RegulonDB

TRANSCRIPTION FACTOR:

Name:

LexA	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Sensing Class

Using internal synthesized signals

Synonym(s):

DNA-binding transcriptional repressor LexA, ExrA, Spr, Tsl, UmuA

Gene name(s):

lexA

Functional conformation(s):

LexA

Coregulator(s):

ArcA, CRP, DinJ-YafQ, DnaA, LexA, NagC, RcdA, RcsB-BglJ, ppGpp

Summary:

TF Summary ...[more]

REGULATION EXERTED BY LexA,ppGpp

Info M3D | Colombos

KNOWN BINDING SITES (The central relative position is relative to the promoter +1)
LexA repressor ppGpp activation
Transcription Factor		Regulated		Binding Sites				Evidence	References
Functional conformation	Function	Promoter	Gene(s)	LeftPos	RigthPos	Central Rel-Pos	Sequence
LexA	repressor	ftsKp1	ftsK	933128	933147	-0.5	ttgattacacTCCTGTTAATCCATACAGCAacagtactgg	[AIBSCS] [BPP] [CV(GEA)] [CV(GEA)] [GEA]	[1] [2] [3]

Evidence:	[AIBSCS] Automated inference based on similarity to consensus sequences [BPP] Binding of purified proteins [CV(GEA)] cross validation(GEA) [GEA] Gene expression analysis
Reference(s):	[1] Dorazi R., et al., 2000 [2] Lewis LK., et al., 1994 [3] Lewis LK., et al., 1992

Reference(s)
[1] Dorazi R., Dewar SJ., 2000, The SOS promoter dinH is essential for ftsK transcription during cell division., Microbiology 146 ( Pt 11):2891-9
[2] Lewis LK., Harlow GR., Gregg-Jolly LA., Mount DW., 1994, Identification of high affinity binding sites for LexA which define new DNA damage-inducible genes in Escherichia coli., J Mol Biol 241(4):507-23
[3] Lewis LK., Jenkins ME., Mount DW., 1992, Isolation of DNA damage-inducible promoters in Escherichia coli: regulation of polB (dinA), dinG, and dinH by LexA repressor., J Bacteriol 174(10):3377-85