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FabR,FadR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
FabR      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional repressor FabR, YijC
Gene name(s): fabR
Functional conformation(s): FabR
Coregulator(s): FabR, FadR
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
FadR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator FadR, Dec, Ole, OleR, ThdB
Gene name(s): fadR
Functional conformation(s): FadR-an acyl-CoA , FadR
Coregulator(s): ArcA, CRP, DksA-ppGpp, FabR, FadR, Fis, HipB, IHF, IclR, OmpR, PhoP, Rob, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY FabR,FadR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
FabR repressor FadR activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
FadR activator fabAp fabA 1016528 1016544 -38.0 gtttattccgAACTGATCGGACTTGTTcagcgtacac [GEA] [1]
FabR repressor fabAp fabA 1016509 1016526 -19.5 ggacttgttcAGCGTACACGTGTTAGCTatcctgcgtg [GEA] [1]
[2]
[3]
FadR activator fabBp fabB 2441672 2441688 -39.0 tctattaaatGGCTGATCGGACTTGTTcggcgtacaa [GEA] [4]
[1]
FabR repressor fabBp fabB 2441653 2441670 -20.5 ggacttgttcGGCGTACAAGTGTACGCTattgtgcatt [GEA] [1]
[2]
[3]

Evidence: [GEA] Gene expression analysis
Reference(s): [1] Feng Y., et al., 2011
[2] McCue L., et al., 2001
[3] Zhang YM., et al., 2002
[4] Campbell JW., et al., 2001



Reference(s)    

 [1] Feng Y., Cronan JE., 2011, Complex binding of the FabR repressor of bacterial unsaturated fatty acid biosynthesis to its cognate promoters., Mol Microbiol 80(1):195-218

 [2] McCue L., Thompson W., Carmack C., Ryan MP., Liu JS., Derbyshire V., Lawrence CE., 2001, Phylogenetic footprinting of transcription factor binding sites in proteobacterial genomes., Nucleic Acids Res 29(3):774-82

 [3] Zhang YM., Marrakchi H., Rock CO., 2002, The FabR (YijC) transcription factor regulates unsaturated fatty acid biosynthesis in Escherichia coli., J Biol Chem 277(18):15558-65

 [4] Campbell JW., Cronan JE., 2001, Escherichia coli FadR positively regulates transcription of the fabB fatty acid biosynthetic gene., J Bacteriol 183(20):5982-90


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