RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


CRP,GalR,GalS,NagC regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP-cAMP , CRP
Coregulator(s): AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BtsR, CRP, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FucR, Fur, GadE, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsB, RhaR, RhaS, Rob, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YiaJ, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
NagC Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External sensing using transported metabolites
Synonym(s): DNA-binding transcriptional dual regulator NagC, NagR, transcriptional repressor of nag (N-acetylglucosamine) operon
Gene name(s): nagC
Functional conformation(s): NagC , NagC-N-acetyl-D-glucosamine 6-phosphate
Coregulator(s): AraC, BasR, CRP, ChbR, Cra, DksA, DksA-ppGpp, EvgA, FNR, Fur, GadX, GalR, GalS, H-NS, IHF, LexA, Mlc, NagC, NanR, NarL, NarP, PhoP, RcsB, UvrY, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
GalS Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional dual regulator GalS, MglD
Gene name(s): galS
Functional conformation(s): GalS-D-galactose , GalS
Coregulator(s): CRP, FlhDC, GalR, GalS, H-NS, HU, NagC
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
GalR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional dual regulator GalR
Gene name(s): galR
Functional conformation(s): GalR , GalR-D-galactose
Coregulator(s): CRP, FlhDC, GalR, GalS, H-NS, HU, NagC
Summary: TF Summary ...[more]

REGULATION EXERTED BY CRP,GalR,GalS,NagC Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CRP activator GalR repressor GalS repressor NagC repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CRP-cAMP activator galPp galP 3088202 3088224 -42.5 gcgattacacTGATGTGATTTGCTTCACATCTTtttacgtcgt [AIBSCS]
[GEA]
[HIBSCS]
[1]
[2]
[3]
GalS repressor galPp galP 3088383 3088398 136.5 cctggatatcGGTGTAATTGCTGGCGcactgccgtt [BPP]
[GEA]
[SM]
[4]
[5]
[1]
[3]
GalS repressor galPp galP 3088186 3088201 -61.5 ataaatgttaGTGTAAGCGATTACACtgatgtgatt [BPP]
[GEA]
[SM]
[4]
[5]
[1]
[3]
GalR-D-galactose repressor galPp galP 3088004 3088019 -243.5 atcatcacaaCTGAAACCGATTACACcaaccacaac [AIBSCS]
[BPP]
[SM]
[4]
GalR-D-galactose repressor galPp galP 3088069 3088084 -178.5 ttattcggttTTCACAGTTGTTACATttcttttcag [AIBSCS]
[BPP]
[SM]
[4]
GalR-D-galactose repressor galPp galP 3088040 3088055 -207.5 agacaaagatTTGTAATATTTTCATAttattattcg [BPP] [4]
GalR-D-galactose repressor galPp galP 3088140 3088155 -107.5 tgatgatataACTCAATTATTTTCATgcacttaaat [AIBSCS]
[BPP]
[SM]
[4]
NagC repressor galPp galP 3088245 3088267 2.0 actcacctatCTTAATTCACAATAAAAAATAACcatattggag [AIBSCS]
[BPP]
[SM]
[4]
[6]
GalS-D-galactose repressor galPp galP 3088004 3088019 -243.5 atcatcacaaCTGAAACCGATTACACcaaccacaac [AIBSCS]
[BPP]
[SM]
[4]
GalS-D-galactose repressor galPp galP 3088140 3088155 -107.5 tgatgatataACTCAATTATTTTCATgcacttaaat [AIBSCS]
[BPP]
[SM]
[4]
GalS-D-galactose repressor galPp galP 3088069 3088084 -178.5 ttattcggttTTCACAGTTGTTACATttcttttcag [AIBSCS]
[BPP]
[SM]
[4]
GalR repressor galPp galP 3088186 3088201 -61.5 ataaatgttaGTGTAAGCGATTACACtgatgtgatt [BPP]
[GEA]
[HIBSCS]
[SM]
[4]
[5]
[1]
[3]
GalR repressor galPp galP 3088383 3088398 136.5 cctggatatcGGTGTAATTGCTGGCGcactgccgtt [BPP]
[GEA]
[HIBSCS]
[SM]
[4]
[5]
[1]
[3]
GalS-D-galactose repressor galPp galP 3088040 3088055 -207.5 agacaaagatTTGTAATATTTTCATAttattattcg [AIBSCS]
[BPP]
[4]

Evidence: [AIBSCS] Automated inference based on similarity to consensus sequences
[GEA] Gene expression analysis
[HIBSCS] Human inference based on similarity to consensus sequences
[BPP] Binding of purified proteins
[SM] Site mutation
Reference(s): [1] Semsey S., et al., 2007
[2] Tsai MJ., et al., 2018
[3] Weickert MJ., et al., 1993
[4] El Qaidi S., et al., 2008
[5] Geanacopoulos M., et al., 1997
[6] Oberto J. 2010



Reference(s)    

 [1] Semsey S., Krishna S., Sneppen K., Adhya S., 2007, Signal integration in the galactose network of Escherichia coli., Mol Microbiol 65(2):465-76

 [2] Tsai MJ., Wang JR., Yang CD., Kao KC., Huang WL., Huang HY., Tseng CP., Huang HD., Ho SY., 2018, PredCRP: predicting and analysing the regulatory roles of CRP from its binding sites in Escherichia coli., Sci Rep 8(1):951

 [3] Weickert MJ., Adhya S., 1993, The galactose regulon of Escherichia coli., Mol Microbiol 10(2):245-51

 [4] El Qaidi S., Allemand F., Oberto J., Plumbridge J., 2008, Repression of galP, the galactose transporter in Escherichia coli, requires the specific regulator of N-acetylglucosamine metabolism., Mol Microbiol

 [5] Geanacopoulos M., Adhya S., 1997, Functional characterization of roles of GalR and GalS as regulators of the gal regulon., J Bacteriol 179(1):228-34

 [6] Oberto J., 2010, FITBAR: a web tool for the robust prediction of prokaryotic regulons., BMC Bioinformatics 11:554


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