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DinJ-YafQ,LexA regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
LexA Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional repressor LexA, ExrA, Spr, Tsl, UmuA
Gene name(s): lexA
Functional conformation(s): LexA
Coregulator(s): ArcA, CRP, DinJ-YafQ, DnaA, LexA, NagC, RcdA, RcsB-BglJ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
DinJ-YafQ      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DinJ-YafQ antitoxin/toxin complex / DNA-binding transcriptional repressor, DinJ/Q
Gene name(s): yafQ, dinJ
Functional conformation(s): DinJ-YafQ
Coregulator(s): DinJ-YafQ, LexA
Summary: TF Summary ...[more]

REGULATION EXERTED BY DinJ-YafQ,LexA Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
DinJ-YafQ repressor LexA repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
LexA repressor dinJp yafQ , dinJ 246517 246536 89.5 ctacaattcaAGCTGAATAAATATACAGCAcaggagatac [AIBSCS]
[CV(GEA)]
[GEA] 		[1]
[2]
DinJ-YafQ repressor dinJp yafQ , dinJ 246519 246535 89.5 tacaattcaaGCTGAATAAATATACAGcacaggagat [APIORCISFBSCS]
[BPP]
[CV(SM)]
[SM] 		[3]
[2]

Evidence: [AIBSCS] Automated inference based on similarity to consensus sequences
[CV(GEA)] cross validation(GEA)
[GEA] Gene expression analysis
[APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.
[BPP] Binding of purified proteins
[CV(SM)] cross validation(SM)
[SM] Site mutation
Reference(s): [1] Lewis LK., et al., 1994
[2] Ruangprasert A., et al., 2014
[3] Prysak MH., et al., 2009



Reference(s)    

 [1] Lewis LK., Harlow GR., Gregg-Jolly LA., Mount DW., 1994, Identification of high affinity binding sites for LexA which define new DNA damage-inducible genes in Escherichia coli., J Mol Biol 241(4):507-23

 [2] Ruangprasert A., Maehigashi T., Miles SJ., Giridharan N., Liu JX., Dunham CM., 2014, Mechanisms of toxin inhibition and transcriptional repression by Escherichia coli DinJ-YafQ., J Biol Chem 289(30):20559-69

 [3] Prysak MH., Mozdzierz CJ., Cook AM., Zhu L., Zhang Y., Inouye M., Woychik NA., 2009, Bacterial toxin YafQ is an endoribonuclease that associates with the ribosome and blocks translation elongation through sequence-specific and frame-dependent mRNA cleavage., Mol Microbiol 71(5):1071-87

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