RegulonDB

TRANSCRIPTION FACTOR:

Name:

Cra	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Sensing Class

Using internal synthesized signals

Synonym(s):

DNA-binding transcriptional dual regulator Cra, FruC, FruR, Shl

Gene name(s):

cra

Functional conformation(s):

Cra-;-D-fructose 1,6-bisphosphate , Cra-β-D-fructose 1,6-bisphosphate , Cra-β-D-fructofuranose 1-phosphate , Cra

Coregulator(s):

AcrR, ArcA, BasR, BetI, BtsR, CRP, CpxR, Cra, CsgD, CusR, DcuR, DksA, FNR, Fis, FliZ, Fur, GadE, GlcC, GntR, H-NS, HprR, IHF, IclR, KdgR, Lrp, MarA, MarR, Mlc, MlrA, MqsA, NagC, NarL, NarP, OmpR, PdhR, PrpR, RcdA, RcsAB, Rob, RstA, SgrR, SoxS, TyrR, ppGpp

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

SgrR	Tractordb tool

Connectivity class

Local Regulator

Synonym(s):

DNA-binding transcriptional dual regulator SgrR, YabN

Gene name(s):

sgrR

Functional conformation(s):

SgrR

Coregulator(s):

Cra, DksA, SgrR, ppGpp

Summary:

TF Summary ...[more]

REGULATION EXERTED BY Cra,DksA,SgrR,ppGpp

Info M3D | Colombos

KNOWN BINDING SITES (The central relative position is relative to the promoter +1)
Cra repressor DksA activation SgrR activator ppGpp activation
Transcription Factor		Regulated		Binding Sites				Evidence	References
Functional conformation	Function	Promoter	Gene(s)	LeftPos	RigthPos	Central Rel-Pos	Sequence
SgrR	activator	sgrSp	sgrS , sgrT , setA	77297	77330	-53.5	gagcagatggCATAAAAGGGGAACTCCTGTGCAAAAGACAGCAAttttattttc	[APIORCISFBSCS] [BPP] [CV(GEA)] [CV(GEA)] [CV(GEA/SM)] [CV(SM)] [GEA] [SM]	[1] [2] [3]
Cra	repressor	sgrSp	sgrS , sgrT , setA	77026	77043	-332.5	tgcaccagttGATCGATACGATCCTGCTccagcaggtc	[AIBSCS] [CV(GEA)] [GEA]	[4]

Evidence:	[APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence. [BPP] Binding of purified proteins [CV(GEA)] cross validation(GEA) [CV(GEA/SM)] cross validation(GEA/SM) [CV(SM)] cross validation(SM) [GEA] Gene expression analysis [SM] Site mutation [AIBSCS] Automated inference based on similarity to consensus sequences
Reference(s):	[1] Sun Y., et al., 2011 [2] Vanderpool CK., et al., 2004 [3] Vanderpool CK., et al., 2007 [4] Shimada T., et al., 2011

Reference(s)
[1] Sun Y., Vanderpool CK., 2011, Regulation and function of Escherichia coli sugar efflux transporter A (SetA) during glucose-phosphate stress., J Bacteriol 193(1):143-53
[2] Vanderpool CK., Gottesman S., 2004, Involvement of a novel transcriptional activator and small RNA in post-transcriptional regulation of the glucose phosphoenolpyruvate phosphotransferase system., Mol Microbiol 54(4):1076-89
[3] Vanderpool CK., Gottesman S., 2007, The novel transcription factor SgrR coordinates the response to glucose-phosphate stress., J Bacteriol 189(6):2238-48
[4] Shimada T., Yamamoto K., Ishihama A., 2011, Novel members of the Cra regulon involved in carbon metabolism in Escherichia coli., J Bacteriol 193(3):649-59