RegulonDB RegulonDB 10.9: Regulon Form
   
   


ArcA,FadR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
ArcA Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class External-Two-component systems
Synonym(s): ArcA response regulator, CpxC, DNA-binding transcriptional dual regulator ArcA, Dye, FexA, Msp, Seg, SfrA, dye resistance protein
Gene name(s): arcA
Functional conformation(s): ArcA-phosphorylated , ArcA
Coregulator(s): AdiY, AppY, ArcA, BetI, BtsR, CRP, CadC, CaiF, Cra, CusR, CysB, DcuR, DksA-ppGpp, DnaA, DpiA, FNR, FadR, Fis, FlhDC, Fur, GadE, GadE-RcsB, GadW, GadX, GatR, GlcC, GlpR, H-NS, HipB, HprR, HypT, IHF, IclR, IscR, LexA, LldR, Lrp, MarA, McbR, Mlc, ModE, MqsA, NarL, NarP, NsrR, NtrC, OmpR, PdhR, PhoP, PuuR, RcdA, RcsB, RhaS, Rob, RutR, SdiA, SlyA, SoxR, SoxS, TorR, TreR, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
FadR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator FadR, Dec, Ole, OleR, ThdB
Gene name(s): fadR
Functional conformation(s): FadR-acyl-CoA , FadR
Coregulator(s): ArcA, CRP, DksA-ppGpp, FabR, FadR, Fis, HipB, IHF, IclR, OmpR, PhoP, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY ArcA,FadR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
ArcA repressor FadR repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
ArcA-phosphorylated repressor fadEp fadE 243385 243399 15.0 agctttgttgTAATTATATTGTAAACatattgctaa [EME] [1]
[2]
FadR repressor fadEp fadE 243325 243341 74.0 catatcatcaCAAGTGGTCAGACCTCCTacaagtaagg   [3]
ArcA-phosphorylated repressor fadIp fadJ , fadI 2460521 2460535 -17.0 cttggctaaaTGTAAAAAAATGGTTAagactatgat   [1]
FadR repressor fadIp fadJ , fadI 2460496 2460512 8.0 ttaagactatGATCAGGTCAGACCACTTtatttatttt   [4]

Evidence: [EME] Expression microarray evidence
Reference(s): [1] Cho BK., et al., 2006
[2] Federowicz S., et al., 2014
[3] Campbell JW., et al., 2002
[4] Campbell JW., et al., 2003



Reference(s)    

 [1] Cho BK., Knight EM., Palsson BO., 2006, Transcriptional regulation of the fad regulon genes of Escherichia coli by ArcA., Microbiology 152(Pt 8):2207-19

 [2] Federowicz S., Kim D., Ebrahim A., Lerman J., Nagarajan H., Cho BK., Zengler K., Palsson B., 2014, Determining the control circuitry of redox metabolism at the genome-scale., PLoS Genet 10(4):e1004264

 [3] Campbell JW., Cronan JE., 2002, The enigmatic Escherichia coli fadE gene is yafH., J Bacteriol 184(13):3759-64

 [4] Campbell JW., Morgan-Kiss RM., E Cronan J., 2003, A new Escherichia coli metabolic competency: growth on fatty acids by a novel anaerobic beta-oxidation pathway., Mol Microbiol 47(3):793-805


RegulonDB