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BtsR,CpxR,CsgD,FliZ regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CpxR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): CpxR response regulator, DNA-binding transcriptional dual regulator CpxR, YiiA
Gene name(s): cpxR
Functional conformation(s): CpxR-phosphorylated , CpxR
Coregulator(s): AcrR, BaeR, BasR, BolA, BtsR, CRP, CpxR, Cra, CsgD, CysB, EnvY, Fis, FliZ, Fur, GadE, H-NS, IHF, Lrp, MarA, MarR, MlrA, MqsA, NsrR, OmpR, PdhR, PhoB, RcdA, RcsAB, RcsB, Rob, RstA, SoxS, TyrR, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
CsgD Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator CsgD
Gene name(s): csgD
Functional conformation(s): CsgD
Coregulator(s): BasR, BolA, BtsR, CRP, CpxR, Cra, CsgD, DksA-ppGpp, FlhDC, FliZ, H-NS, IHF, MatA, MlrA, MqsA, NsrR, OmpR, PdeL, RcdA, RcsAB, RstA, SutR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
FliZ      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional regulator FliZ, YedH
Gene name(s): fliZ
Functional conformation(s): FliZ
Coregulator(s): AcrR, AdiY, BasR, BolA, BtsR, CRP, CpxR, Cra, CsgD, EvgA, Fis, FliZ, Fur, GadE, GadW, GadX, H-NS, HdfR, IHF, LrhA, Lrp, MarA, MatA, MlrA, MqsA, OmpR, PhoP, QseB, RcdA, RcsAB, RcsB, RstA, RutR, TorR, YdeO, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
BtsR      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional dual regulator BtsR, YehT
Gene name(s): btsR
Functional conformation(s): BtsR-Phosphorylated , BtsR
Coregulator(s): ArcA, BasR, BolA, BtsR, CRP, CpxR, Cra, CsgD, DpiA, FNR, FlhDC, FliZ, H-NS, IHF, MlrA, MqsA, OmpR, PdhR, RcdA, RcsAB, RstA, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY BtsR,CpxR,CsgD,FliZ Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
BtsR repressor CpxR repressor CsgD activator FliZ repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CsgD activator csgBp csgB , csgA , csgC 1103816 1103826 -38.0 atacaacgcgCGGGTGAGTTAttaaaaatat [GEA] [1]
CpxR-phosphorylated repressor csgBp csgB , csgA , csgC 1103859 1103873 8.0 actttccatcGTAACGCAGCGTTAAcaaaatacag [GEA] [2]
[3]
CsgD activator csgBp csgB , csgA , csgC 1103825 1103839 -27.5 gcgggtgagtTATTAAAAATATTTCcgcagacata [GEA] [4]
CsgD activator csgBp csgB , csgA , csgC 1103795 1103809 -57.5 ggtatgaactAAAAAAGAAAAATACaacgcgcggg [GEA] [4]
CsgD activator csgBp csgB , csgA , csgC 1103772 1103786 -80.5 atttacgtggGTTTTAATACTTTGGtatgaactaa [GEA] [4]
CpxR-phosphorylated repressor csgBp csgB , csgA , csgC 1103388 1103402 -464.0 gtgttaaacaTGTAACTAAATGTAActcgttatat [GEA] [3]
CpxR-phosphorylated repressor csgBp csgB , csgA , csgC 1103597 1103611 -255.0 cacacctccgTGGACAATTTTTTACtgcaaaaaga   [2]
FliZ repressor csgBp csgB , csgA , csgC

Evidence: [GEA] Gene expression analysis
Reference(s): [1] Brombacher E., et al., 2003
[2] De Wulf P., et al., 2002
[3] Prigent-Combaret C., et al., 2001
[4] Ogasawara H., et al., 2011



Reference(s)    

 [1] Brombacher E., Dorel C., Zehnder AJ., Landini P., 2003, The curli biosynthesis regulator CsgD co-ordinates the expression of both positive and negative determinants for biofilm formation in Escherichia coli., Microbiology 149(Pt 10):2847-57

 [2] De Wulf P., McGuire AM., Liu X., Lin EC., 2002, Genome-wide profiling of promoter recognition by the two-component response regulator CpxR-P in Escherichia coli., J Biol Chem 277(29):26652-61

 [3] Prigent-Combaret C., Brombacher E., Vidal O., Ambert A., Lejeune P., Landini P., Dorel C., 2001, Complex regulatory network controls initial adhesion and biofilm formation in Escherichia coli via regulation of the csgD gene., J Bacteriol 183(24):7213-23

 [4] Ogasawara H., Yamamoto K., Ishihama A., 2011, Role of the biofilm master regulator CsgD in cross-regulation between biofilm formation and flagellar synthesis., J Bacteriol 193(10):2587-97

 [5] Pesavento C., Becker G., Sommerfeldt N., Possling A., Tschowri N., Mehlis A., Hengge R., 2008, Inverse regulatory coordination of motility and curli-mediated adhesion in Escherichia coli., Genes Dev 22(17):2434-46

 [6] Ogasawara H., Ishizuka T., Yamaji K., Kato Y., Shimada T., Ishihama A., 2019, Regulatory role of pyruvate-sensing BtsSR in biofilm formation by Escherichia coli K-12., FEMS Microbiol Lett 366(24)

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