RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


H-NS,LeuO,LrhA,SlyA,ppGpp regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
H-NS      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): BglY, Cur, DNA-binding protein HLP-II (HU, BH2, HD, NS), DNA-binding transcriptional dual regulator H-NS, Drc, DrdX, Drs, FimG, Hns, HnsA, Irk, MsyA, OsmZ, PilG, TopS, TopX, VirR
Gene name(s): hns
Functional conformation(s): H-NS
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, BasR, CRP, CadC, CaiF, CdaR, CpxR, Cra, CsgD, CspA, CysB, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, FNR, Fis, FlhDC, FliZ, Fur, GadE, GadW, GadX, GalR, GalS, GlaR, GutM, H-NS, HU, HdfR, HypT, IHF, LacI, LeuO, LrhA, Lrp, MarA, MatA, McbR, MlrA, MntR, MqsA, NagC, NanR, NarL, NarP, NhaR, NrdR, NsrR, OmpR, OxyR, PhoB, PhoP, QseB, RcdA, RcsB, Rob, RstA, RutR, SdiA, SlyA, SoxS, SrlR, StpA, SutR, TorR, UvrY, YdeO, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
LrhA      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator LrhA, GenR
Gene name(s): lrhA
Functional conformation(s): LrhA
Coregulator(s): AcrR, CRP, FliZ, Fur, H-NS, HdfR, IHF, LeuO, LrhA, Lrp, MatA, OmpR, QseB, RcsB, SlyA, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
SlyA Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator SlyA
Gene name(s): slyA
Functional conformation(s): SlyA
Coregulator(s): ArcA, CRP, FNR, Fis, Fur, H-NS, IHF, LeuO, LrhA, McbR, PaaX, PhoP, RcdA, SdiA, SlyA, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
LeuO Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator LeuO
Gene name(s): leuO
Functional conformation(s): LeuO
Coregulator(s): CRP, CadC, DksA-ppGpp, FNR, Fis, H-NS, LeuO, LrhA, MlrA, OmpR, RcsB, SlyA, StpA, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY H-NS,LeuO,LrhA,SlyA,ppGpp Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
H-NS repressor LeuO activator LrhA activator SlyA activator ppGpp activation    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
H-NS repressor leuOp leuO 84085 84099 -96.0 aaattaattaTTAAATAAGCACATTtaatccattt [GEA]
[HIBSCS]
[1]
[2]
LeuO activator leuOp leuO 84122 84142 -56.0 tagatgattgAGTATTCGCGGTAGTTATGATtagattgttt [BPP]
[GEA]
[IC]
[1]
[2]
LrhA activator leuOp leuO 84000 84091 -143.0 attatatgttTTGCGATTTTTTTTGATATTGATTTGGTGAATATTATTGATCAATTAATGTTAAGAATTAATGCATTAAATATATAAATTAATTATTAAATAagcacattta [BPP]
[GEA]
[3]
SlyA activator leuOp leuO 84065 84076 -117.5 aattaatgcaTTAAATATATAAattaattatt [AIBSCS]
[BPP]
[GEA]
[4]
SlyA activator leuOp leuO 84057 84068 -125.5 atgttaagaaTTAATGCATTAAatatataaat [AIBSCS]
[BPP]
[GEA]
[4]

Evidence: [GEA] Gene expression analysis
[HIBSCS] Human inference based on similarity to consensus sequences
[BPP] Binding of purified proteins
[IC] Inferred by curator
[AIBSCS] Automated inference based on similarity to consensus sequences
Reference(s): [1] Chen CC., et al., 2005
[2] Stratmann T., et al., 2012
[3] Breddermann H., et al., 2017
[4] Curran T., et al., 2017



Reference(s)    

 [1] Chen CC., Chou MY., Huang CH., Majumder A., Wu HY., 2005, A cis-spreading nucleoprotein filament is responsible for the gene silencing activity found in the promoter relay mechanism., J Biol Chem 280(6):5101-12

 [2] Stratmann T., Pul U., Wurm R., Wagner R., Schnetz K., 2012, RcsB-BglJ activates the Escherichia coli leuO gene, encoding an H-NS antagonist and pleiotropic regulator of virulence determinants., Mol Microbiol 83(6):1109-23

 [3] Breddermann H., Schnetz K., 2017, Activation of leuO by LrhA in Escherichia coli., Mol Microbiol

 [4] Curran T., Abacha F., Hibberd S., Rolfe M., Lacey M., Green J., 2017, Identification of new members of the Escherichia coli K-12 MG1655 SlyA regulon., Microbiology


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