RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


CRP,FNR,Fis,H-NS,SlyA regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
Fis Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): DNA-binding transcriptional dual regulator Fis, Nbp, site-specific DNA inversion stimulation factor
Gene name(s): fis
Functional conformation(s): Fis
Coregulator(s): AcrR, AdiY, AppY, ArcA, ArgP, BasR, CRP, CpxR, Cra, CreB, CspA, CusR, CytR, DeoR, DksA, DksA-ppGpp, DnaA, FNR, FadR, Fis, FlhDC, FliZ, Fur, GadE, GadW, GadX, GlcC, GlpR, H-NS, HprR, IHF, IscR, LeuO, Lrp, MalT, MarA, MarR, MazE, Mlc, MntR, ModE, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PepA, PurR, RcsB, Rob, RstA, RutR, SlyA, SoxS, StpA, TorR, XylR, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
FNR Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator FNR, NirA, NirR, OssA, OxrA
Gene name(s): fnr
Functional conformation(s): FNR , FNR-[2Fe-2S]2+ oxidized
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, CRP, CadC, CaiF, Cbl, CdaR, Cra, CueR, CusR, CysB, DcuR, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, ExuR, FNR, FhlA, Fis, FlhDC, Fur, GadE, GadW, GadX, GcvA, GlpR, H-NS, HdfR, HprR, HyfR, HypT, IHF, LeuO, Lrp, MalT, MarA, MetR, MlrA, ModE, Nac, NagC, NarL, NarP, NfeR, NikR, NorR, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PhoB, PhoP, PurR, PuuR, RcsB, Rob, RstA, RutR, SlyA, SoxR, SoxS, TdcA, TdcR, TorR, YeiL, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP-cAMP , CRP
Coregulator(s): AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BtsR, CRP, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FucR, Fur, GadE, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsB, RhaR, RhaS, Rob, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YiaJ, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
H-NS      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): BglY, Cur, DNA-binding protein HLP-II (HU, BH2, HD, NS), DNA-binding transcriptional dual regulator H-NS, Drc, DrdX, Drs, FimG, Hns, HnsA, Irk, MsyA, OsmZ, PilG, TopS, TopX, VirR
Gene name(s): hns
Functional conformation(s): H-NS
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, BasR, CRP, CadC, CaiF, CdaR, CpxR, Cra, CsgD, CspA, CysB, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, FNR, Fis, FlhDC, FliZ, Fur, GadE, GadW, GadX, GalR, GalS, GlaR, GutM, H-NS, HU, HdfR, HypT, IHF, LacI, LeuO, LrhA, Lrp, MarA, MatA, McbR, MlrA, MntR, MqsA, NagC, NanR, NarL, NarP, NhaR, NrdR, NsrR, OmpR, OxyR, PhoB, PhoP, QseB, RcdA, RcsB, Rob, RstA, RutR, SdiA, SlyA, SoxS, SrlR, StpA, SutR, TorR, UvrY, YdeO, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
SlyA Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator SlyA
Gene name(s): slyA
Functional conformation(s): SlyA
Coregulator(s): ArcA, CRP, FNR, Fis, Fur, H-NS, IHF, LeuO, LrhA, McbR, PaaX, PhoP, RcdA, SdiA, SlyA, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY CRP,FNR,Fis,H-NS,SlyA Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CRP activator FNR activator Fis repressor H-NS dual SlyA activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
H-NS dual hlyEp hlyE 1230465 1230479 -6.0 gcccggctaaCTATGAATTAGATGAagtaaaattt [BPP]
[GEA]
[1]
[2]
[3]
H-NS dual hlyEp hlyE 1230515 1230529 -56.5 attgtttgatATTTATCATATTAATagaaataaag [BPP]
[GEA]
[1]
[2]
[3]
SlyA activator hlyEp hlyE 1230516 1230527 -55.5 tgtttgatatTTATCATATTAAtagaaataaa [BPP]
[GEA]
[1]
[4]
[3]
CRP-cAMP activator hlyEp hlyE 1230517 1230538 -61.5 acattaaacaTTGTTTGATATTTATCATATTAatagaaataa [BPP]
[GEA]
[SM]
[2]
[3]
SlyA activator hlyEp hlyE 1230505 1230516 -44.5 tatcatattaATAGAAATAAAGacattgacgc [BPP]
[GEA]
[1]
[4]
[5]
[2]
[3]
SlyA activator hlyEp hlyE 1230409 1230420 52.5 tcattacaatTTATATATTTAAagaggcgaat [BPP]
[GEA]
[1]
SlyA activator hlyEp hlyE 1230400 1230411 61.5 tttatatattTAAAGAGGCGAAtgattatgac [BPP]
[GEA]
[1]
SlyA activator hlyEp hlyE 1230385 1230396 76.5 aggcgaatgaTTATGACTGAAAtcgttgcaga [BPP]
[GEA]
[1]
SlyA activator hlyEp hlyE 1230371 1230382 90.5 gactgaaatcGTTGCAGATAAAacggtagaag [BPP]
[GEA]
[1]
Fis repressor hlyEp hlyE 1230651 1230665 -192.0 tgcataggctGCTGATTTTTCGTTCtcttatcttg [AIBSCS]
[GEA]
[6]
Fis repressor hlyEp hlyE 1230569 1230583 -110.0 aatatcacccGGCTAAAAAATAGAAtagaagcatt [AIBSCS]
[GEA]
[6]
Fis repressor hlyEp hlyE 1230522 1230536 -63.0 attaaacattGTTTGATATTTATCAtattaataga [AIBSCS]
[GEA]
[6]
Fis repressor hlyEp hlyE 1230451 1230465 9.0 gaattagatgAAGTAAAATTTATTAatagttgtaa [AIBSCS]
[GEA]
[6]
Fis repressor hlyEp hlyE 1230441 1230455 19.0 aagtaaaattTATTAATAGTTGTAAaacaggagtt [AIBSCS]
[GEA]
[6]
FNR activator hlyEp hlyE 1230521 1230534 -61.5 taaacattgtTTGATATTTATCATattaatagaa [BPP]
[GEA]
[2]
[3]
H-NS dual hlyEp hlyE 1230465 1230479 -6.0 gcccggctaaCTATGAATTAGATGAagtaaaattt [BPP]
[GEA]
[1]
[2]
[3]
H-NS dual hlyEp hlyE 1230515 1230529 -56.5 attgtttgatATTTATCATATTAATagaaataaag [BPP]
[GEA]
[1]
[2]
[3]

