RegulonDB

TRANSCRIPTION FACTOR:

Name:

GcvA	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Sensing Class

Sensing external and internal signals

Synonym(s):

DNA-binding transcriptional dual regulator GcvA, positive regulator of gcv operon

Gene name(s):

gcvA

Functional conformation(s):

GcvA , GcvA-glycine , GcvA-Purine

Coregulator(s):

CRP, FNR, GcvA, Lrp, PurR

Summary:

TF Summary ...[more]

REGULATION EXERTED BY GcvA

Info M3D | Colombos

KNOWN BINDING SITES (The central relative position is relative to the promoter +1)
GcvA activator
Transcription Factor		Regulated		Binding Sites				Evidence	References
Functional conformation	Function	Promoter	Gene(s)	LeftPos	RigthPos	Central Rel-Pos	Sequence
GcvA	activator	gcvBp	gcvB	2942646	2942660	-43.0	aatctgagccATTATAAATTGTCCGttgagcttct	[GEA] [IC]	[1] [2] [3] [4] [5]
GcvA	activator	gcvBp	gcvB	2942624	2942638	-65.0	tatgtaacctATTAGTTTTTTTAATctgagccatt	[GEA]	[1] [2] [3] [4] [5]
GcvA repressor
Transcription Factor		Regulated		Binding Sites				Evidence	References
Functional conformation	Function	Promoter	Gene(s)	LeftPos	RigthPos	Central Rel-Pos	Sequence
GcvA	repressor	gcvAp	gcvA	2942646	2942660	-14.0	agaagctcaaCGGACAATTTATAATggctcagatt	[GEA] [IC]	[1] [2] [3] [4] [5]
GcvA	repressor	gcvAp	gcvA	2942624	2942638	9.0	aatggctcagATTAAAAAAACTAATaggttacata	[GEA]	[1] [2] [3] [4] [5]

Evidence:	[GEA] Gene expression analysis [IC] Inferred by curator
Reference(s):	[1] Jourdan AD., et al., 1999 [2] Stauffer LT., et al., 2005 [3] Urbanowski ML., et al., 2000 [4] Wilson RL., et al., 1994 [5] Wilson RL., et al., 1995

Reference(s)
[1] Jourdan AD., Stauffer GV., 1999, Genetic analysis of the GcvA binding site in the gcvA control region., Microbiology 145 ( Pt 8):2153-62
[2] Stauffer LT., Stauffer GV., 2005, GcvA interacts with both the alpha and sigma subunits of RNA polymerase to activate the Escherichia coli gcvB gene and the gcvTHP operon., FEMS Microbiol Lett 242(2):333-8
[3] Urbanowski ML., Stauffer LT., Stauffer GV., 2000, The gcvB gene encodes a small untranslated RNA involved in expression of the dipeptide and oligopeptide transport systems in Escherichia coli., Mol Microbiol 37(4):856-68
[4] Wilson RL., Stauffer GV., 1994, DNA sequence and characterization of GcvA, a LysR family regulatory protein for the Escherichia coli glycine cleavage enzyme system., J Bacteriol 176(10):2862-8
[5] Wilson RL., Urbanowski ML., Stauffer GV., 1995, DNA binding sites of the LysR-type regulator GcvA in the gcv and gcvA control regions of Escherichia coli., J Bacteriol 177(17):4940-6