RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


H-NS,McbR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
H-NS      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): BglY, Cur, DNA-binding protein HLP-II (HU, BH2, HD, NS), DNA-binding transcriptional dual regulator H-NS, Drc, DrdX, Drs, FimG, Hns, HnsA, Irk, MsyA, OsmZ, PilG, TopS, TopX, VirR
Gene name(s): hns
Functional conformation(s): H-NS
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, BasR, CRP, CadC, CaiF, CdaR, CpxR, Cra, CsgD, CspA, CysB, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, FNR, Fis, FlhDC, FliZ, Fur, GadE, GadW, GadX, GalR, GalS, GlaR, GutM, H-NS, HU, HdfR, HypT, IHF, LacI, LeuO, LrhA, Lrp, MarA, MatA, McbR, MlrA, MntR, MqsA, NagC, NanR, NarL, NarP, NhaR, NrdR, NsrR, OmpR, OxyR, PhoB, PhoP, QseB, RcdA, RcsB, Rob, RstA, RutR, SdiA, SlyA, SoxS, SrlR, StpA, SutR, TorR, UvrY, YdeO, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
McbR      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator McbR, YncC
Gene name(s): mcbR
Functional conformation(s): McbR
Coregulator(s): ArcA, CRP, H-NS, McbR, RcdA, SdiA, SlyA, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY H-NS,McbR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
H-NS repressor McbR activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
McbR activator yciGp yciE , yciF , yciG 1316170 1316191 -88.5 tcctcaggtaATTGTTAATATATCCAGAATGTtcctcaaaat [BPP]
[GEA]
[1]
[2]
McbR activator yciGp yciE , yciF , yciG 1316149 1316170 -67.5 atccagaatgTTCCTCAAAATATATTTTCCCTctatcttctc [BPP]
[GEA]
[1]
[2]
H-NS repressor yciGp yciE , yciF , yciG 1316153 1316163 -65.5 atgttcctcaAAATATATTTTccctctatct [BPP]
[GEA]
[HIBSCS]
[1]
[3]
H-NS repressor yciGp yciE , yciF , yciG 1316176 1316186 -88.5 aggtaattgtTAATATATCCAgaatgttcct [BPP]
[GEA]
[HIBSCS]
[1]
[3]

Evidence: [BPP] Binding of purified proteins
[GEA] Gene expression analysis
[HIBSCS] Human inference based on similarity to consensus sequences
Reference(s): [1] Beraud M., et al., 2010
[2] Lord DM., et al., 2014
[3] Yoshida T., et al., 1993



Reference(s)    

 [1] Beraud M., Kolb A., Monteil V., D'Alayer J., Norel F., 2010, A proteomic analysis reveals differential regulation of the σ(S)-dependent yciGFE(katN) locus by YncC and H-NS in Salmonella and Escherichia coli K-12., Mol Cell Proteomics 9(12):2601-16

 [2] Lord DM., Uzgoren Baran A., Soo VW., Wood TK., Peti W., Page R., 2014, McbR/YncC: implications for the mechanism of ligand and DNA binding by a bacterial GntR transcriptional regulator involved in biofilm formation., Biochemistry 53(46):7223-31

 [3] Yoshida T., Ueguchi C., Yamada H., Mizuno T., 1993, Function of the Escherichia coli nucleoid protein, H-NS: molecular analysis of a subset of proteins whose expression is enhanced in a hns deletion mutant., Mol Gen Genet 237(1-2):113-22


RegulonDB