RegulonDB RegulonDB 10.7: Regulon Form
   
   


CRP,GntR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP , CRP-cAMP
Coregulator(s): AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BtsR, CRP, CRP-Sxy, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FucR, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsAB, RcsB, RcsB-BglJ, RhaR, RhaS, Rob, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YiaJ, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
GntR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional repressor GntR
Gene name(s): gntR
Functional conformation(s): GntR-D-gluconate , GntR
Coregulator(s): CRP, Cra, GntR, IdnR, KdgR
Summary: TF Summary ...[more]

REGULATION EXERTED BY CRP,GntR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CRP activator GntR repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CRP-cAMP activator gntTp1 gntT 3546323 3546344 -71.5 ttccccgcgaTAATATGACCAACCTCTCATAAtttaaattta [APIORCISFBSCS]
[BPP]
[GEA]
[SM]
[TASES]
[1]
[2]
[3]
[4]
GntR repressor gntTp1 gntT 3546381 3546400 -14.5 ctcaaacgccAGATGTTACCCGTATCATTCacatgggtac [AIBSCS]
[APIORCISFBSCS]
[BPP]
[GEA]
[TASES]
[1]
[2]
[3]
[4]
[5]
GntR repressor gntTp1 gntT 3546522 3546541 127.5 gtcagaaaatTGACGTTACCCATAACAAATgaaaggccag [AIBSCS]
[APIORCISFBSCS]
[BPP]
[GEA]
[TASES]
[2]
[3]
[4]
[5]
CRP-cAMP activator gntTp3 gntT 3546323 3546344 -115.5 ttccccgcgaTAATATGACCAACCTCTCATAAtttaaattta [APIORCISFBSCS]
[BPP]
[GEA]
[SM]
[TASES]
[1]
[2]
[3]
[4]
GntR repressor gntTp3 gntT 3546522 3546541 83.5 gtcagaaaatTGACGTTACCCATAACAAATgaaaggccag [AIBSCS]
[APIORCISFBSCS]
[BPP]
[GEA]
[TASES]
[2]
[3]
[4]
[5]
GntR repressor gntTp3 gntT 3546381 3546400 -58.5 ctcaaacgccAGATGTTACCCGTATCATTCacatgggtac [AIBSCS]
[APIORCISFBSCS]
[BPP]
[GEA]
[TASES]
[1]
[2]
[3]
[4]
[5]
CRP-cAMP activator gntTp2 gntT 3546323 3546344 -112.5 ttccccgcgaTAATATGACCAACCTCTCATAAtttaaattta [APIORCISFBSCS]
[BPP]
[GEA]
[SM]
[TASES]
[1]
[2]
[3]
[4]
GntR repressor gntTp2 gntT 3546522 3546541 86.5 gtcagaaaatTGACGTTACCCATAACAAATgaaaggccag [AIBSCS]
[APIORCISFBSCS]
[BPP]
[GEA]
[TASES]
[2]
[3]
[4]
[5]
GntR repressor gntTp2 gntT 3546381 3546400 -55.5 ctcaaacgccAGATGTTACCCGTATCATTCacatgggtac [AIBSCS]
[APIORCISFBSCS]
[BPP]
[GEA]
[TASES]
[1]
[2]
[3]
[4]
[5]
CRP-cAMP activator gntXp yhgH , nfuA 3544615 3544636 -41.5 gcctaaccaaATGGCTTTATCAGGTGCCTGTTgcagcacggc [AIBSCS] [2]
[6]
GntR repressor gntXp yhgH , nfuA 3544642 3544661 -15.0 ctgttgcagcACGGCTTCGGCCATATCAGCaagtgacagc [AIBSCS] [6]

Evidence: [APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.
[BPP] Binding of purified proteins
[GEA] Gene expression analysis
[SM] Site mutation
[TASES] Traceable author statement to experimental support
[AIBSCS] Automated inference based on similarity to consensus sequences
Reference(s): [1] Izu H., et al., 1997
[2] Peekhaus N., et al., 1998
[3] Peekhaus N., et al., 1998
[4] Rodionov DA., et al., 2000
[5] Suvorova IA., et al., 2015
[6] Porco A., et al., 1998



Reference(s)    

 [1] Izu H., Kawai T., Yamada Y., Aoshima H., Adachi O., Yamada M., 1997, Characterization of the gntT gene encoding a high-affinity gluconate permease in Escherichia coli., Gene 199(1-2):203-10

 [2] Peekhaus N., Conway T., 1998, Positive and negative transcriptional regulation of the Escherichia coli gluconate regulon gene gntT by GntR and the cyclic AMP (cAMP)-cAMP receptor protein complex., J Bacteriol 180(7):1777-85

 [3] Peekhaus N., Conway T., 1998, What's for dinner?: Entner-Doudoroff metabolism in Escherichia coli., J Bacteriol 180(14):3495-502

 [4] Rodionov DA., Mironov AA., Rakhmaninova AB., Gelfand MS., 2000, Transcriptional regulation of transport and utilization systems for hexuronides, hexuronates and hexonates in gamma purple bacteria., Mol Microbiol 38(4):673-83

 [5] Suvorova IA., Korostelev YD., Gelfand MS., 2015, GntR Family of Bacterial Transcription Factors and Their DNA Binding Motifs: Structure, Positioning and Co-Evolution., PLoS One 10(7):e0132618

 [6] Porco A., Alonso G., Isturiz T., 1998, The gluconate high affinity transport of GntI in Escherichia coli involves a multicomponent complex system., J Basic Microbiol 38(5-6):395-404


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