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LexA,ppGpp regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
LexA Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional repressor LexA, ExrA, Spr, Tsl, UmuA
Gene name(s): lexA
Functional conformation(s): LexA
Coregulator(s): ArcA, CRP, DinJ-YafQ, DnaA, LexA, NagC, RcdA, RcsB-BglJ, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY LexA,ppGpp Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
LexA repressor ppGpp activation    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
LexA repressor ftsKp1 ftsK 933128 933147 -0.5 ttgattacacTCCTGTTAATCCATACAGCAacagtactgg [AIBSCS]
[BPP]
[CV(GEA)]
[CV(GEA)]
[GEA]
[1]
[2]
[3]

Evidence: [AIBSCS] Automated inference based on similarity to consensus sequences
[BPP] Binding of purified proteins
[CV(GEA)] cross validation(GEA)
[GEA] Gene expression analysis
Reference(s): [1] Dorazi R., et al., 2000
[2] Lewis LK., et al., 1994
[3] Lewis LK., et al., 1992



Reference(s)    

 [1] Dorazi R., Dewar SJ., 2000, The SOS promoter dinH is essential for ftsK transcription during cell division., Microbiology 146 ( Pt 11):2891-9

 [2] Lewis LK., Harlow GR., Gregg-Jolly LA., Mount DW., 1994, Identification of high affinity binding sites for LexA which define new DNA damage-inducible genes in Escherichia coli., J Mol Biol 241(4):507-23

 [3] Lewis LK., Jenkins ME., Mount DW., 1992, Isolation of DNA damage-inducible promoters in Escherichia coli: regulation of polB (dinA), dinG, and dinH by LexA repressor., J Bacteriol 174(10):3377-85


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