RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


H-NS,LeuO,RcsB,StpA regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
H-NS      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): BglY, Cur, DNA-binding protein HLP-II (HU, BH2, HD, NS), DNA-binding transcriptional dual regulator H-NS, Drc, DrdX, Drs, FimG, Hns, HnsA, Irk, MsyA, OsmZ, PilG, TopS, TopX, VirR
Gene name(s): hns
Functional conformation(s): H-NS
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, BasR, CRP, CadC, CaiF, CdaR, CpxR, Cra, CsgD, CspA, CysB, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, FNR, Fis, FlhDC, FliZ, Fur, GadE, GadW, GadX, GalR, GalS, GlaR, GutM, H-NS, HU, HdfR, HypT, IHF, LacI, LeuO, LrhA, Lrp, MarA, MatA, McbR, MlrA, MntR, MqsA, NagC, NanR, NarL, NarP, NhaR, NrdR, NsrR, OmpR, OxyR, PhoB, PhoP, QseB, RcdA, RcsB, Rob, RstA, RutR, SdiA, SlyA, SoxS, SrlR, StpA, SutR, TorR, UvrY, YdeO, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
RcsB Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional activator RcsB, RcsB response regulator
Gene name(s): rcsB
Functional conformation(s): RcsB-Pasp56
Coregulator(s): AcrR, AdiY, ArcA, BasR, CRP, CpxR, Cra, CsgD, EvgA, FNR, Fis, FliZ, Fur, GadE, GadW, GadX, GlrR, H-NS, HdfR, IHF, LeuO, LexA, LrhA, Lrp, MarA, MatA, MlrA, MqsA, NagC, NarL, NarP, NhaR, NtrC, OmpR, PhoP, QseB, RcdA, RcsB, RstA, StpA, TorR, UvrY, YdeO, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
LeuO Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator LeuO
Gene name(s): leuO
Functional conformation(s): LeuO
Coregulator(s): CRP, CadC, DksA-ppGpp, FNR, Fis, H-NS, LeuO, LrhA, MlrA, OmpR, RcsB, SlyA, StpA, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
StpA      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional repressor StpA with RNA chaperone activity, H-NS-like DNA-binding transcriptional repressor with RNA chaperone activity, HnsB
Gene name(s): stpA
Functional conformation(s): StpA
Coregulator(s): CRP, Fis, H-NS, LeuO, Lrp, RcsB, StpA
Summary: TF Summary ...[more]

REGULATION EXERTED BY H-NS,LeuO,RcsB,StpA Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
H-NS repressor LeuO dual RcsB activator StpA repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
RcsB-BglJ activator leuOp2 leuO 84236 84255 -58.5 cagaacccgtATCTTTATGTTTTCCGAATTttactcattt [GEA]
[HIBSCS]
[SM]
[1]
H-NS repressor leuOp2 leuO 84085 84099 -212.0 aaattaattaTTAAATAAGCACATTtaatccattt [BPP]
[GEA]
[HIBSCS]
[2]
[1]
LeuO dual leuOp2 leuO 84122 84142 -172.0 tagatgattgAGTATTCGCGGTAGTTATGATtagattgttt [BPP]
[GEA]
[2]
[1]
LeuO dual leuOp2 leuO 84099 84119 -195.0 ataagcacatTTAATCCATTTTGTAGATGATtgagtattcg [BPP]
[GEA]
[IC]
[1]
LeuO dual leuOp2 leuO 84040 84060 -254.0 atattattgaTCAATTAATGTTAAGAATTAAtgcattaaat [BPP]
[GEA]
[IC]
[1]
LeuO dual leuOp2 leuO 84014 84034 -280.0 gattttttttGATATTGATTTGGTGAATATTattgatcaat [BPP]
[GEA]
[IC]
[1]
StpA repressor leuOp2 leuO         [GEA] [1]
LeuO dual leuOp2 leuO 84040 84060 -254.0 atattattgaTCAATTAATGTTAAGAATTAAtgcattaaat [BPP]
[GEA]
[IC]
[1]
LeuO dual leuOp2 leuO 84099 84119 -195.0 ataagcacatTTAATCCATTTTGTAGATGATtgagtattcg [BPP]
[GEA]
[IC]
[1]
LeuO dual leuOp2 leuO 84014 84034 -280.0 gattttttttGATATTGATTTGGTGAATATTattgatcaat [BPP]
[GEA]
[IC]
[1]
LeuO dual leuOp2 leuO 84122 84142 -172.0 tagatgattgAGTATTCGCGGTAGTTATGATtagattgttt [BPP]
[GEA]
[2]
[1]

Evidence: [GEA] Gene expression analysis
[HIBSCS] Human inference based on similarity to consensus sequences
[SM] Site mutation
[BPP] Binding of purified proteins
[IC] Inferred by curator
Reference(s): [1] Stratmann T., et al., 2012
[2] Chen CC., et al., 2005



Reference(s)    

 [1] Stratmann T., Pul U., Wurm R., Wagner R., Schnetz K., 2012, RcsB-BglJ activates the Escherichia coli leuO gene, encoding an H-NS antagonist and pleiotropic regulator of virulence determinants., Mol Microbiol 83(6):1109-23

 [2] Chen CC., Chou MY., Huang CH., Majumder A., Wu HY., 2005, A cis-spreading nucleoprotein filament is responsible for the gene silencing activity found in the promoter relay mechanism., J Biol Chem 280(6):5101-12


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