RegulonDB

TRANSCRIPTION FACTOR:

Name:

MarA	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Synonym(s):

CfxB, DNA-binding transcriptional dual regulator MarA, InaR, NfxC, NorB, SoxQ

Gene name(s):

marA

Functional conformation(s):

MarA

Coregulator(s):

AcrR, ArcA, BasR, BluR, CRP, CpxR, Cra, DnaA, EnvR, FNR, Fis, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, H-NS, HU, IHF, LacI, Lrp, MarA, MarR, MprA, OmpR, OxyR, PhoP, PurR, PutA, RcsB, Rob, SoxR, SoxS, TorR, YdeO

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

GadE	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Synonym(s):

DNA-binding transcriptional activator GadE, YhiE, YhiT, acid-responsive regulator of gadA and gadBC

Gene name(s):

gadE

Functional conformation(s):

GadE

Coregulator(s):

AdiY, ArcA, ArgR, CRP, CadC, CpxR, Cra, CusR, EvgA, FNR, Fis, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, H-NS, HdfR, HprR, IHF, Lrp, MarA, MatA, Nac, NsrR, OmpR, PdhR, PhoB, PhoP, PurR, RcsAB, RcsB, Rob, RutR, TorR, YdeO, ppGpp

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

PurR	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Sensing Class

Using internal synthesized signals

Synonym(s):

DNA-binding transcriptional repressor PurR

Gene name(s):

purR

Functional conformation(s):

PurR-hypoxanthine , PurR-Guanine , PurR

Coregulator(s):

CRP, DnaA, FNR, Fis, Fur, GadE, GcvA, IHF, Lrp, MarA, MetR, Nac, PepA, PhoP, PurR, RbsR, RutR

Summary:

TF Summary ...[more]

REGULATION EXERTED BY GadE,MarA,PurR

Info M3D | Colombos

KNOWN BINDING SITES (The central relative position is relative to the promoter +1)
GadE activator MarA repressor PurR repressor
Transcription Factor		Regulated		Binding Sites				Evidence	References
Functional conformation	Function	Promoter	Gene(s)	LeftPos	RigthPos	Central Rel-Pos	Sequence
MarA	repressor	purAp	purA	4404611	4404630	-43.0	cgaggtcattTTTGAGTGCAAAAAGTGCTGtaactctgaa	[GEA]	[1]
PurR-hypoxanthine	repressor	purAp	purA	4404566	4404581	-90.5	ctacatgttgAGGAAAACGATTGGCTgaacaaaaaa	[GEA]	[2] [3]
PurR-hypoxanthine	repressor	purAp	purA	4404665	4404680	9.5	atccatttttAAGCAAACGGTGATTTtgaaaaatgg	[GEA]	[2] [3]
GadE	activator	purAp	purA

Evidence:	[GEA] Gene expression analysis
Reference(s):	[1] Schneiders T., et al., 2004 [2] Cho BK., et al., 2011 [3] He B., et al., 1994

Reference(s)
[1] Schneiders T., Barbosa TM., McMurry LM., Levy SB., 2004, The Escherichia coli transcriptional regulator MarA directly represses transcription of purA and hdeA., J Biol Chem 279(10):9037-42
[2] Cho BK., Federowicz SA., Embree M., Park YS., Kim D., Palsson BO., 2011, The PurR regulon in Escherichia coli K-12 MG1655., Nucleic Acids Res 39(15):6456-64
[3] He B., Zalkin H., 1994, Regulation of Escherichia coli purA by purine repressor, one component of a dual control mechanism., J Bacteriol 176(4):1009-13
[4] Hommais F., Krin E., Coppee JY., Lacroix C., Yeramian E., Danchin A., Bertin P., 2004, GadE (YhiE): a novel activator involved in the response to acid environment in Escherichia coli., Microbiology 150(Pt 1):61-72