RegulonDB

TRANSCRIPTION FACTOR:

Name:

FNR	Weight Matrix Tractordb tool

Connectivity class

Global Regulator

Sensing Class

Using internal synthesized signals

Synonym(s):

DNA-binding transcriptional dual regulator FNR, NirA, NirR, OssA, OxrA

Gene name(s):

fnr

Functional conformation(s):

FNR-[4Fe-4S]²⁺ reduced , FNR-[2Fe-2S]²⁺ oxidized , FNR

Coregulator(s):

AcrR, AdiY, ArcA, ArgP, ArgR, BtsR, CRP, CadC, CaiF, Cbl, CdaR, Cra, CueR, CusR, CysB, DcuR, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, ExuR, FNR, FhlA, Fis, FlhDC, Fur, GadE, GadE-RcsB, GadW, GadX, GcvA, GlpR, H-NS, HdfR, HprR, HyfR, HypT, IHF, LeuO, Lrp, MalT, MarA, MetR, MlrA, ModE, Nac, NagC, NarL, NarP, NfeR, NikR, NorR, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PhoB, PhoP, PurR, PuuR, RcsB, Rob, RstA, RutR, SlyA, SoxR, SoxS, TdcA, TdcR, TorR, YeiL, ppGpp

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

FhlA	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Sensing Class

Using internal synthesized signals

Synonym(s):

DNA-binding transcriptional activator FhlA, Fhl, formate hydrogen-lyase transcriptional activator for fdhF, hyc and hyp operons

Gene name(s):

fhlA

Functional conformation(s):

FhlA , FhlA-formate

Coregulator(s):

CRP, FNR, FhlA, FlhDC, HyfR, IHF, ModE, NarL, NarP, NsrR

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

NarL	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Sensing Class

External-Two-component systems

Synonym(s):

DNA-binding transcriptional dual regulator NarL, FrdR, NarR, nitrate/nitrite response regulator NarL

Gene name(s):

narL

Functional conformation(s):

NarL , NarL-Phosphorylated

Coregulator(s):

AppY, ArcA, CRP, Cra, DcuR, DpiA, EvgA, FNR, FhlA, Fis, FlhDC, Fur, H-NS, IHF, IscR, Lrp, ModE, NagC, NarL, NarP, NikR, NorR, NsrR, OxyR, PhoP, RcsB, RstA, SoxS, TorR, UvrY, YdeO

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

NarP	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Sensing Class

External-Two-component systems

Synonym(s):

DNA-binding transcriptional dual regulator NarP, nitrate/nitrite response regulator NarP

Gene name(s):

narP

Functional conformation(s):

NarP , NarP-Phosphorylated

Coregulator(s):

AppY, ArcA, CRP, Cra, EvgA, FNR, FhlA, Fis, FlhDC, H-NS, IHF, IscR, ModE, NagC, NarL, NarP, NorR, NsrR, OxyR, PhoP, RcsB, UvrY, YdeO

Summary:

TF Summary ...[more]

REGULATION EXERTED BY FNR,FhlA,NarL,NarP

Info M3D | Colombos

KNOWN BINDING SITES (The central relative position is relative to the promoter +1)
FNR activator FhlA activator NarL repressor NarP activator
Transcription Factor		Regulated		Binding Sites				Evidence	References
Functional conformation	Function	Promoter	Gene(s)	LeftPos	RigthPos	Central Rel-Pos	Sequence
FhlA-formate	activator	fdhFp	fdhF	4299530	4299543	-129.5	gcgtgatggcTGTCACGCGGTATTtcgtttcgtc	[APIORCISFBSCS] [BPP] [CV(GEA)] [CV(GEA)] [GEA]	[1] [2] [3] [4]
FhlA-formate	activator	fdhFp	fdhF	4299505	4299518	-104.5	cgtttcgtcaCGTCAAAACTGACGacagcctgtt	[APIORCISFBSCS] [BPP] [CV(GEA)] [CV(GEA)] [GEA]	[4]
FNR	activator	fdhFp	fdhF					[GEA]	[5]
NarP-Phosphorylated	activator	fdhFp	fdhF					[GEA]	[6]
NarL-Phosphorylated	repressor	fdhFp	fdhF					[BPP] [GEA]	[6]

Evidence:	[APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence. [BPP] Binding of purified proteins [CV(GEA)] cross validation(GEA) [GEA] Gene expression analysis
Reference(s):	[1] Birkmann A., et al., 1989 [2] Birkmann A., et al., 1987 [3] Schlensog V., et al., 1990 [4] Schlensog V., et al., 1994 [5] Salmon K., et al., 2003 [6] Wang H., et al., 2003

Reference(s)
[1] Birkmann A., Bock A., 1989, Characterization of a cis regulatory DNA element necessary for formate induction of the formate dehydrogenase gene (fdhF) of Escherichia coli., Mol Microbiol 3(2):187-95
[2] Birkmann A., Zinoni F., Sawers G., Bock A., 1987, Factors affecting transcriptional regulation of the formate-hydrogen-lyase pathway of Escherichia coli., Arch Microbiol 148(1):44-51
[3] Schlensog V., Bock A., 1990, Identification and sequence analysis of the gene encoding the transcriptional activator of the formate hydrogenlyase system of Escherichia coli., Mol Microbiol 4(8):1319-27
[4] Schlensog V., Lutz S., Bock A., 1994, Purification and DNA-binding properties of FHLA, the transcriptional activator of the formate hydrogenlyase system from Escherichia coli., J Biol Chem 269(30):19590-6
[5] Salmon K., Hung SP., Mekjian K., Baldi P., Hatfield GW., Gunsalus RP., 2003, Global gene expression profiling in Escherichia coli K12. The effects of oxygen availability and FNR., J Biol Chem 278(32):29837-55
[6] Wang H., Gunsalus RP., 2003, Coordinate regulation of the Escherichia coli formate dehydrogenase fdnGHI and fdhF genes in response to nitrate, nitrite, and formate: roles for NarL and NarP., J Bacteriol 185(17):5076-85