RegulonDB RegulonDB 10.7: Regulon Form
   
   


GadW,GadX,RcsB regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
RcsB Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional activator RcsB, RcsB response regulator
Gene name(s): rcsB
Functional conformation(s): RcsB , RcsB-Pasp56
Coregulator(s): AdiY, ArcA, CRP, CadC, CpxR, EvgA, FNR, Fis, FliZ, GadE, GadE-RcsB, GadW, GadX, GlrR, H-NS, LeuO, LexA, Lrp, MarA, NagC, NarL, NarP, NhaR, NtrC, OmpR, PhoB, PhoP, RcsB, RcsB-BglJ, Rob, StpA, TorR, UvrY, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
GadX Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator GadX, YhiX
Gene name(s): gadX
Functional conformation(s): GadX
Coregulator(s): AdiY, AraC, ArcA, CRP, CadC, CspA, EvgA, FNR, Fis, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, H-NS, Lrp, MarA, MqsA, NagC, NtrC, OmpR, PhoB, PhoP, RcsB, RutR, SdiA, TorR, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
GadW Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator GadW, YhiW
Gene name(s): gadW
Functional conformation(s): GadW
Coregulator(s): AdiY, ArcA, CRP, EvgA, FNR, Fis, FliZ, GadE, GadE-RcsB, GadW, GadX, H-NS, Lrp, MarA, PhoB, PhoP, RcsB, RutR, SdiA, TorR, YdeO, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY GadW,GadX,RcsB Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
GadW repressor GadX activator RcsB activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
GadX activator gadYp gadY 3664825 3664844 -29.5 ttataaaaaaATGGCTGATCTTATTTCCAGtaaaagttat [GEA] [1]
GadX activator gadYp gadY 3664804 3664823 -50.5 cgcacagcgtATAGCTTATGTTTATAAAAAaatggctgat [GEA] [1]
RcsB-Pasp56 activator gadYp gadY         [GEA] [2]
GadW repressor gadYp gadY 3664825 3664844 -29.5 ttataaaaaaATGGCTGATCTTATTTCCAGtaaaagttat [GEA] [1]
GadW repressor gadYp gadY 3664804 3664823 -50.5 cgcacagcgtATAGCTTATGTTTATAAAAAaatggctgat [GEA] [1]

Evidence: [GEA] Gene expression analysis
Reference(s): [1] Tramonti A., et al., 2008
[2] Johnson MD., et al., 2011



Reference(s)    

 [1] Tramonti A., De Canio M., De Biase D., 2008, GadX/GadW-dependent regulation of the Escherichia coli acid fitness island: transcriptional control at the gadY-gadW divergent promoters and identification of four novel 42 bp GadX/GadW-specific binding sites., Mol Microbiol 70(4):965-82

 [2] Johnson MD., Burton NA., Gutierrez B., Painter K., Lund PA., 2011, RcsB Is Required for Inducible Acid Resistance in Escherichia coli and Acts at gadE-Dependent and -Independent Promoters., J Bacteriol 193(14):3653-6


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