RegulonDB RegulonDB 10.8: Regulon Form
   
   


PhoP,PurR,RbsR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
PhoP Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional dual regulator PhoP, PhoP response regulator
Gene name(s): phoP
Functional conformation(s): PhoP , PhoP-Phosphorylated
Coregulator(s): AcrR, ArcA, ArgR, BasR, CRP, CysB, EnvR, EvgA, FNR, FadR, FliZ, GadE, GadW, GadX, H-NS, HypT, Lrp, MalT, MarA, MetJ, MprA, NagC, NarL, NarP, NtrC, OmpR, PdhR, PhoP, PurR, RbsR, RcsB, Rob, RutR, SdiA, SlyA, SoxR, SoxS, TorR, UvrY, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
PurR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional repressor PurR
Gene name(s): purR
Functional conformation(s): PurR , PurR-Guanine , PurR-hypoxanthine
Coregulator(s): CRP, DnaA, FNR, Fis, Fur, GadE, GcvA, IHF, Lrp, MarA, MetR, Nac, PepA, PhoP, PurR, RbsR, RutR
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
RbsR      Tractordb tool
Connectivity class Local Regulator
Sensing Class External sensing using transported metabolites
Synonym(s): DNA-binding transcriptional dual regulator RbsR, regulator for rbs operon
Gene name(s): rbsR
Functional conformation(s): RbsR , RbsR-D-ribose
Coregulator(s): CRP, PhoP, PurR, RbsR
Summary: TF Summary ...[more]

REGULATION EXERTED BY PhoP,PurR,RbsR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
PhoP activator PurR repressor RbsR repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
PhoP-Phosphorylated activator purHp purD , purH 4208098 4208114 -479.0 taaacttcgtAATGAATTACGTGTTCActcttgagac [AIBSCS]
[CV(GEA)]
[GEA]
[1]
PurR-hypoxanthine repressor purHp purD , purH 4207640 4207655 -20.5 cgcgagcgttGCGCAAACGTTTTCGTtacaatgcgg [AIBSCS]
[APIORCISFBSCS]
[BPP]
[CV(GEA)]
[CV(GEA)]
[GEA]
[2]
[3]
RbsR repressor purHp purD , purH 4207638 4207657 -20.5 ttcgcgagcgTTGCGCAAACGTTTTCGTTAcaatgcgggc [AIBSCS]
[BPP]
[CV(GEA)]
[CV(GEA)]
[GEA]
[4]

Evidence: [AIBSCS] Automated inference based on similarity to consensus sequences
[CV(GEA)] cross validation(GEA)
[GEA] Gene expression analysis
[APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.
[BPP] Binding of purified proteins
Reference(s): [1] Monsieurs P., et al., 2005
[2] Cho BK., et al., 2011
[3] He B., et al., 1990
[4] Shimada T., et al., 2013



Reference(s)    

 [1] Monsieurs P., De Keersmaecker S., Navarre WW., Bader MW., De Smet F., McClelland M., Fang FC., De Moor B., Vanderleyden J., Marchal K., 2005, Comparison of the PhoPQ regulon in Escherichia coli and Salmonella typhimurium., J Mol Evol 60(4):462-74

 [2] Cho BK., Federowicz SA., Embree M., Park YS., Kim D., Palsson BO., 2011, The PurR regulon in Escherichia coli K-12 MG1655., Nucleic Acids Res 39(15):6456-64

 [3] He B., Shiau A., Choi KY., Zalkin H., Smith JM., 1990, Genes of the Escherichia coli pur regulon are negatively controlled by a repressor-operator interaction., J Bacteriol 172(8):4555-62

 [4] Shimada T., Kori A., Ishihama A., 2013, Involvement of the ribose operon repressor RbsR in regulation of purine nucleotide synthesis in Escherichia coli., FEMS Microbiol Lett 344(2):159-65


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