombination in Escherichia coli., Mol Microbiol 27(4):751-61

 [6] Gally DL., Rucker TJ., Blomfield IC., 1994, The leucine-responsive regulatory protein binds to the fim switch to control phase variation of type 1 fimbrial expression in Escherichia coli K-12., J Bacteriol 176(18):5665-72

 [7] Schembri MA., Olsen PB., Klemm P., 1998, Orientation-dependent enhancement by H-NS of the activity of the type 1 fimbrial phase switch promoter in Escherichia coli., Mol Gen Genet 259(3):336-44


RegulonDB