RegulonDB

TRANSCRIPTION FACTOR:

Name:

FNR	Weight Matrix Tractordb tool

Connectivity class

Global Regulator

Sensing Class

Using internal synthesized signals

Synonym(s):

DNA-binding transcriptional dual regulator FNR, NirA, NirR, OssA, OxrA

Gene name(s):

fnr

Functional conformation(s):

FNR-[4Fe-4S]²⁺ reduced , FNR-[2Fe-2S]²⁺ oxidized , FNR

Coregulator(s):

AcrR, AdiY, ArcA, ArgP, ArgR, BtsR, CRP, CadC, CaiF, Cbl, CdaR, Cra, CueR, CusR, CysB, DcuR, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, ExuR, FNR, FhlA, Fis, FlhDC, Fur, GadE, GadE-RcsB, GadW, GadX, GcvA, GlpR, H-NS, HdfR, HprR, HyfR, HypT, IHF, LeuO, Lrp, MalT, MarA, MetR, MlrA, ModE, Nac, NagC, NarL, NarP, NfeR, NikR, NorR, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PhoB, PhoP, PurR, PuuR, RcsB, Rob, RstA, RutR, SlyA, SoxR, SoxS, TdcA, TdcR, TorR, YeiL, ppGpp

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

Nac	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Synonym(s):

DNA-binding transcriptional dual regulator Nac

Gene name(s):

nac

Functional conformation(s):

Nac

Coregulator(s):

AdiY, ArgP, ArgR, AsnC, CRP, CytR, FNR, Fur, GadE, HdfR, IHF, Lrp, Nac, NsrR, NtrC, PhoB, PurR, QseB

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

NtrC	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Sensing Class

Using internal synthesized signals

Synonym(s):

DNA-binding transcriptional dual regulator NtrC, GlnG, GlnT, NtrC response regulator

Gene name(s):

glnG

Functional conformation(s):

NtrC-P^asp

Coregulator(s):

ArcA, ArgR, CRP, CysB, FNR, Fis, Fur, GadX, GlrR, IHF, Nac, NtrC, PhoP, RcsB, RutR, ppGpp

TRANSCRIPTION FACTOR:

Info

Name:

Fur	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Sensing Class

External sensing using transported metabolites

Synonym(s):

DNA-binding transcriptional dual regulator Fur

Gene name(s):

fur

Functional conformation(s):

Fur-Mn²⁺ , Fur , Fur-Fe²⁺

Coregulator(s):

AcrR, AdiY, ArcA, ArgP, ArgR, CRP, CdaR, CpxR, Cra, CusR, EnvY, FNR, Fis, FliZ, Fur, GadE, GadX, H-NS, HdfR, HprR, HypT, IHF, IscR, LrhA, Lrp, MarA, MatA, MetR, MntR, ModE, MqsA, Nac, NagC, NarL, NfeR, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PhoB, PurR, QseB, RcnR, RcsAB, Rob, RstA, RutR, SlyA, SoxR, SoxS, YjjQ, Zur, ppGpp

Summary:

TF Summary ...[more]

REGULATION EXERTED BY FNR,Fur,Nac,NtrC

Info M3D | Colombos

KNOWN BINDING SITES (The central relative position is relative to the promoter +1)
FNR repressor Fur repressor Nac repressor NtrC activator
Transcription Factor		Regulated		Binding Sites				Evidence	References
Functional conformation	Function	Promoter	Gene(s)	LeftPos	RigthPos	Central Rel-Pos	Sequence
NtrC-P^asp	activator	nacp	nac	2062122	2062138	-152.0	tattgggtaaTGAACCATCGTGGTGCAtaccctcctt	[APIORCISFBSCS]	[1]
Nac	repressor	nacp	nac	2062046	2062060	-75.0	tgacgaatctATCATAATCTCTTATttgacagttg	[APIORCISFBSCS] [BPP] [CV(CHIP-SV/GEA/ROMA)] [CV(GEA/ROMA)] [GEA]	[1]
Fur-Fe²⁺	repressor	nacp	nac					[GEA]	[2]
FNR	repressor	nacp	nac					[GEA]	[2]

Evidence:	[APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence. [BPP] Binding of purified proteins [CV(CHIP-SV/GEA/ROMA)] cross validation(CHIP-SV/GEA/ROMA) [CV(GEA/ROMA)] cross validation(GEA/ROMA) [GEA] Gene expression analysis
Reference(s):	[1] Muse WB., et al., 1998 [2] Kumar R., et al., 2011

Reference(s)
[1] Muse WB., Bender RA., 1998, The nac (nitrogen assimilation control) gene from Escherichia coli., J Bacteriol 180(5):1166-73
[2] Kumar R., Shimizu K., 2011, Transcriptional regulation of main metabolic pathways of cyoA, cydB, fnr, and fur gene knockout Escherichia coli in C-limited and N-limited aerobic continuous cultures., Microb Cell Fact 10:3