RegulonDB RegulonDB 10.8: Regulon Form
   
   


ArgR,PhoP regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
PhoP Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional dual regulator PhoP, PhoP response regulator
Gene name(s): phoP
Functional conformation(s): PhoP , PhoP-Phosphorylated
Coregulator(s): AcrR, ArcA, ArgR, BasR, CRP, CysB, EnvR, EvgA, FNR, FadR, FliZ, GadE, GadW, GadX, H-NS, HypT, Lrp, MalT, MarA, MetJ, MprA, NagC, NarL, NarP, NtrC, OmpR, PdhR, PhoP, PurR, RbsR, RcsB, Rob, RutR, SdiA, SlyA, SoxR, SoxS, TorR, UvrY, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
ArgR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional dual regulator ArgR, XerA
Gene name(s): argR
Functional conformation(s): ArgR , ArgR-L-arginine
Coregulator(s): AdiY, ArgR, CRP, DksA-ppGpp, FNR, Fur, GadE, H-NS, HdfR, IHF, Lrp, Nac, NtrC, PhoP, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY ArgR,PhoP Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
ArgR repressor PhoP repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
ArgR-L-arginine repressor argDp argD 3490232 3490249 -19.5 attgccatttAGTGATTTTTTATGCATAttttgtggtt [AIBSCS]
[APIORCISFBSCS]
[BPP]
[CV(GEA)]
[CV(GEA)]
[GEA]
[1]
[2]
[3]
PhoP-Phosphorylated repressor argDp argD 3490203 3490219 11.0 ttgtggttatAATTTCACATTTGTTTAtgcgtaacag [AIBSCS]
[CV(GEA)]
[GEA]
[4]
ArgR-L-arginine repressor argDp argD 3490211 3490228 2.5 atgcatatttTGTGGTTATAATTTCACAtttgtttatg [AIBSCS]
[BPP]
[1]
[2]
[3]

Evidence: [AIBSCS] Automated inference based on similarity to consensus sequences
[APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.
[BPP] Binding of purified proteins
[CV(GEA)] cross validation(GEA)
[GEA] Gene expression analysis
Reference(s): [1] Caldara M., et al., 2006
[2] Charlier D., et al., 1992
[3] Makarova KS., et al., 2001
[4] Monsieurs P., et al., 2005



Reference(s)    

 [1] Caldara M., Charlier D., Cunin R., 2006, The arginine regulon of Escherichia coli: whole-system transcriptome analysis discovers new genes and provides an integrated view of arginine regulation., Microbiology 152(Pt 11):3343-54

 [2] Charlier D., Roovers M., Van Vliet F., Boyen A., Cunin R., Nakamura Y., Glansdorff N., Pierard A., 1992, Arginine regulon of Escherichia coli K-12. A study of repressor-operator interactions and of in vitro binding affinities versus in vivo repression., J Mol Biol 226(2):367-86

 [3] Makarova KS., Mironov AA., Gelfand MS., 2001, Conservation of the binding site for the arginine repressor in all bacterial lineages., Genome Biol 2(4):RESEARCH0013

 [4] Monsieurs P., De Keersmaecker S., Navarre WW., Bader MW., De Smet F., McClelland M., Fang FC., De Moor B., Vanderleyden J., Marchal K., 2005, Comparison of the PhoPQ regulon in Escherichia coli and Salmonella typhimurium., J Mol Evol 60(4):462-74


RegulonDB