RegulonDB RegulonDB 10.8: Regulon Form
   
   


Fur,IscR,NrdR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
IscR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator IscR, YfhP
Gene name(s): iscR
Functional conformation(s): IscR-2Fe-2S , IscR
Coregulator(s): AppY, ArcA, Fis, Fur, IHF, IscR, NarL, NarP, NrdR, NsrR, OxyR, YdeO
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
NrdR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): NrdR transcriptional repressor, YbaD
Gene name(s): nrdR
Functional conformation(s): NrdR , NrdR-dATP , NrdR-ATP , NrdR-Zn2+
Coregulator(s): ArgP, CRP, DnaA, FNR, Fis, Fur, H-NS, IscR, NrdR
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
Fur Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External sensing using transported metabolites
Synonym(s): DNA-binding transcriptional dual regulator Fur
Gene name(s): fur
Functional conformation(s): Fur-Mn2+ , Fur , Fur-Fe2+
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, CRP, CdaR, CpxR, Cra, CusR, EnvY, FNR, Fis, FliZ, Fur, GadE, GadX, H-NS, HdfR, HprR, HypT, IHF, IscR, LrhA, Lrp, MarA, MatA, MetR, MntR, ModE, MqsA, Nac, NagC, NarL, NfeR, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PhoB, PurR, QseB, RcnR, RcsAB, Rob, RstA, RutR, SlyA, SoxR, SoxS, YjjQ, Zur, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY Fur,IscR,NrdR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
Fur repressor IscR activator NrdR repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
Fur-Fe2+ repressor nrdHp nrdH , nrdI , nrdE , nrdF 2800586 2800604 -61.0 catatccaggGTAATTTCGACCACTATTTgctatatatt [AIBSCS]
[CV(GEA)]
[GEA] 		[1]
[2]
NrdR-Zn2+ repressor nrdHp nrdH , nrdI , nrdE , nrdF 2800634 2800649 -14.5 aatcttttttCAACTACATCTAGTATctctgtatca [APIORCISFBSCS]
[BPP]
[CV(GEA)]
[CV(GEA)]
[GEA] 		[3]
NrdR-Zn2+ repressor nrdHp nrdH , nrdI , nrdE , nrdF 2800603 2800618 -45.5 cgaccactatTTGCTATATATTGTGTggttgaatct [APIORCISFBSCS]
[BPP]
[CV(GEA)]
[CV(GEA)]
[GEA] 		[3]
IscR activator nrdHp nrdH , nrdI , nrdE , nrdF         [GEA] [1]

Evidence: [AIBSCS] Automated inference based on similarity to consensus sequences
[CV(GEA)] cross validation(GEA)
[GEA] Gene expression analysis
[APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.
[BPP] Binding of purified proteins
Reference(s): [1] Martin JE., et al., 2011
[2] Vassinova N., et al., 2000
[3] Torrents E., et al., 2007



Reference(s)    

 [1] Martin JE., Imlay JA., 2011, The alternative aerobic ribonucleotide reductase of Escherichia coli, NrdEF, is a manganese-dependent enzyme that enables cell replication during periods of iron starvation., Mol Microbiol 80(2):319-34

 [2] Vassinova N., Kozyrev D., 2000, A method for direct cloning of fur-regulated genes: identification of seven new fur-regulated loci in Escherichia coli., Microbiology 146 Pt 12:3171-3182

 [3] Torrents E., Grinberg I., Gorovitz-Harris B., Lundstrom H., Borovok I., Aharonowitz Y., Sjoberg BM., Cohen G., 2007, NrdR controls differential expression of the Escherichia coli ribonucleotide reductase genes., J Bacteriol 189(14):5012-21

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