RegulonDB RegulonDB 10.8: Regulon Form
   
   


ArcA,LexA regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
ArcA Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class External-Two-component systems
Synonym(s): ArcA response regulator, CpxC, DNA-binding transcriptional dual regulator ArcA, Dye, FexA, Msp, Seg, SfrA, dye resistance protein
Gene name(s): arcA
Functional conformation(s): ArcA , ArcA-Phosphorylated
Coregulator(s): AdiY, AppY, ArcA, BetI, BtsR, CRP, CadC, CaiF, Cra, CusR, CysB, DcuR, DksA-ppGpp, DnaA, DpiA, FNR, FadR, Fis, FlhDC, Fur, GadE, GadE-RcsB, GadW, GadX, GatR, GlcC, GlpR, H-NS, HipB, HprR, HypT, IHF, IclR, IscR, LexA, LldR, Lrp, MarA, McbR, Mlc, ModE, MqsA, NarL, NarP, NsrR, NtrC, OmpR, PdhR, PhoP, PuuR, RcdA, RcsB, RhaS, Rob, RutR, SdiA, SlyA, SoxR, SoxS, TorR, TreR, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
LexA Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional repressor LexA, ExrA, Spr, Tsl, UmuA
Gene name(s): lexA
Functional conformation(s): LexA
Coregulator(s): ArcA, CRP, DinJ-YafQ, DnaA, LexA, NagC, RcdA, RcsB-BglJ, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY ArcA,LexA Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
ArcA repressor LexA repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
ArcA-Phosphorylated repressor ssbp3 ssb 4274077 4274091 74.5 aatggtacaaTCGCGCGTTTACACTtattcagaac [APIORCISFBSCS]
[BPP]
[CV(GEA)]
[CV(GEA)]
[GEA]
[1]
ArcA-Phosphorylated repressor ssbp3 ssb 4274034 4274048 31.5 tttcccggaaCCGAGGTCACAACATagtaaaagcg [APIORCISFBSCS]
[BPP]
[CV(GEA)]
[CV(GEA)]
[GEA]
[1]
ArcA-Phosphorylated repressor ssbp3 ssb 4273994 4274008 -9.5 attacccggaGTGTTGTGTAACAATgtctggccag [APIORCISFBSCS]
[BPP]
[CV(GEA)]
[CV(GEA)]
[GEA]
[1]
ArcA-Phosphorylated repressor ssbp3 ssb 4273931 4273945 -72.5 ggcgatcacaAACGGTTAATTATGAcacaaattga [APIORCISFBSCS]
[BPP]
[CV(GEA)]
[CV(GEA)]
[GEA]
[1]
LexA repressor ssbp3 ssb 4273955 4273974 -46.5 acacaaattgACCTGAATGAATATACAGTAttggaatgca [APIORCISFBSCS]
[BCE]
[2]
[3]
ArcA-Phosphorylated repressor uvrAp uvrA 4274077 4274091 -148.5 gttctgaataAGTGTAAACGCGCGAttgtaccatt [APIORCISFBSCS]
[BPP]
[CV(GEA)]
[CV(GEA)]
[GEA]
[1]
ArcA-Phosphorylated repressor uvrAp uvrA 4274034 4274048 -105.5 cgcttttactATGTTGTGACCTCGGttccgggaaa [APIORCISFBSCS]
[BPP]
[CV(GEA)]
[CV(GEA)]
[GEA]
[1]
ArcA-Phosphorylated repressor uvrAp uvrA 4273994 4274008 -65.5 ctggccagacATTGTTACACAACACtccgggtaat [APIORCISFBSCS]
[BPP]
[CV(GEA)]
[CV(GEA)]
[GEA]
[1]
ArcA-Phosphorylated repressor uvrAp uvrA 4273931 4273945 -2.5 tcaatttgtgTCATAATTAACCGTTtgtgatcgcc [APIORCISFBSCS]
[BPP]
[CV(GEA)]
[CV(GEA)]
[GEA]
[1]
LexA repressor uvrAp uvrA 4273955 4273974 -28.5 tgcattccaaTACTGTATATTCATTCAGGTcaatttgtgt [APIORCISFBSCS]
[BCE]
[2]
[3]

Evidence: [APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.
[BPP] Binding of purified proteins
[CV(GEA)] cross validation(GEA)
[GEA] Gene expression analysis
[BCE] Binding of cellular extracts
Reference(s): [1] Ogasawara H., et al., 2005
[2] Brandsma JA., et al., 1985
[3] Sancar A., et al., 1982



Reference(s)    

 [1] Ogasawara H., Teramoto J., Yamamoto S., Hirao K., Yamamoto K., Ishihama A., Utsumi R., 2005, Negative regulation of DNA repair gene (uvrA) expression by ArcA/ArcB two-component system in Escherichia coli., FEMS Microbiol Lett 251(2):243-9

 [2] Brandsma JA., Bosch D., de Ruyter M., van de Putte P., 1985, Analysis of the regulatory region of the ssb gene of Escherichia coli., Nucleic Acids Res 13(14):5095-109

 [3] Sancar A., Sancar GB., Rupp WD., Little JW., Mount DW., 1982, LexA protein inhibits transcription of the E. coli uvrA gene in vitro., Nature 298(5869):96-8


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