RegulonDB RegulonDB 10.9: Regulon Form
   
   


DksA-ppGpp,FadR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
FadR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator FadR, Dec, Ole, OleR, ThdB
Gene name(s): fadR
Functional conformation(s): FadR-acyl-CoA , FadR
Coregulator(s): ArcA, CRP, DksA-ppGpp, FabR, FadR, Fis, HipB, IHF, IclR, OmpR, PhoP, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY DksA-ppGpp,FadR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
DksA-ppGpp inhibition FadR activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
FadR-acyl-CoA activator fadRp fadR 1234887 1234904 -10.0 gtagttagccCTCTGGTATGATGAGTCCaactttgttt   [1]
FadR activator fabHp fabH , fabD , fabG 1148470 1148486 -38.0 attcagtcacCTCAACCCCGACCAGTATaacggcgcct   [2]

Reference(s): [1] Zhang F., et al., 2012
[2] My L., et al., 2013



Reference(s)    

 [1] Zhang F., Ouellet M., Batth TS., Adams PD., Petzold CJ., Mukhopadhyay A., Keasling JD., 2012, Enhancing fatty acid production by the expression of the regulatory transcription factor FadR., Metab Eng 14(6):653-60

 [2] My L., Rekoske B., Lemke JJ., Viala JP., Gourse RL., Bouveret E., 2013, Transcription of the Escherichia coli Fatty Acid Synthesis Operon fabHDG Is Directly Activated by FadR and Inhibited by ppGpp., J Bacteriol 195(16):3784-95


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