RegulonDB RegulonDB 10.7: Regulon Form
   
   


Cra,GntR,KdgR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
GntR      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional repressor GntR
Gene name(s): gntR
Functional conformation(s): GntR-D-gluconate , GntR
Coregulator(s): CRP, Cra, GntR, IdnR, KdgR
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
Cra      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator Cra, FruC, FruR, Shl
Gene name(s): cra
Functional conformation(s): Cra-;-D-fructose 1,6-bisphosphate , Cra-β-D-fructofuranose 1-phosphate , Cra , Cra-β-D-fructose 1,6-bisphosphate
Coregulator(s): AcrR, ArcA, BasR, BetI, CRP, CpxR, Cra, CsgD, CusR, DksA, FNR, Fis, FliZ, Fur, GadE, GlcC, GntR, H-NS, HprR, IHF, IclR, KdgR, Lrp, MarA, MarR, Mlc, MlrA, MqsA, NagC, NarL, NarP, OmpR, PdhR, PrpR, RcdA, RcsAB, Rob, RstA, SgrR, SoxS, TyrR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
KdgR      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional repressor KdgR, YebP
Gene name(s): kdgR
Functional conformation(s): KdgR
Coregulator(s): Cra, GntR, KdgR
Summary: TF Summary ...[more]

REGULATION EXERTED BY Cra,GntR,KdgR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
Cra repressor GntR repressor KdgR repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
Cra repressor eddp1 eda , edd 1934701 1934718 4.5 ttattacactGACTGAAACGTTTTTGCCctatgagctc [APIORCISFBSCS]
[BPP]
[GEA]
[SM]
[1]
GntR repressor eddp1 eda , edd 1934576 1934595 128.5 tatgaatccaCAATTGTTACGCGTAACAAAtcgaatcatt [APIORCISFBSCS]
[BPP]
[SM]
[2]
[3]
[4]
GntR repressor eddp1 eda , edd 1934797 1934816 -93.5 tcctttatggTTATTTTACCGGTAACATGAtcttgcgcag [AIBSCS]
[APIORCISFBSCS]
[BPP]
[2]
[3]
[4]
[5]
KdgR repressor eddp1 eda , edd 1934779 1934799 -76.0 accggtaacaTGATCTTGCGCAGATTGTAGAacaattttta [AIBSCS]
[APIORCISFBSCS]
[6]

Evidence: [APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.
[BPP] Binding of purified proteins
[GEA] Gene expression analysis
[SM] Site mutation
[AIBSCS] Automated inference based on similarity to consensus sequences
Reference(s): [1] Ramseier TM., et al., 1995
[2] Egan SE., et al., 1992
[3] Murray EL., et al., 2005
[4] Rodionov DA., et al., 2000
[5] Suvorova IA., et al., 2015
[6] Kaleta C., et al., 2010



Reference(s)    

 [1] Ramseier TM., Bledig S., Michotey V., Feghali R., Saier MH., 1995, The global regulatory protein FruR modulates the direction of carbon flow in Escherichia coli., Mol Microbiol 16(6):1157-69

 [2] Egan SE., Fliege R., Tong S., Shibata A., Wolf RE., Conway T., 1992, Molecular characterization of the Entner-Doudoroff pathway in Escherichia coli: sequence analysis and localization of promoters for the edd-eda operon., J Bacteriol 174(14):4638-46

 [3] Murray EL., Conway T., 2005, Multiple regulators control expression of the Entner-Doudoroff aldolase (Eda) of Escherichia coli., J Bacteriol 187(3):991-1000

 [4] Rodionov DA., Mironov AA., Rakhmaninova AB., Gelfand MS., 2000, Transcriptional regulation of transport and utilization systems for hexuronides, hexuronates and hexonates in gamma purple bacteria., Mol Microbiol 38(4):673-83

 [5] Suvorova IA., Korostelev YD., Gelfand MS., 2015, GntR Family of Bacterial Transcription Factors and Their DNA Binding Motifs: Structure, Positioning and Co-Evolution., PLoS One 10(7):e0132618

 [6] Kaleta C., Gohler A., Schuster S., Jahreis K., Guthke R., Nikolajewa S., 2010, Integrative inference of gene-regulatory networks in Escherichia coli using information theoretic concepts and sequence analysis., BMC Syst Biol 4:116


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