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NagC regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
NagC Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External sensing using transported metabolites
Synonym(s): DNA-binding transcriptional dual regulator NagC, NagR, transcriptional repressor of nag (N-acetylglucosamine) operon
Gene name(s): nagC
Functional conformation(s): NagC , NagC-N-acetyl-D-glucosamine 6-phosphate
Coregulator(s): AraC, BasR, CRP, ChbR, Cra, DksA, DksA-ppGpp, EvgA, FNR, Fur, GadX, GalR, GalS, H-NS, IHF, LexA, Mlc, NagC, NanR, NarL, NarP, OmpR, PhoP, RcsB, UvrY, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY NagC Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
NagC repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
NagC repressor glmUp2 glmS , glmU 3915258 3915280 58.0 ttatcctctgTCCATTTCACGATGAAAAAAATGtagttttttc   [1]
NagC repressor glmUp2 glmS , glmU 3915411 3915433 -96.0 ctgttttcctGTTTATTCATTGATCGAAATAAGagcaaaaaca   [1]
NagC repressor creAp creA , creB , creC , creD 4635467 4635489 2.0 taatcaatatGTTATTTACCGTGACGAACTAATtgctcgtgta    
NagC repressor ptsHp3 ptsH , ptsI , crr 2533502 2533524 7.0 aaccagactaATTATTTTGATGCGCGAAATTAAtcgttacagg [AIBSCS] [2]
NagC activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
NagC activator glmUp1 glmS , glmU 3915258 3915280 -46.0 ttatcctctgTCCATTTCACGATGAAAAAAATGtagttttttc   [1]
NagC activator glmUp1 glmS , glmU 3915411 3915433 -199.0 ctgttttcctGTTTATTCATTGATCGAAATAAGagcaaaaaca   [1]

Evidence: [AIBSCS] Automated inference based on similarity to consensus sequences
Reference(s): [1] Plumbridge J. 1995
[2] Oberto J. 2010



Reference(s)    

 [1] Plumbridge J., 1995, Co-ordinated regulation of amino sugar biosynthesis and degradation: the NagC repressor acts as both an activator and a repressor for the transcription of the glmUS operon and requires two separated NagC binding sites., EMBO J 14(16):3958-65

 [2] Oberto J., 2010, FITBAR: a web tool for the robust prediction of prokaryotic regulons., BMC Bioinformatics 11:554


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