RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


Fur,H-NS regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
H-NS      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): BglY, Cur, DNA-binding protein HLP-II (HU, BH2, HD, NS), DNA-binding transcriptional dual regulator H-NS, Drc, DrdX, Drs, FimG, Hns, HnsA, Irk, MsyA, OsmZ, PilG, TopS, TopX, VirR
Gene name(s): hns
Functional conformation(s): H-NS
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, BasR, CRP, CadC, CaiF, CdaR, CpxR, Cra, CsgD, CspA, CysB, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, FNR, Fis, FlhDC, FliZ, Fur, GadE, GadW, GadX, GalR, GalS, GlaR, GutM, H-NS, HU, HdfR, HypT, IHF, LacI, LeuO, LrhA, Lrp, MarA, MatA, McbR, MlrA, MntR, MqsA, NagC, NanR, NarL, NarP, NhaR, NrdR, NsrR, OmpR, OxyR, PhoB, PhoP, QseB, RcdA, RcsB, Rob, RstA, RutR, SdiA, SlyA, SoxS, SrlR, StpA, SutR, TorR, UvrY, YdeO, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
Fur Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External sensing using transported metabolites
Synonym(s): DNA-binding transcriptional dual regulator Fur
Gene name(s): fur
Functional conformation(s): Fur-Fe2+ , Fur-Mn2+ , Fur
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, CRP, CdaR, CpxR, Cra, CusR, EnvY, FNR, Fis, FliZ, Fur, GadE, GadX, H-NS, HdfR, HprR, HypT, IHF, IscR, LrhA, Lrp, MarA, MatA, MetR, MntR, ModE, MqsA, Nac, NagC, NfeR, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PhoB, PurR, QseB, RcnR, RcsB, Rob, RstA, RutR, SlyA, SoxR, SoxS, YjjQ, Zur, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY Fur,H-NS Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
Fur repressor H-NS repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
Fur-Fe2+ repressor gspCp3 gspC , gspD , gspE , gspF , gspG , gspH , gspI , gspJ , gspK , gspL , gspM , gspO 3455677 3455695 156.0 gattatttttAATGTGAATTATTTCCATAcaactatagt [BPP]
[HIBSCS]
[1]
H-NS repressor gspCp3 gspC , gspD , gspE , gspF , gspG , gspH , gspI , gspJ , gspK , gspL , gspM , gspO         [BPP]
[GEA]
[2]
Fur activator H-NS repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
Fur-Fe2+ activator ftnAp ftnA 1988584 1988602 -89.0 tgattaaagaAATAGCGGTAATGCGTTTTattcccattc [BPP]
[GEA]
[HIBSCS]
[3]
Fur-Fe2+ activator ftnAp ftnA 1988596 1988614 -77.0 tagcggtaatGCGTTTTATTCCCATTCGTatttttaata [BPP]
[GEA]
[HIBSCS]
[3]
Fur-Fe2+ activator ftnAp ftnA 1988608 1988626 -65.0 gttttattccCATTCGTATTTTTAATAATtgaagtttat [BPP]
[GEA]
[HIBSCS]
[3]
H-NS repressor ftnAp ftnA 1988546 1988556 -131.5 ctttctctaaATATTTTAATCagcgagggga [BPP]
[GEA]
[3]
H-NS repressor ftnAp ftnA 1988571 1988591 -101.5 aggggatcttCGCTGATTAAAGAAATAGCGGtaatgcgttt [BPP]
[GEA]
[3]
H-NS repressor ftnAp ftnA 1988609 1988644 -56.0 ttttattcccATTCGTATTTTTAATAATTGAAGTTTATATTTTACCttttgcaaat [BPP]
[GEA]
[3]
H-NS repressor ftnAp ftnA 1988646 1988678 -20.5 tattttacctTTTGCAAATAATAAAATAACAAATTATAGTGACgccacagcaa [BPP]
[GEA]
[3]
H-NS repressor ftnAp ftnA 1988687 1988707 15.5 acgccacagcAACAAATATAACCTTTGTGGAgcactatcat [BPP]
[GEA]
[3]
Fur-Fe2+ activator ftnAp ftnA 1988590 1988609 -83.0 aagaaatagcGGTAATGCGTTTTATTCCCAttcgtatttt [BPP]
[GEA]
[HIBSCS]
[3]
Fur-Fe2+ activator ftnAp ftnA 1988602 1988620 -71.0 taatgcgtttTATTCCCATTCGTATTTTTaataattgaa [BPP]
[GEA]
[HIBSCS]
[3]
H-NS repressor ftnAp ftnA 1988590 1988609 -83.0 aagaaatagcGGTAATGCGTTTTATTCCCAttcgtatttt [BPP]
[GEA]
[3]

Evidence: [BPP] Binding of purified proteins
[HIBSCS] Human inference based on similarity to consensus sequences
[GEA] Gene expression analysis
Reference(s): [1] Chen Z., et al., 2007
[2] Francetic O., et al., 2000
[3] Nandal A., et al., 2010



Reference(s)    

 [1] Chen Z., Lewis KA., Shultzaberger RK., Lyakhov IG., Zheng M., Doan B., Storz G., Schneider TD., 2007, Discovery of Fur binding site clusters in Escherichia coli by information theory models., Nucleic Acids Res 35(20):6762-77

 [2] Francetic O., Belin D., Badaut C., Pugsley AP., 2000, Expression of the endogenous type II secretion pathway in Escherichia coli leads to chitinase secretion., EMBO J 19(24):6697-703

 [3] Nandal A., Huggins CC., Woodhall MR., McHugh J., Rodriguez-Quinones F., Quail MA., Guest JR., Andrews SC., 2010, Induction of the ferritin gene (ftnA) of Escherichia coli by Fe(2+)-Fur is mediated by reversal of H-NS silencing and is RyhB independent., Mol Microbiol 75(3):637-57


RegulonDB