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MetJ,MetR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
MetR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator MetR
Gene name(s): metR
Functional conformation(s): MetR-L-homocysteine , MetR
Coregulator(s): FNR, Fur, MetJ, MetR, NsrR, OxyR, PurR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
MetJ Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): B3938, MetJ-S-adenosylmethionine, MetJ-SAM
Gene name(s): metJ
Functional conformation(s): MetJ , MetJ-adenine , MetJ-MTA , MetJ-adenosylmethionine
Coregulator(s): CRP, HypT, MetJ, MetR, OxyR, PhoP
Summary: TF Summary ...[more]

REGULATION EXERTED BY MetJ,MetR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
MetJ repressor MetR repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
MetR-L-homocysteine repressor metRp2 metR 4012815 4012829 16.0 tcatgccgaaGTGAAGGACTTTCATgatcgaagta [BPP]
[GEA]
[HIBSCS]
[1]
[2]
[3]
[4]
[5]
MetJ-adenosylmethionine repressor metRp2 metR 4012992 4013007 -162.5 ttttgaatttAGGGAAGGCGGCAAGTttattcatcc [BPP] [1]
MetJ-adenosylmethionine repressor metRp2 metR 4012877 4012892 -47.5 gccgtccagaTGTTTACACATCCATAattggcggtt [BPP] [1]
MetR-L-homocysteine repressor metRp2 metR 4012836 4012850 -6.0 tattcctcaaGCGCAAATTATTCATgccgaagtga [BPP]
[GEA]
[1]
[2]
[3]
[4]

Evidence: [BPP] Binding of purified proteins
[GEA] Gene expression analysis
[HIBSCS] Human inference based on similarity to consensus sequences
Reference(s): [1] Cai XY., et al., 1989
[2] Cai XY., et al., 1989
[3] Jafri S., et al., 1995
[4] Maxon ME., et al., 1989
[5] Weissbach H., et al., 1991



Reference(s)    

 [1] Cai XY., Maxon ME., Redfield B., Glass R., Brot N., Weissbach H., 1989, Methionine synthesis in Escherichia coli: effect of the MetR protein on metE and metH expression., Proc Natl Acad Sci U S A 86(12):4407-11

 [2] Cai XY., Redfield B., Maxon M., Weissbach H., Brot N., 1989, The effect of homocysteine on MetR regulation of metE, metR and metH expression in vitro., Biochem Biophys Res Commun 163(1):79-83

 [3] Jafri S., Urbanowski ML., Stauffer GV., 1995, A mutation in the rpoA gene encoding the alpha subunit of RNA polymerase that affects metE-metR transcription in Escherichia coli., J Bacteriol 177(3):524-9

 [4] Maxon ME., Redfield B., Cai XY., Shoeman R., Fujita K., Fisher W., Stauffer G., Weissbach H., Brot N., 1989, Regulation of methionine synthesis in Escherichia coli: effect of the MetR protein on the expression of the metE and metR genes., Proc Natl Acad Sci U S A 86(1):85-9

 [5] Weissbach H., Brot N., 1991, Regulation of methionine synthesis in Escherichia coli., Mol Microbiol 5(7):1593-7


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