RegulonDB

TRANSCRIPTION FACTOR:

Name:

FabR	Tractordb tool

Connectivity class

Local Regulator

Synonym(s):

DNA-binding transcriptional repressor FabR, YijC

Gene name(s):

fabR

Functional conformation(s):

FabR

Coregulator(s):

FabR, FadR

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Name:

FadR	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Sensing Class

Using internal synthesized signals

Synonym(s):

DNA-binding transcriptional dual regulator FadR, Dec, Ole, OleR, ThdB

Gene name(s):

fadR

Functional conformation(s):

FadR-an acyl-CoA , FadR

Coregulator(s):

ArcA, CRP, DksA-ppGpp, FabR, FadR, Fis, HipB, IHF, IclR, OmpR, PhoP, Rob, ppGpp

Summary:

TF Summary ...[more]

REGULATION EXERTED BY FabR,FadR

Info M3D | Colombos

KNOWN BINDING SITES (The central relative position is relative to the promoter +1)
FabR repressor FadR activator
Transcription Factor		Regulated		Binding Sites				Evidence	References
Functional conformation	Function	Promoter	Gene(s)	LeftPos	RigthPos	Central Rel-Pos	Sequence
FadR	activator	fabAp	fabA	1016528	1016544	-38.0	gtttattccgAACTGATCGGACTTGTTcagcgtacac	[GEA]	[1]
FabR	repressor	fabAp	fabA	1016509	1016526	-19.5	ggacttgttcAGCGTACACGTGTTAGCTatcctgcgtg	[GEA]	[1] [2] [3]
FadR	activator	fabBp	fabB	2441672	2441688	-39.0	tctattaaatGGCTGATCGGACTTGTTcggcgtacaa	[GEA]	[4] [1]
FabR	repressor	fabBp	fabB	2441653	2441670	-20.5	ggacttgttcGGCGTACAAGTGTACGCTattgtgcatt	[GEA]	[1] [2] [3]

Evidence:	[GEA] Gene expression analysis
Reference(s):	[1] Feng Y., et al., 2011 [2] McCue L., et al., 2001 [3] Zhang YM., et al., 2002 [4] Campbell JW., et al., 2001

Reference(s)
[1] Feng Y., Cronan JE., 2011, Complex binding of the FabR repressor of bacterial unsaturated fatty acid biosynthesis to its cognate promoters., Mol Microbiol 80(1):195-218
[2] McCue L., Thompson W., Carmack C., Ryan MP., Liu JS., Derbyshire V., Lawrence CE., 2001, Phylogenetic footprinting of transcription factor binding sites in proteobacterial genomes., Nucleic Acids Res 29(3):774-82
[3] Zhang YM., Marrakchi H., Rock CO., 2002, The FabR (YijC) transcription factor regulates unsaturated fatty acid biosynthesis in Escherichia coli., J Biol Chem 277(18):15558-65
[4] Campbell JW., Cronan JE., 2001, Escherichia coli FadR positively regulates transcription of the fabB fatty acid biosynthetic gene., J Bacteriol 183(20):5982-90