RegulonDB RegulonDB 10.9: Regulon Form
   
   


CRP,MetJ regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP-cAMP , CRP
Coregulator(s): AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BolA, BtsR, CRP, CRP-Sxy, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FucR, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsAB, RcsB, RcsB-BglJ, RhaR, RhaS, Rob, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YiaJ, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
MetJ Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): B3938, MetJ, MetJ-SAM
Gene name(s): metJ
Functional conformation(s): MetJ-S-adenosyl-L-methionine , MetJ-adenine , MetJ-MTA , MetJ
Coregulator(s): CRP, HypT, MetJ, MetR, OxyR, PhoP
Summary: TF Summary ...[more]

REGULATION EXERTED BY CRP,MetJ Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CRP repressor MetJ repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CRP-cAMP repressor metKp metK 3086506 3086527 -60.5 gtttttaacaGAATGAGACACGATTCAAAAAAAagtggaaata   [1]
MetJ-S-adenosyl-L-methionine repressor metKp metK 3086567 3086582 -2.5 aaatagccatCCAGATGTTAATCCATCcataccgatt   [2]
MetJ-S-adenosyl-L-methionine repressor metKp metK 3086555 3086570 -14.5 agaattgaccTAAAATAGCCATCCAGAtgttaatcca   [2]
MetJ-S-adenosyl-L-methionine repressor metKp2 metK 3086555 3086570 -14.5 agaattgaccTAAAATAGCCATCCAGAtgttaatcca   [2]
MetJ-S-adenosyl-L-methionine repressor metKp2 metK 3086567 3086582 -2.5 aaatagccatCCAGATGTTAATCCATCcataccgatt   [2]
CRP-cAMP repressor metKp2 metK 3086506 3086527 -60.5 gtttttaacaGAATGAGACACGATTCAAAAAAAagtggaaata   [1]

Reference(s): [1] Zheng D., et al., 2004
[2] Liu R., et al., 2001



Reference(s)    

 [1] Zheng D., Constantinidou C., Hobman JL., Minchin SD., 2004, Identification of the CRP regulon using in vitro and in vivo transcriptional profiling., Nucleic Acids Res 32(19):5874-93

 [2] Liu R., Blackwell TW., States DJ., 2001, Conformational model for binding site recognition by the E.coli MetJ transcription factor., Bioinformatics 17(7):622-33


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