RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


CRP,FNR,Fis,GlpR,IHF regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
Fis Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): DNA-binding transcriptional dual regulator Fis, Nbp, site-specific DNA inversion stimulation factor
Gene name(s): fis
Functional conformation(s): Fis
Coregulator(s): AcrR, AdiY, AppY, ArcA, ArgP, BasR, CRP, CpxR, Cra, CreB, CspA, CusR, CytR, DeoR, DksA, DksA-ppGpp, DnaA, FNR, FadR, Fis, FlhDC, FliZ, Fur, GadE, GadW, GadX, GlcC, GlpR, H-NS, HprR, IHF, IscR, LeuO, Lrp, MalT, MarA, MarR, MazE, Mlc, MntR, ModE, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PepA, PurR, RcsB, Rob, RstA, RutR, SlyA, SoxS, StpA, TorR, XylR, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
FNR Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator FNR, NirA, NirR, OssA, OxrA
Gene name(s): fnr
Functional conformation(s): FNR , FNR-[2Fe-2S]2+ oxidized
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, CRP, CadC, CaiF, Cbl, CdaR, Cra, CueR, CusR, CysB, DcuR, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, ExuR, FNR, FhlA, Fis, FlhDC, Fur, GadE, GadW, GadX, GcvA, GlpR, H-NS, HdfR, HprR, HyfR, HypT, IHF, LeuO, Lrp, MalT, MarA, MetR, MlrA, ModE, Nac, NagC, NarL, NarP, NfeR, NikR, NorR, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PhoB, PhoP, PurR, PuuR, RcsB, Rob, RstA, RutR, SlyA, SoxR, SoxS, TdcA, TdcR, TorR, YeiL, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP-cAMP , CRP
Coregulator(s): AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BtsR, CRP, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FucR, Fur, GadE, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsB, RhaR, RhaS, Rob, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YiaJ, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
GlpR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Gene name(s): glpR
Functional conformation(s): GlpR-sn-glycerol 3-phosphate , GlpR-glycerol , GlpR
Coregulator(s): ArcA, CRP, FNR, Fis, FlhDC, GlpR, IHF
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
IHF Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): DNA-binding transcriptional dual regulator IHF
Gene name(s): ihfB, ihfA
Functional conformation(s): IHF
Coregulator(s): AcrR, AdiY, ArcA, ArgR, AtoC, BasR, CRP, Cbl, CpxR, Cra, CsgD, CysB, DksA, DksA-ppGpp, EnvY, FNR, FadR, FhlA, Fis, FlhDC, FliZ, Fur, GadE, GlcC, GlpR, GlrR, H-NS, HU, HdfR, HipB, IHF, IclR, IscR, LrhA, Lrp, MarA, MatA, MlrA, MntR, ModE, MprA, MqsA, Nac, NagC, NanR, NarL, NarP, NorR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PepA, PhoB, PspF, PurR, QseB, RcdA, RcsB, Rob, RstA, RtcR, RutR, SlyA, SoxR, SoxS, SutR, TdcA, TdcR, TrpR, TyrR, UlaR, UvrY, YeiL, YiaJ, YjjQ, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY CRP,FNR,Fis,GlpR,IHF Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CRP activator FNR activator Fis activator GlpR repressor IHF repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CRP-cAMP activator glpTQp glpQ , glpT 2352532 2352553 -91.5 ttcgaaagtgAAACGTGATTTCATGCGTCATTttgaacattt [BPP]
[GEA]
[HIBSCS]
[1]
[2]
[3]
CRP-cAMP activator glpTQp glpQ , glpT 2352482 2352503 -41.5 ttatttaataATGTGTGCGGCAATTCACATTTaatttatgaa [AIBSCS]
[BPP]
[GEA]
[HIBSCS]
[1]
[2]
[3]
[4]
CRP-cAMP activator glpTQp glpQ , glpT 2352572 2352593 -131.5 aaaacatgaaTTGTTTGATTTCGCGCATATTCgctcataatt [BPP]
[GEA]
[HIBSCS]
[1]
[2]
[3]
GlpR repressor glpTQp glpQ , glpT 2352483 2352502 -41.5 tatttaataaTGTGTGCGGCAATTCACATTtaatttatga [BPP]
[HIBSCS]
[SM]
[1]
[5]
IHF repressor glpTQp glpQ , glpT 2352244 2352256 202.0 ggctatgcggCTTACTATTTGGTtcgtaagaac [BPP]
[GEA]
[HIBSCS]
[3]
IHF repressor glpTQp glpQ , glpT 2352411 2352423 35.0 ttctctcactGAATCAGGCTGTTaatcataaat [BPP]
[GEA]
[HIBSCS]
[3]
GlpR repressor glpTQp glpQ , glpT 2352094 2352113 348.5 ttcggtatcgGATCGCTCGAATCCGCGCGTtttcctgccc [BPP]
[GEA]
[SM]
[3]
GlpR repressor glpTQp glpQ , glpT 2352109 2352128 333.5 gaaattcatcATGGGTTCGGTATCGGATCGctcgaatccg [BPP]
[GEA]
[SM]
[3]
GlpR repressor glpTQp glpQ , glpT 2352127 2352146 315.5 gattgcttatGGATTTTCGAAATTCATCATgggttcggta [BPP]
[GEA]
[SM]
[3]
GlpR repressor glpTQp glpQ , glpT 2352614 2352633 -172.5 tatccctctgAAGTTCGTTTTTTACCATTTagccatagta [BPP]
[HIBSCS]
[SM]
[1]
[3]
[5]
GlpR repressor glpTQp glpQ , glpT 2352574 2352593 -132.5 aaaacatgaaTTGTTTGATTTCGCGCATATtcgctcataa [BPP]
[HIBSCS]
[SM]
[1]
[3]
[5]
GlpR repressor glpTQp glpQ , glpT 2352555 2352574 -113.5 ttcgcgcataTTCGCTCATAATTCGAAAGTgaaacgtgat [BPP]
[HIBSCS]
[SM]
[1]
[3]
[5]
GlpR repressor glpTQp glpQ , glpT 2352523 2352542 -81.5 aacgtgatttCATGCGTCATTTTGAACATTttgtaaatct [BPP]
[HIBSCS]
[SM]
[1]
[3]
[5]
Fis activator glpTQp glpQ , glpT 2352610 2352624 -166.0 gaagttcgttTTTTACCATTTAGCCatagtaaaaa [AIBSCS]
[GEA]
[6]
Fis activator glpTQp glpQ , glpT 2352557 2352571 -113.0 gcgcatattcGCTCATAATTCGAAAgtgaaacgtg [AIBSCS]
[GEA]
[6]
Fis activator glpTQp glpQ , glpT 2352515 2352529 -71.0 gcgtcattttGAACATTTTGTAAATcttatttaat [AIBSCS]
[GEA]
[6]
Fis activator glpTQp glpQ , glpT 2352508 2352522 -64.0 tttgaacattTTGTAAATCTTATTTaataatgtgt [AIBSCS]
[GEA]
[6]
Fis activator glpTQp glpQ , glpT 2352460 2352474 -16.0 tttaatttatGAATGTTTTCTTAACatcgcggcaa [AIBSCS]
[GEA]
[6]
Fis activator glpTQp glpQ , glpT 2352396 2352410 49.0 tcaggctgttAATCATAAATAAGACcacgggccac [AIBSCS]
[GEA]
[6]
FNR activator glpTQp glpQ , glpT 2352576 2352589 -131.5 catgaattgtTTGATTTCGCGCATattcgctcat [GEA]
[HIBSCS]
[7]
[8]
[3]
FNR activator glpTQp glpQ , glpT 2352536 2352549 -91.5 aaagtgaaacGTGATTTCATGCGTcattttgaac [AIBSCS]
[GEA]
[7]
[8]
[3]

