RegulonDB RegulonDB 10.7: Regulon Form
   
   


Fis,Mlc regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
Fis Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): DNA-binding transcriptional dual regulator Fis, Nbp, site-specific DNA inversion stimulation factor
Gene name(s): fis
Functional conformation(s): Fis
Coregulator(s): AcrR, AdiY, AppY, ArcA, ArgP, BasR, CRP, CpxR, Cra, CreB, CspA, CusR, CytR, DeoR, DksA, DksA-ppGpp, DnaA, FNR, FadR, Fis, FlhDC, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GlcC, GlpR, H-NS, HprR, IHF, IscR, LeuO, Lrp, MalT, MarA, MarR, MazE, MazE-MazF, Mlc, MntR, ModE, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PepA, PurR, RcsB, RcsB-BglJ, Rob, RstA, RutR, SlyA, SoxS, StpA, TorR, XylR, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
Mlc Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional repressor Mlc, DgsA
Gene name(s): mlc
Functional conformation(s): Mlc-EIIGlC , Mlc
Coregulator(s): ArcA, CRP, Cra, Fis, Lrp, Mlc, NagC, SoxS
Summary: TF Summary ...[more]

REGULATION EXERTED BY Fis,Mlc Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
Fis repressor Mlc repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
Mlc repressor ptsGp2 ptsG 1157580 1157602 -35.0 gttgaatgagTTTTTTTAAAGCTCGTAATTAATggctaaaacg [APIORCISFBSCS]
[BPP]
[GEA]
[1]
[2]
Fis repressor ptsGp2 ptsG 1157614 1157628 -5.0 gctaaaacgaGTAAAGTTCACCGCCgaaaattggg [BPP]
[GEA]
[3]
Fis repressor ptsGp2 ptsG 1157640 1157654 22.0 aaaattgggcGGTGAATAACCACGTttgaaatatt [BPP]
[GEA]
[3]
Fis repressor ptsGp2 ptsG 1157679 1157693 61.0 catatgttttGTCAAAATGTGCAACttctccaatg [BPP]
[GEA]
[3]
Fis repressor ptsGp2 ptsG 1157740 1157754 122.0 caaacaaattGGCACTGAATTATTTtactctgtgt [BPP]
[GEA]
[3]
Fis repressor ptsGp2 ptsG 1157761 1157775 143.0 attttactctGTGTAATAAATAAAGggcgcttaga [BPP]
[GEA]
[3]

Evidence: [APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.
[BPP] Binding of purified proteins
[GEA] Gene expression analysis
Reference(s): [1] Plumbridge J. 2001
[2] Plumbridge J. 1998
[3] Shin D., et al., 2003



Reference(s)    

 [1] Plumbridge J., 2001, DNA binding sites for the Mlc and NagC proteins: regulation of nagE, encoding the N-acetylglucosamine-specific transporter in Escherichia coli., Nucleic Acids Res 29(2):506-14

 [2] Plumbridge J., 1998, Expression of ptsG, the gene for the major glucose PTS transporter in Escherichia coli, is repressed by Mlc and induced by growth on glucose., Mol Microbiol 29(4):1053-63

 [3] Shin D., Cho N., Heu S., Ryu S., 2003, Selective regulation of ptsG expression by Fis. Formation of either activating or repressing nucleoprotein complex in response to glucose., J Biol Chem 278(17):14776-81


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