RegulonDB RegulonDB 10.10: Regulon Form
   
   


ArcA,GlcC,IHF,PdhR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
ArcA Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class External-Two-component systems
Synonym(s): ArcA response regulator, CpxC, DNA-binding transcriptional dual regulator ArcA, Dye, FexA, Msp, Seg, SfrA, dye resistance protein
Gene name(s): arcA
Functional conformation(s): ArcA-phosphorylated , ArcA
Coregulator(s): AdiY, AppY, ArcA, BetI, BtsR, CRP, CadC, CaiF, Cra, CusR, CysB, DcuR, DksA-ppGpp, DnaA, DpiA, FNR, FadR, Fis, FlhDC, Fur, GadE, GadE-RcsB, GadW, GadX, GatR, GlcC, GlpR, H-NS, HipB, HprR, HypT, IHF, IclR, IscR, LexA, LldR, Lrp, MarA, McbR, Mlc, ModE, MqsA, NarL, NarP, NsrR, NtrC, OmpR, PdhR, PhoP, PuuR, RcdA, RcsB, RhaS, Rob, RutR, SdiA, SlyA, SoxR, SoxS, TorR, TreR, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
GlcC      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional dual regulator GlcC, YghN
Gene name(s): glcC
Functional conformation(s): GlcC-glycolate , GlcC-Acetate , GlcC
Coregulator(s): ArcA, CRP, Cra, Fis, GlcC, IHF, PdhR
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
PdhR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): AceC, DNA-binding transcriptional dual regulator PdhR, GenA, YacB
Gene name(s): pdhR
Functional conformation(s): PdhR-pyruvate , PdhR
Coregulator(s): ArcA, AscG, BasR, BtsR, CRP, CpxR, Cra, CusR, FNR, Fis, Fur, GadE, GlcC, HprR, HypT, IHF, MraZ, NsrR, PdhR, PhoP
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
IHF Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): DNA-binding transcriptional dual regulator IHF
Gene name(s): ihfB, ihfA
Functional conformation(s): IHF
Coregulator(s): AcrR, AdiY, ArcA, ArgR, AtoC, BasR, BolA, BtsR, CRP, Cbl, CpxR, Cra, CsgD, CysB, DksA, DksA-ppGpp, EnvY, FNR, FadR, FhlA, Fis, FlhDC, FliZ, Fur, GadE, GlcC, GlpR, GlrR, H-NS, HU, HdfR, HipAB, HipB, IHF, IclR, IscR, LrhA, Lrp, MarA, MatA, MlrA, MntR, ModE, MprA, MqsA, Nac, NagC, NanR, NarL, NarP, NorR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PepA, PhoB, PlaR, PspF, PurR, QseB, RcdA, RcsAB, Rob, RstA, RtcR, RutR, SlyA, SoxR, SoxS, SutR, TdcA, TdcR, TrpR, TyrR, UlaR, UvrY, YeiL, YjjQ, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY ArcA,GlcC,IHF,PdhR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
ArcA repressor GlcC activator IHF activator PdhR repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
IHF activator glcDp glcA , glcB , glcG , glcF , glcE , glcD 3128177 3128189 -107.0 attatgttacATCAATTTAACATtgagttaacc [GEA] [1]
GlcC-glycolate activator glcDp glcA , glcB , glcG , glcF , glcE , glcD 3128245 3128259 -176.0 ccggacctcgTGCACAGGTAGGACCaatttttctg [GEA] [1]
ArcA-phosphorylated repressor glcDp glcA , glcB , glcG , glcF , glcE , glcD 3128173 3128187 -104.0 tatgttacatCAATTTAACATTGAGttaaccaaga [GEA] [2]
[1]
ArcA-phosphorylated repressor glcDp glcA , glcB , glcG , glcF , glcE , glcD 3128180 3128194 -111.0 aagtgattatGTTACATCAATTTAAcattgagtta [GEA] [1]
PdhR repressor glcDp glcA , glcB , glcG , glcF , glcE , glcD 3128124 3128140 -56.0 gctggaaaaaAAATGGTCTGACCGGTAgctaaagaga [GEA] [3]

Evidence: [GEA] Gene expression analysis
Reference(s): [1] Pellicer MT., et al., 1999
[2] Liu X., et al., 2004
[3] Gohler AK., et al., 2011



Reference(s)    

 [1] Pellicer MT., Fernandez C., Badia J., Aguilar J., Lin EC., Baldom L., 1999, Cross-induction of glc and ace operons of Escherichia coli attributable to pathway intersection. Characterization of the glc promoter., J Biol Chem 274(3):1745-52

 [2] Liu X., De Wulf P., 2004, Probing the ArcA-P modulon of Escherichia coli by whole genome transcriptional analysis and sequence recognition profiling., J Biol Chem 279(13):12588-97

 [3] Gohler AK., Kokpinar O., Schmidt-Heck W., Geffers R., Guthke R., Rinas U., Schuster S., Jahreis K., Kaleta C., 2011, More than just a metabolic regulator - elucidation and validation of new targets of PdhR in Escherichia coli., BMC Syst Biol 5(1):197

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