Evidence: [BPP] Binding of purified proteins
[GEA] Gene expression analysis
[HIBSCS] Human inference based on similarity to consensus sequences
[AIBSCS] Automated inference based on similarity to consensus sequences
[SM] Site mutation
Reference(s): [1] Larson TJ., et al., 1992
[2] Weissenborn DL., et al., 1992
[3] Yang B., et al., 1997
[4] Zheng D., et al., 2004
[5] Zhao N., et al., 1994
[6] Bradley MD., et al., 2007
[7] Kuritzkes DR., et al., 1984
[8] Wong KK., et al., 1992



Reference(s)    

 [1] Larson TJ., Cantwell JS., van Loo-Bhattacharya AT., 1992, Interaction at a distance between multiple operators controls the adjacent, divergently transcribed glpTQ-glpACB operons of Escherichia coli K-12., J Biol Chem 267(9):6114-21

 [2] Weissenborn DL., Wittekindt N., Larson TJ., 1992, Structure and regulation of the glpFK operon encoding glycerol diffusion facilitator and glycerol kinase of Escherichia coli K-12., J Biol Chem 267(9):6122-31

 [3] Yang B., Gerhardt SG., Larson TJ., 1997, Action at a distance for glp repressor control of glpTQ transcription in Escherichia coli K-12., Mol Microbiol 24(3):511-21

 [4] Zheng D., Constantinidou C., Hobman JL., Minchin SD., 2004, Identification of the CRP regulon using in vitro and in vivo transcriptional profiling., Nucleic Acids Res 32(19):5874-93

 [5] Zhao N., Oh W., Trybul D., Thrasher KS., Kingsbury TJ., Larson TJ., 1994, Characterization of the interaction of the glp repressor of Escherichia coli K-12 with single and tandem glp operator variants., J Bacteriol 176(8):2393-7

 [6] Bradley MD., Beach MB., de Koning AP., Pratt TS., Osuna R., 2007, Effects of Fis on Escherichia coli gene expression during different growth stages., Microbiology 153(Pt 9):2922-40

 [7] Kuritzkes DR., Zhang XY., Lin EC., 1984, Use of phi(glp-lac) in studies of respiratory regulation of the Escherichia coli anaerobic sn-glycerol-3-phosphate dehydrogenase genes (glpAB)., J Bacteriol 157(2):591-8

 [8] Wong KK., Kwan HS., 1992, Transcription of glpT of Escherichia coli K12 is regulated by anaerobiosis and fnr., FEMS Microbiol Lett 73(1-2):15-8


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