RegulonDB RegulonDB 10.8: Regulon Form
   
   


ArgR,CRP regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP , CRP-cAMP
Coregulator(s): AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BtsR, CRP, CRP-Sxy, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FucR, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsAB, RcsB, RcsB-BglJ, RhaR, RhaS, Rob, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YiaJ, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
ArgR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional dual regulator ArgR, XerA
Gene name(s): argR
Functional conformation(s): ArgR , ArgR-L-arginine
Coregulator(s): AdiY, ArgR, CRP, DksA-ppGpp, FNR, Fur, GadE, H-NS, HdfR, IHF, Lrp, Nac, NtrC, PhoP, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY ArgR,CRP Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
ArgR repressor CRP activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CRP-cAMP activator argGp argG 3318384 3318405 -167.5 ctgcaggcatTATAGTGATCCACGCCACATTTtgtcaacgtt [BPP]
[CV(SM)]
[GEA]
[SM]
[1]
ArgR-L-arginine repressor argGp argG 3318428 3318445 -125.5 ttgctaatcaTGTGAATGAATATCCAGTtcactttcat [AIBSCS]
[APIORCISFBSCS]
[BPP]
[CV(GEA)]
[CV(GEA)]
[GEA]
[2]
[3]
[1]
[4]
ArgR-L-arginine repressor argGp argG 3318547 3318564 -6.5 ataaaagatgATTAAATGAAAACTCATTtattttgcat [AIBSCS]
[APIORCISFBSCS]
[BPP]
[CV(GEA)]
[CV(GEA)]
[GEA]
[2]
[3]
[1]
[4]
ArgR-L-arginine repressor argGp argG 3318568 3318585 15.5 actcatttatTTTGCATAAAAATTCAGTgagagcggaa [AIBSCS]
[APIORCISFBSCS]
[BPP]
[CV(GEA)]
[CV(GEA)]
[GEA]
[2]
[3]
[1]
[4]
ArgR repressor CRP repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
ArgR-L-arginine repressor metYp2 pnp , rpsO , truB , rbfA , infB , nusA , rimP , metY 3318568 3318585 -201.5 ttccgctctcACTGAATTTTTATGCAAAataaatgagt [AIBSCS]
[APIORCISFBSCS]
[BPP]
[CV(GEA)]
[CV(GEA)]
[GEA]
[2]
[3]
[1]
[4]
ArgR-L-arginine repressor metYp2 pnp , rpsO , truB , rbfA , infB , nusA , rimP , metY 3318547 3318564 -180.5 atgcaaaataAATGAGTTTTCATTTAATcatcttttat [AIBSCS]
[APIORCISFBSCS]
[BPP]
[CV(GEA)]
[CV(GEA)]
[GEA]
[2]
[3]
[1]
[4]
ArgR-L-arginine repressor metYp2 pnp , rpsO , truB , rbfA , infB , nusA , rimP , metY 3318428 3318445 -61.5 atgaaagtgaACTGGATATTCATTCACAtgattagcaa [AIBSCS]
[APIORCISFBSCS]
[BPP]
[CV(GEA)]
[CV(GEA)]
[GEA]
[2]
[3]
[1]
[4]
CRP-cAMP repressor metYp2 pnp , rpsO , truB , rbfA , infB , nusA , rimP , metY 3318384 3318405 -19.5 aacgttgacaAAATGTGGCGTGGATCACTATAatgcctgcag [BPP]
[CV(SM)]
[GEA]
[SM]
[1]

Evidence: [BPP] Binding of purified proteins
[CV(SM)] cross validation(SM)
[GEA] Gene expression analysis
[SM] Site mutation
[AIBSCS] Automated inference based on similarity to consensus sequences
[APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.
[CV(GEA)] cross validation(GEA)
Reference(s): [1] Krin E., et al., 2003
[2] Caldara M., et al., 2006
[3] Charlier D., et al., 1992
[4] Makarova KS., et al., 2001



Reference(s)    

 [1] Krin E., Laurent-Winter C., Bertin PN., Danchin A., Kolb A., 2003, Transcription regulation coupling of the divergent argG and metY promoters in Escherichia coli K-12., J Bacteriol 185(10):3139-46

 [2] Caldara M., Charlier D., Cunin R., 2006, The arginine regulon of Escherichia coli: whole-system transcriptome analysis discovers new genes and provides an integrated view of arginine regulation., Microbiology 152(Pt 11):3343-54

 [3] Charlier D., Roovers M., Van Vliet F., Boyen A., Cunin R., Nakamura Y., Glansdorff N., Pierard A., 1992, Arginine regulon of Escherichia coli K-12. A study of repressor-operator interactions and of in vitro binding affinities versus in vivo repression., J Mol Biol 226(2):367-86

 [4] Makarova KS., Mironov AA., Gelfand MS., 2001, Conservation of the binding site for the arginine repressor in all bacterial lineages., Genome Biol 2(4):RESEARCH0013


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