Evidence: [BPP] Binding of purified proteins
[GEA] Gene expression analysis
[SM] Site mutation
[AIBSCS] Automated inference based on similarity to consensus sequences
Reference(s): [1] Lithgow JK., et al., 2007
[2] Westermark M., et al., 2000
[3] Wyborn NR., et al., 2004
[4] Ludwig A., et al., 1999
[5] Oscarsson J., et al., 1996
[6] Bradley MD., et al., 2007



Reference(s)    

 [1] Lithgow JK., Haider F., Roberts IS., Green J., 2007, Alternate SlyA and H-NS nucleoprotein complexes control hlyE expression in Escherichia coli K-12., Mol Microbiol 66(3):685-98

 [2] Westermark M., Oscarsson J., Mizunoe Y., Urbonaviciene J., Uhlin BE., 2000, Silencing and activation of ClyA cytotoxin expression in Escherichia coli., J Bacteriol 182(22):6347-57

 [3] Wyborn NR., Stapleton MR., Norte VA., Roberts RE., Grafton J., Green J., 2004, Regulation of Escherichia coli hemolysin E expression by H-NS and Salmonella SlyA., J Bacteriol 186(6):1620-8

 [4] Ludwig A., Bauer S., Benz R., Bergmann B., Goebel W., 1999, Analysis of the SlyA-controlled expression, subcellular localization and pore-forming activity of a 34 kDa haemolysin (ClyA) from Escherichia coli K-12., Mol Microbiol 31(2):557-67

 [5] Oscarsson J., Mizunoe Y., Uhlin BE., Haydon DJ., 1996, Induction of haemolytic activity in Escherichia coli by the slyA gene product., Mol Microbiol 20(1):191-9

 [6] Bradley MD., Beach MB., de Koning AP., Pratt TS., Osuna R., 2007, Effects of Fis on Escherichia coli gene expression during different growth stages., Microbiology 153(Pt 9):2922-40


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