RegulonDB RegulonDB 10.10: Regulon Form
   
   


GcvA regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
GcvA Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional dual regulator GcvA, positive regulator of gcv operon
Gene name(s): gcvA
Functional conformation(s): GcvA , GcvA-glycine , GcvA-Purine
Coregulator(s): CRP, FNR, GcvA, Lrp, PurR
Summary: TF Summary ...[more]

REGULATION EXERTED BY GcvA Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
GcvA activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
GcvA activator gcvBp gcvB 2942646 2942660 -43.0 aatctgagccATTATAAATTGTCCGttgagcttct [GEA]
[IC]
[1]
[2]
[3]
[4]
[5]
GcvA activator gcvBp gcvB 2942624 2942638 -65.0 tatgtaacctATTAGTTTTTTTAATctgagccatt [GEA] [1]
[2]
[3]
[4]
[5]
GcvA repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
GcvA repressor gcvAp gcvA 2942646 2942660 -14.0 agaagctcaaCGGACAATTTATAATggctcagatt [GEA]
[IC]
[1]
[2]
[3]
[4]
[5]
GcvA repressor gcvAp gcvA 2942624 2942638 9.0 aatggctcagATTAAAAAAACTAATaggttacata [GEA] [1]
[2]
[3]
[4]
[5]

Evidence: [GEA] Gene expression analysis
[IC] Inferred by curator
Reference(s): [1] Jourdan AD., et al., 1999
[2] Stauffer LT., et al., 2005
[3] Urbanowski ML., et al., 2000
[4] Wilson RL., et al., 1994
[5] Wilson RL., et al., 1995



Reference(s)    

 [1] Jourdan AD., Stauffer GV., 1999, Genetic analysis of the GcvA binding site in the gcvA control region., Microbiology 145 ( Pt 8):2153-62

 [2] Stauffer LT., Stauffer GV., 2005, GcvA interacts with both the alpha and sigma subunits of RNA polymerase to activate the Escherichia coli gcvB gene and the gcvTHP operon., FEMS Microbiol Lett 242(2):333-8

 [3] Urbanowski ML., Stauffer LT., Stauffer GV., 2000, The gcvB gene encodes a small untranslated RNA involved in expression of the dipeptide and oligopeptide transport systems in Escherichia coli., Mol Microbiol 37(4):856-68

 [4] Wilson RL., Stauffer GV., 1994, DNA sequence and characterization of GcvA, a LysR family regulatory protein for the Escherichia coli glycine cleavage enzyme system., J Bacteriol 176(10):2862-8

 [5] Wilson RL., Urbanowski ML., Stauffer GV., 1995, DNA binding sites of the LysR-type regulator GcvA in the gcv and gcvA control regions of Escherichia coli., J Bacteriol 177(17):4940-6


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