RegulonDB

TRANSCRIPTION FACTOR:

Name:

DnaA	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Sensing Class

Using internal synthesized signals

Synonym(s):

chromosomal replication initiator protein DnaA, chromosomal replication initiator protein/DNA-binding transcriptional dual regulator DnaA

Gene name(s):

dnaA

Functional conformation(s):

DnaA , DnaA-ATP

Coregulator(s):

ArcA, ArgP, CRP, CytR, DnaA, FNR, Fis, H-NS, LexA, MarA, NrdR, PurR, Rob, SoxS, ppGpp

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

LexA	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Sensing Class

Using internal synthesized signals

Synonym(s):

DNA-binding transcriptional repressor LexA, ExrA, Spr, Tsl, UmuA

Gene name(s):

lexA

Functional conformation(s):

LexA

Coregulator(s):

ArcA, CRP, DinJ-YafQ, DnaA, LexA, NagC, RcdA, RcsB-BglJ, ppGpp

Summary:

TF Summary ...[more]

REGULATION EXERTED BY DnaA,LexA

Info M3D | Colombos

KNOWN BINDING SITES (The central relative position is relative to the promoter +1)
DnaA repressor LexA repressor
Transcription Factor		Regulated		Binding Sites				Evidence	References
Functional conformation	Function	Promoter	Gene(s)	LeftPos	RigthPos	Central Rel-Pos	Sequence
LexA	repressor	recNp	recN	2751727	2751746	-22.5	ccagcctcttTACTGTATATAAAACCAGTTtatactgtac	[AIBSCS] [BPP] [CV(GEA)] [CV(GEA)] [GEA]	[1] [2]
LexA	repressor	recNp	recN	2751749	2751768	-0.5	aaccagtttaTACTGTACACAATAACAGTAatggtttttc	[AIBSCS] [BPP] [CV(GEA)] [CV(GEA)] [GEA]	[1] [2]
LexA	repressor	uvrBp3	uvrB	813120	813136	-24.5	tccactattcCTGTGGATAACCATGTGtattagagtt	[BPP] [CV(GEA)] [CV(GEA)] [CV(GEA/SM)] [CV(SM)] [GEA] [ICA] [SM]	[2]
DnaA-ATP	repressor	recNp	recN	2751751	2751759	-4.0	ccagtttataCTGTACACAataacagtaa	[CV(GEA)] [GEA] [ICA]	[2]
DnaA-ATP	repressor	recNp	recN	2751730	2751738	-25.0	gcctctttacTGTATATAAaaccagttta	[CV(GEA)] [GEA] [ICA]	[2]
DnaA-ATP	repressor	uvrBp2	uvrB	813330	813338	-128.0	gccgttgcttTGGGGATAAcccggtaagg	[BPP] [CV(GEA)] [CV(GEA)] [GEA] [ICA]	[2]
LexA	repressor	uvrBp2	uvrB	813234	813250	-220.5	tattttttaaCTGGTTAGATAAATGCAatggcagtca	[BPP] [CV(GEA)] [CV(GEA)] [GEA] [ICA]	[2]
DnaA-ATP	repressor	uvrBp3	uvrB	813133	813141	-15.0	tggataaccaTGTGTATTAgagttagaaa	[BPP] [CV(GEA)] [CV(GEA)] [GEA] [ICA]	[2]
LexA	repressor	uvrBp2	uvrB	813287	813303	-167.5	tgccataaaaCTGTCATCACTCATCTTgacaaatgtt	[BPP] [CV(GEA)] [CV(GEA)] [GEA] [ICA]	[2]
DnaA-ATP	repressor	uvrBp2	uvrB	813442	813450	-16.0	aactgtttttTTATCCAGTataatttgtt	[BPP] [CV(GEA)] [CV(GEA)] [GEA] [ICA]	[2]
DnaA-ATP	repressor	uvrBp2	uvrB	813310	813318	-148.0	tcttgacaaaTGTTAAAAAagccgttgct	[BPP] [CV(GEA)] [CV(GEA)] [GEA] [ICA]	[2]
LexA	repressor	uvrBp2	uvrB	813434	813450	-20.5	tggtgatgaaCTGTTTTTTTATCCAGTataatttgtt	[APIORCISFBSCS] [BPP] [CV(GEA)] [CV(GEA)] [CV(GEA/SM)] [CV(SM)] [GEA] [ICA] [SM]	[3] [4] [2]
DnaA-ATP	repressor	uvrBp2	uvrB	813377	813385	-81.0	acagagtaaaTTTTGCTCAtgattgacag	[BPP] [CV(GEA)] [CV(GEA)] [GEA] [ICA]	[2]
DnaA-ATP	repressor	uvrBp3	uvrB	813121	813129	-27.0	ccactattccTGTGGATAAccatgtgtat	[BPP] [CV(GEA)] [CV(GEA)] [CV(GEA/SM)] [CV(SM)] [GEA] [ICA] [SM]	[2]
DnaA-ATP	repressor	uvrBp3	uvrB	813107	813115	-41.0	ctggagacagTTATCCACTattcctgtgg	[BPP] [CV(GEA)] [CV(GEA)] [GEA] [ICA]	[2]

Evidence:

[AIBSCS] Automated inference based on similarity to consensus sequences
[BPP] Binding of purified proteins
[CV(GEA)] cross validation(GEA)
[GEA] Gene expression analysis
[CV(GEA/SM)] cross validation(GEA/SM)
[CV(SM)] cross validation(SM)
[ICA] Inferred by computational analysis
[SM] Site mutation
[APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.

Reference(s):

[1] Rostas K., et al., 1987
[2] Wurihan., et al., 2018
[3] Nissenson RA., et al., 1985
[4] Sancar GB., et al., 1982

Reference(s)
[1] Rostas K., Morton SJ., Picksley SM., Lloyd RG., 1987, Nucleotide sequence and LexA regulation of the Escherichia coli recN gene., Nucleic Acids Res 15(13):5041-9
[2] Wurihan., Gezi., Brambilla E., Wang S., Sun H., Fan L., Shi Y., Sclavi B., Morigen., 2018, DnaA and LexA Proteins Regulate Transcription of the uvrB Gene in Escherichia coli: The Role of DnaA in the Control of the SOS Regulon., Front Microbiol 9:1212
[3] Nissenson RA., Strewler GJ., Williams RD., Leung SC., 1985, Activation of the parathyroid hormone receptor-adenylate cyclase system in osteosarcoma cells by a human renal carcinoma factor., Cancer Res 45(11 Pt 1):5358-63
[4] Sancar GB., Sancar A., Little JW., Rupp WD., 1982, The uvrB gene of Escherichia coli has both lexA-repressed and lexA-independent promoters., Cell 28(3):523-30