RegulonDB RegulonDB 10.8: Regulon Form
   
   


CRP,CytR,Nac regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP , CRP-cAMP
Coregulator(s): AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BtsR, CRP, CRP-Sxy, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FucR, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsAB, RcsB, RcsB-BglJ, RhaR, RhaS, Rob, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YiaJ, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
Nac Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator Nac
Gene name(s): nac
Functional conformation(s): Nac
Coregulator(s): AdiY, ArgP, ArgR, AsnC, CRP, CytR, FNR, Fur, GadE, HdfR, IHF, Lrp, Nac, NsrR, NtrC, PhoB, PurR, QseB
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
CytR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional repressor CytR
Gene name(s): cytR
Functional conformation(s): CytR-cytidine , CytR
Coregulator(s): CRP, CytR, DeoR, DnaA, Fis, ModE, Nac, NsrR
Summary: TF Summary ...[more]

REGULATION EXERTED BY CRP,CytR,Nac Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CRP activator CytR repressor Nac activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CRP-cAMP activator nupCp nupC 2512909 2512930 -89.5 aacatagcagAAATGTATGACAGATCACTATTtttgaagcct [APIORCISFBSCS]
[CV(GEA/ROMA)]
[GEA]
[1]
[2]
CRP-cAMP activator nupCp nupC 2512958 2512980 -40.5 gacgtcattaTAGTGTGTGTCAGATCTCGTTTTccttaaccat [AIBSCS]
[APIORCISFBSCS]
[CV(GEA/ROMA)]
[GEA]
[1]
[3]
[4]
[2]
CytR repressor nupCp nupC         [TAS] [1]
Nac activator nupCp nupC         [GEA] [5]

Evidence: [APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.
[CV(GEA/ROMA)] cross validation(GEA/ROMA)
[GEA] Gene expression analysis
[AIBSCS] Automated inference based on similarity to consensus sequences
[TAS] Traceable author statement
Reference(s): [1] Craig JE., et al., 1994
[2] Zheng D., et al., 2004
[3] Tsai MJ., et al., 2018
[4] Valentin-Hansen P., et al., 1991
[5] Zimmer DP., et al., 2000



Reference(s)    

 [1] Craig JE., Zhang Y., Gallagher MP., 1994, Cloning of the nupC gene of Escherichia coli encoding a nucleoside transport system, and identification of an adjacent insertion element, IS 186., Mol Microbiol 11(6):1159-68

 [2] Zheng D., Constantinidou C., Hobman JL., Minchin SD., 2004, Identification of the CRP regulon using in vitro and in vivo transcriptional profiling., Nucleic Acids Res 32(19):5874-93

 [3] Tsai MJ., Wang JR., Yang CD., Kao KC., Huang WL., Huang HY., Tseng CP., Huang HD., Ho SY., 2018, PredCRP: predicting and analysing the regulatory roles of CRP from its binding sites in Escherichia coli., Sci Rep 8(1):951

 [4] Valentin-Hansen P., Holst B., Sogaard-Andersen L., Martinussen J., Nesvera J., Douthwaite SR., 1991, Design of cAMP-CRP-activated promoters in Escherichia coli., Mol Microbiol 5(2):433-7

 [5] Zimmer DP., Soupene E., Lee HL., Wendisch VF., Khodursky AB., Peter BJ., Bender RA., Kustu S., 2000, Nitrogen regulatory protein C-controlled genes of Escherichia coli: scavenging as a defense against nitrogen limitation., Proc Natl Acad Sci U S A 97(26):14674-9


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