RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


EvgA,H-NS regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
H-NS      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): BglY, Cur, DNA-binding protein HLP-II (HU, BH2, HD, NS), DNA-binding transcriptional dual regulator H-NS, Drc, DrdX, Drs, FimG, Hns, HnsA, Irk, MsyA, OsmZ, PilG, TopS, TopX, VirR
Gene name(s): hns
Functional conformation(s): H-NS
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, BasR, CRP, CadC, CaiF, CdaR, CpxR, Cra, CsgD, CspA, CysB, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, FNR, Fis, FlhDC, FliZ, Fur, GadE, GadW, GadX, GalR, GalS, GlaR, GutM, H-NS, HU, HdfR, HypT, IHF, LacI, LeuO, LrhA, Lrp, MarA, MatA, McbR, MlrA, MntR, MqsA, NagC, NanR, NarL, NarP, NhaR, NrdR, NsrR, OmpR, OxyR, PhoB, PhoP, QseB, RcdA, RcsB, Rob, RstA, RutR, SdiA, SlyA, SoxS, SrlR, StpA, SutR, TorR, UvrY, YdeO, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
EvgA Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional activator EvgA, EvgA response regulator
Gene name(s): evgA
Functional conformation(s): EvgA-Phosphorylated , EvgA
Coregulator(s): CRP, EvgA, FNR, FliZ, GadE, GadW, GadX, H-NS, NagC, NarL, NarP, PhoP, RcsB, UvrY, YdeO
Summary: TF Summary ...[more]

REGULATION EXERTED BY EvgA,H-NS Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
EvgA activator H-NS repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
EvgA-Phosphorylated activator evgAp2 evgA , evgS 2483513 2483530 -109.5 tgcaatacaaTTCTTACGCCTGTAGGATtagtaagaag [AIBSCS]
[BPP]
[GEA]
[HIBSCS]
[1]
[2]
[3]
EvgA-Phosphorylated activator evgAp1 evgA , evgS 2483513 2483530 -119.5 tgcaatacaaTTCTTACGCCTGTAGGATtagtaagaag [AIBSCS]
[BPP]
[GEA]
[HIBSCS]
[1]
[2]
[3]
H-NS repressor evgAp2 evgA , evgS         [BPP] [4]
H-NS repressor evgAp1 evgA , evgS         [BPP] [4]

Evidence: [AIBSCS] Automated inference based on similarity to consensus sequences
[BPP] Binding of purified proteins
[GEA] Gene expression analysis
[HIBSCS] Human inference based on similarity to consensus sequences
Reference(s): [1] Eguchi Y., et al., 2003
[2] Masuda N., et al., 2003
[3] Tanabe H., et al., 1998
[4] Krin E., et al., 2010



Reference(s)    

 [1] Eguchi Y., Oshima T., Mori H., Aono R., Yamamoto K., Ishihama A., Utsumi R., 2003, Transcriptional regulation of drug efflux genes by EvgAS, a two-component system in Escherichia coli., Microbiology 149(Pt 10):2819-28

 [2] Masuda N., Church GM., 2003, Regulatory network of acid resistance genes in Escherichia coli., Mol Microbiol 48(3):699-712

 [3] Tanabe H., Yamasaki K., Katoh A., Yoshioka S., Utsumi R., 1998, Identification of the promoter region and the transcriptional regulatory sequence of the evgAS operon of Escherichia coli., Biosci Biotechnol Biochem 62(2):286-90

 [4] Krin E., Danchin A., Soutourina O., 2010, Decrypting the H-NS-dependent regulatory cascade of acid stress resistance in Escherichia coli., BMC Microbiol 10:273


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