RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


ArgR,H-NS regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
H-NS      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): BglY, Cur, DNA-binding protein HLP-II (HU, BH2, HD, NS), DNA-binding transcriptional dual regulator H-NS, Drc, DrdX, Drs, FimG, Hns, HnsA, Irk, MsyA, OsmZ, PilG, TopS, TopX, VirR
Gene name(s): hns
Functional conformation(s): H-NS
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, BasR, CRP, CadC, CaiF, CdaR, CpxR, Cra, CsgD, CspA, CysB, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, FNR, Fis, FlhDC, FliZ, Fur, GadE, GadW, GadX, GalR, GalS, GlaR, GutM, H-NS, HU, HdfR, HypT, IHF, LacI, LeuO, LrhA, Lrp, MarA, MatA, McbR, MlrA, MntR, MqsA, NagC, NanR, NarL, NarP, NhaR, NrdR, NsrR, OmpR, OxyR, PhoB, PhoP, QseB, RcdA, RcsB, Rob, RstA, RutR, SdiA, SlyA, SoxS, SrlR, StpA, SutR, TorR, UvrY, YdeO, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
ArgR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional dual regulator ArgR, XerA
Gene name(s): argR
Functional conformation(s): ArgR-L-arginine , ArgR
Coregulator(s): AdiY, ArgR, CRP, DksA-ppGpp, FNR, Fur, GadE, H-NS, HdfR, IHF, Lrp, Nac, NtrC, PhoP, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY ArgR,H-NS Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
ArgR repressor H-NS activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
ArgR-L-arginine repressor hisJp hisP , hisM , hisQ , hisJ 2426891 2426909 -62.5 taagcattttTAATGAAAAATAATACGTCtaacggggcg [AIBSCS]
[BPP]
[GEA]
[SM]
[1]
[2]
[3]
ArgR-L-arginine repressor hisJp hisP , hisM , hisQ , hisJ 2426912 2426930 -83.5 tggtgcattgAAATGCATACTTAAGCATTtttaatgaaa [BPP]
[GEA]
[SM]
[2]
H-NS activator hisJp hisP , hisM , hisQ , hisJ         [GEA] [4]

Evidence: [AIBSCS] Automated inference based on similarity to consensus sequences
[BPP] Binding of purified proteins
[GEA] Gene expression analysis
[SM] Site mutation
Reference(s): [1] Caldara M., et al., 2006
[2] Caldara M., et al., 2007
[3] Makarova KS., et al., 2001
[4] White-Ziegler CA., et al., 2007



Reference(s)    

 [1] Caldara M., Charlier D., Cunin R., 2006, The arginine regulon of Escherichia coli: whole-system transcriptome analysis discovers new genes and provides an integrated view of arginine regulation., Microbiology 152(Pt 11):3343-54

 [2] Caldara M., Minh PN., Bostoen S., Massant J., Charlier D., 2007, ArgR-dependent Repression of Arginine and Histidine Transport Genes in Escherichia coli K-12., J Mol Biol 373(2):251-67

 [3] Makarova KS., Mironov AA., Gelfand MS., 2001, Conservation of the binding site for the arginine repressor in all bacterial lineages., Genome Biol 2(4):RESEARCH0013

 [4] White-Ziegler CA., Malhowski AJ., Young S., 2007, Human body temperature (37degrees C) increases the expression of iron, carbohydrate, and amino acid utilization genes in Escherichia coli K-12., J Bacteriol 189(15):5429-40


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