RegulonDB RegulonDB 10.7: Regulon Form
   
   


H-NS,NhaR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
H-NS      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): BglY, Cur, DNA-binding protein HLP-II (HU, BH2, HD, NS), DNA-binding transcriptional dual regulator H-NS, Drc, DrdX, Drs, FimG, Hns, HnsA, Irk, MsyA, OsmZ, PilG, TopS, TopX, VirR
Gene name(s): hns
Functional conformation(s): H-NS
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, BasR, CRP, CadC, CaiF, CdaR, CpxR, Cra, CsgD, CspA, CysB, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, FNR, Fis, FlhDC, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GlaR, GutM, H-NS, HU, HdfR, HypT, IHF, LacI, LeuO, LrhA, Lrp, MarA, MatA, McbR, MlrA, MntR, MqsA, NagC, NanR, NarL, NarP, NhaR, NrdR, NsrR, OmpR, OxyR, PhoB, PhoP, QseB, RcdA, RcsAB, RcsB, RcsB-BglJ, Rob, RstA, RutR, SdiA, SlyA, SoxS, SrlR, StpA, SutR, TorR, UvrY, YdeO, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
NhaR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External sensing using transported metabolites
Synonym(s): AntO, DNA-binding transcriptional activator NhaR, YaaB
Gene name(s): nhaR
Functional conformation(s): NhaR , NhaR-Na+
Coregulator(s): H-NS, Lrp, NhaR, OmpR, RcsB
Summary: TF Summary ...[more]

REGULATION EXERTED BY H-NS,NhaR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
H-NS repressor NhaR activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
NhaR-Na+ activator nhaAp1 nhaA , nhaR 17384 17400 -66.0 ttcttcaataGCTCGTAAAAAACGAATtattcctaca [BCE]
[BPP]
[GEA]
[1]
[2]
[3]
[4]
[5]
NhaR-Na+ activator nhaAp1 nhaA , nhaR 17416 17432 -34.0 ctacactataATCTGATTTTAACGATGattcgtgcgg [BCE]
[BPP]
[GEA]
[1]
[2]
[4]
[5]
NhaR-Na+ activator nhaAp1 nhaA , nhaR 17447 17464 -3.0 gtgcggggtaAAATAGTAAAAACGATCTattcacctga [BCE]
[BPP]
[GEA]
[1]
[2]
[3]
[4]
[5]
NhaR-Na+ activator nhaAp1 nhaA , nhaR 17406 17422 -44.0 cgaattattcCTACACTATAATCTGATtttaacgatg [BCE]
[BPP]
[GEA]
[1]
[2]
[3]
[4]
[5]
H-NS repressor nhaAp1 nhaA , nhaR         [GEA] [3]

Evidence: [BCE] Binding of cellular extracts
[BPP] Binding of purified proteins
[GEA] Gene expression analysis
Reference(s): [1] Carmel O., et al., 1994
[2] Carmel O., et al., 1997
[3] Dover N., et al., 1996
[4] Dover N., et al., 2001
[5] Rahav-Manor O., et al., 1992



Reference(s)    

 [1] Carmel O., Dover N., Rahav-Manor O., Dibrov P., Kirsch D., Karpel R., Schuldiner S., Padan E., 1994, A single amino acid substitution (Glu134-->Ala) in NhaR1 increases the inducibility by Na+ of the product of nhaA, a Na+/H+ antiporter gene in Escherichia coli., EMBO J 13(8):1981-9

 [2] Carmel O., Rahav-Manor O., Dover N., Shaanan B., Padan E., 1997, The Na+-specific interaction between the LysR-type regulator, NhaR, and the nhaA gene encoding the Na+/H+ antiporter of Escherichia coli., EMBO J 16(19):5922-9

 [3] Dover N., Higgins CF., Carmel O., Rimon A., Pinner E., Padan E., 1996, Na+-induced transcription of nhaA, which encodes an Na+/H+ antiporter in Escherichia coli, is positively regulated by nhaR and affected by hns., J Bacteriol 178(22):6508-17

 [4] Dover N., Padan E., 2001, Transcription of nhaA, the main Na(+)/H(+) antiporter of Escherichia coli, is regulated by Na(+) and growth phase., J Bacteriol 183(2):644-53

 [5] Rahav-Manor O., Carmel O., Karpel R., Taglicht D., Glaser G., Schuldiner S., Padan E., 1992, NhaR, a protein homologous to a family of bacterial regulatory proteins (LysR), regulates nhaA, the sodium proton antiporter gene in Escherichia coli., J Biol Chem 267(15):10433-8


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