RegulonDB RegulonDB 10.7: Regulon Form
   
   


ArcA,CRP,Fis,Mlc,SoxS regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
Fis Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): DNA-binding transcriptional dual regulator Fis, Nbp, site-specific DNA inversion stimulation factor
Gene name(s): fis
Functional conformation(s): Fis
Coregulator(s): AcrR, AdiY, AppY, ArcA, ArgP, BasR, CRP, CpxR, Cra, CreB, CspA, CusR, CytR, DeoR, DksA, DksA-ppGpp, DnaA, FNR, FadR, Fis, FlhDC, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GlcC, GlpR, H-NS, HprR, IHF, IscR, LeuO, Lrp, MalT, MarA, MarR, MazE, MazE-MazF, Mlc, MntR, ModE, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PepA, PurR, RcsB, RcsB-BglJ, Rob, RstA, RutR, SlyA, SoxS, StpA, TorR, XylR, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP , CRP-cAMP
Coregulator(s): AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BtsR, CRP, CRP-Sxy, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FucR, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsAB, RcsB, RcsB-BglJ, RhaR, RhaS, Rob, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YiaJ, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
Mlc Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional repressor Mlc, DgsA
Gene name(s): mlc
Functional conformation(s): Mlc-EIIGlC , Mlc
Coregulator(s): ArcA, CRP, Cra, Fis, Lrp, Mlc, NagC, SoxS
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
SoxS Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator SoxS, regulation of superoxide response regulon
Gene name(s): soxS
Functional conformation(s): SoxS
Coregulator(s): AcrR, ArcA, BasR, CRP, CpxR, Cra, DnaA, EnvR, FNR, Fis, Fur, H-NS, HU, IHF, Lrp, MarA, MarR, Mlc, MprA, OmpR, OxyR, PhoP, Rob, SoxR, SoxS, Zur
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
ArcA Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class External-Two-component systems
Synonym(s): ArcA response regulator, CpxC, DNA-binding transcriptional dual regulator ArcA, Dye, FexA, Msp, Seg, SfrA, dye resistance protein
Gene name(s): arcA
Functional conformation(s): ArcA , ArcA-Phosphorylated
Coregulator(s): AdiY, AppY, ArcA, BetI, CRP, CadC, CaiF, Cra, CusR, CysB, DcuR, DksA-ppGpp, DnaA, DpiA, FNR, FadR, Fis, FlhDC, Fur, GadE, GadE-RcsB, GadW, GadX, GatR, GlcC, GlpR, H-NS, HipB, HprR, HypT, IHF, IclR, IscR, LexA, LldR, Lrp, MarA, McbR, Mlc, ModE, MqsA, NarL, NarP, NsrR, NtrC, OmpR, PdhR, PhoP, PuuR, RcdA, RcsB, RhaS, Rob, RutR, SdiA, SlyA, SoxR, SoxS, TorR, TreR, YdeO, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY ArcA,CRP,Fis,Mlc,SoxS Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
ArcA repressor CRP activator Fis dual Mlc repressor SoxS activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CRP-cAMP activator ptsGp1 ptsG 1157661 1157682 -94.5 acgtttgaaaTATTGTGACATATGTTTTGTCAaaatgtgcaa [BPP]
[GEA]
[1]
CRP-cAMP activator ptsGp1 ptsG 1157715 1157736 -40.5 tctgaagttgAAACGTGATAGCCGTCAAACAAattggcactg [AIBSCS]
[BPP]
[GEA]
[2]
[3]
ArcA-Phosphorylated repressor ptsGp1 ptsG 1157674 1157688 -85.0 tgtgacatatGTTTTGTCAAAATGTgcaacttctc [BPP]
[GEA]
[4]
ArcA-Phosphorylated repressor ptsGp1 ptsG 1157760 1157774 2.0 tattttactcTGTGTAATAAATAAAgggcgcttag [BPP]
[GEA]
[4]
ArcA-Phosphorylated repressor ptsGp1 ptsG 1157711 1157725 -48.0 atgatctgaaGTTGAAACGTGATAGccgtcaaaca [BPP]
[GEA]
[4]
Mlc repressor ptsGp1 ptsG 1157749 1157771 -6.0 tggcactgaaTTATTTTACTCTGTGTAATAAATaaagggcgct [APIORCISFBSCS]
[BPP]
[GEA]
[5]
[2]
[1]
SoxS activator ptsGp1 ptsG 1157673 1157693 -83.5 ttgtgacataTGTTTTGTCAAAATGTGCAACttctccaatg [APIORCISFBSCS]
[BPP]
[GEA]
[6]
Fis activator ptsGp1 ptsG 1157761 1157775 3.0 attttactctGTGTAATAAATAAAGggcgcttaga [BPP]
[GEA]
[1]
Fis activator ptsGp1 ptsG 1157740 1157754 -19.0 caaacaaattGGCACTGAATTATTTtactctgtgt [BPP]
[GEA]
[1]
Fis repressor ptsGp1 ptsG 1157614 1157628 -145.0 gctaaaacgaGTAAAGTTCACCGCCgaaaattggg [BPP]
[GEA]
[1]
Fis repressor ptsGp1 ptsG 1157640 1157654 -119.0 aaaattgggcGGTGAATAACCACGTttgaaatatt [BPP]
[GEA]
[1]
Fis repressor ptsGp1 ptsG 1157679 1157693 -80.0 catatgttttGTCAAAATGTGCAACttctccaatg [BPP]
[GEA]
[1]
Fis repressor ptsGp1 ptsG 1157761 1157775 3.0 attttactctGTGTAATAAATAAAGggcgcttaga [BPP]
[GEA]
[1]
Fis repressor ptsGp1 ptsG 1157740 1157754 -19.0 caaacaaattGGCACTGAATTATTTtactctgtgt [BPP]
[GEA]
[1]

Evidence: [BPP] Binding of purified proteins
[GEA] Gene expression analysis
[AIBSCS] Automated inference based on similarity to consensus sequences
[APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.
Reference(s): [1] Shin D., et al., 2003
[2] Plumbridge J. 1998
[3] Zheng D., et al., 2004
[4] Jeong JY., et al., 2004
[5] Plumbridge J. 2001
[6] Rungrassamee W., et al., 2008



Reference(s)    

 [1] Shin D., Cho N., Heu S., Ryu S., 2003, Selective regulation of ptsG expression by Fis. Formation of either activating or repressing nucleoprotein complex in response to glucose., J Biol Chem 278(17):14776-81

 [2] Plumbridge J., 1998, Expression of ptsG, the gene for the major glucose PTS transporter in Escherichia coli, is repressed by Mlc and induced by growth on glucose., Mol Microbiol 29(4):1053-63

 [3] Zheng D., Constantinidou C., Hobman JL., Minchin SD., 2004, Identification of the CRP regulon using in vitro and in vivo transcriptional profiling., Nucleic Acids Res 32(19):5874-93

 [4] Jeong JY., Kim YJ., Cho N., Shin D., Nam TW., Ryu S., Seok YJ., 2004, Expression of ptsG Encoding the Major Glucose Transporter Is Regulated by ArcA in Escherichia coli., J Biol Chem 279(37):38513-8

 [5] Plumbridge J., 2001, DNA binding sites for the Mlc and NagC proteins: regulation of nagE, encoding the N-acetylglucosamine-specific transporter in Escherichia coli., Nucleic Acids Res 29(2):506-14

 [6] Rungrassamee W., Liu X., Pomposiello PJ., 2008, Activation of glucose transport under oxidative stress in Escherichia coli., Arch Microbiol 190(1):41-9


RegulonDB