RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


CRP,FNR,FhlA,HyfR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
FNR Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator FNR, NirA, NirR, OssA, OxrA
Gene name(s): fnr
Functional conformation(s): FNR , FNR-[2Fe-2S]2+ oxidized
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, CRP, CadC, CaiF, Cbl, CdaR, Cra, CueR, CusR, CysB, DcuR, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, ExuR, FNR, FhlA, Fis, FlhDC, Fur, GadE, GadW, GadX, GcvA, GlpR, H-NS, HdfR, HprR, HyfR, HypT, IHF, LeuO, Lrp, MalT, MarA, MetR, MlrA, ModE, Nac, NagC, NarL, NarP, NfeR, NikR, NorR, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PhoB, PhoP, PurR, PuuR, RcsB, Rob, RstA, RutR, SlyA, SoxR, SoxS, TdcA, TdcR, TorR, YeiL, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP-cAMP , CRP
Coregulator(s): AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BtsR, CRP, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FucR, Fur, GadE, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsB, RhaR, RhaS, Rob, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YiaJ, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
HyfR      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional activator HyfR
Gene name(s): hyfR
Functional conformation(s): HyfR
Coregulator(s): CRP, FNR, FhlA, HyfR
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
FhlA Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional activator FhlA, Fhl, formate hydrogen-lyase transcriptional activator for fdhF, hyc and hyp operons
Gene name(s): fhlA
Functional conformation(s): FhlA-formate , FhlA
Coregulator(s): CRP, FNR, FhlA, FlhDC, HyfR, IHF, ModE, NarL, NarP, NsrR
Summary: TF Summary ...[more]

REGULATION EXERTED BY CRP,FNR,FhlA,HyfR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CRP activator FNR repressor FhlA activator HyfR activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CRP-cAMP activator hyfAp hyfA , hyfB , hyfC , hyfD , hyfE , hyfF , hyfG , hyfH , hyfI , hyfJ , hyfR , focB 2601000 2601022 -160.5 atacctcactTCTCGTGATCAAGATCACATTCTcgctttcccc [AIBSCS]
[GEA]
[HIBSCS]
[1]
[2]
FhlA-formate activator hyfAp hyfA , hyfB , hyfC , hyfD , hyfE , hyfF , hyfG , hyfH , hyfI , hyfJ , hyfR , focB 2601034 2601047 -130.0 gctttcccctGCGACACGGGTGTCgaatccattt [GEA] [1]
[3]
HyfR activator hyfAp hyfA , hyfB , hyfC , hyfD , hyfE , hyfF , hyfG , hyfH , hyfI , hyfJ , hyfR , focB 2601033 2601050 -129.5 cgctttccccTGCGACACGGGTGTCGAAtccatttttt [AIBSCS]
[GEA]
[1]
[3]
FNR repressor hyfAp hyfA , hyfB , hyfC , hyfD , hyfE , hyfF , hyfG , hyfH , hyfI , hyfJ , hyfR , focB 2601059 2601072 -105.5 aatccattttTTGCTGAACGTTAAtgaccatcat [GEA]
[HIBSCS]
[1]

Evidence: [AIBSCS] Automated inference based on similarity to consensus sequences
[GEA] Gene expression analysis
[HIBSCS] Human inference based on similarity to consensus sequences
Reference(s): [1] Self WT., et al., 2004
[2] Tsai MJ., et al., 2018
[3] Skibinski DA., et al., 2002



Reference(s)    

 [1] Self WT., Hasona A., Shanmugam KT., 2004, Expression and regulation of a silent operon, hyf, coding for hydrogenase 4 isoenzyme in Escherichia coli., J Bacteriol 186(2):580-7

 [2] Tsai MJ., Wang JR., Yang CD., Kao KC., Huang WL., Huang HY., Tseng CP., Huang HD., Ho SY., 2018, PredCRP: predicting and analysing the regulatory roles of CRP from its binding sites in Escherichia coli., Sci Rep 8(1):951

 [3] Skibinski DA., Golby P., Chang YS., Sargent F., Hoffman R., Harper R., Guest JR., Attwood MM., Berks BC., Andrews SC., 2002, Regulation of the hydrogenase-4 operon of Escherichia coli by the sigma(54)-dependent transcriptional activators FhlA and HyfR., J Bacteriol 184(23):6642-53


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