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SoxR,TyrR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
TyrR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional dual regulator TyrR
Gene name(s): tyrR
Functional conformation(s): TyrR , TyrR-L-tyrosine , TyrR-L-phenylalanine , TyrR-L-tryptophan
Coregulator(s): CpxR, Cra, HU, IHF, PgrR, SoxR, TrpR, TyrR
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
SoxR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator SoxR, MarC
Gene name(s): soxR
Functional conformation(s): SoxR , SoxR-[2Fe-2S]3+ oxydized , SoxR-[2Fe-2S]2+ reduced
Coregulator(s): AcrR, ArcA, BasR, CRP, FNR, Fur, IHF, MarA, PhoP, Rob, SoxR, SoxS, TyrR
Summary: TF Summary ...[more]

REGULATION EXERTED BY SoxR,TyrR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
SoxR activator TyrR repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
TyrR-L-tyrosine repressor aroFp tyrA , aroF 2741297 2741314 -104.5 tcaaagggagTGTAAATTTATCTATACAgaggtaaggg [GEA] [1]
[2]
[3]
TyrR-L-tyrosine repressor aroFp tyrA , aroF 2741245 2741262 -52.5 aaattgcctgTGTAAATAAAAATGTACGaaatatggat [GEA] [1]
[2]
[3]
TyrR-L-tyrosine repressor aroFp tyrA , aroF 2741222 2741239 -29.5 gtacgaaataTGGATTGAAAACTTTACTttatgtgtta [GEA] [1]
[2]
[4]
[3]
SoxR activator aroFp tyrA , aroF 2741185 2741202 8.5 atcgttacgtCATCCTCGCTGAGGATCAactatcgcaa [RSE] [5]

Evidence: [GEA] Gene expression analysis
[RSE] RNA-seq evidence
Reference(s): [1] Cobbett CS. 1988
[2] Cobbett CS., et al., 1987
[3] Garner CC., et al., 1985
[4] DeFeyter RC., et al., 1986
[5] Seo SW., et al., 2015



Reference(s)    

 [1] Cobbett CS., 1988, Repression of the aroF promoter by the TyrR repressor in Escherichia coli K-12: role of the 'upstream' operator site., Mol Microbiol 2(3):377-83

 [2] Cobbett CS., Delbridge ML., 1987, Regulatory mutants of the aroF-tyrA operon of Escherichia coli K-12., J Bacteriol 169(6):2500-6

 [3] Garner CC., Herrmann KM., 1985, Operator mutations of the Escherichia coli aroF gene., J Biol Chem 260(6):3820-5

 [4] DeFeyter RC., Davidson BE., Pittard J., 1986, Nucleotide sequence of the transcription unit containing the aroL and aroM genes from Escherichia coli K-12., J Bacteriol 165(1):233-9

 [5] Seo SW., Kim D., Szubin R., Palsson BO., 2015, Genome-wide Reconstruction of OxyR and SoxRS Transcriptional Regulatory Networks under Oxidative Stress in Escherichia coli K-12 MG1655., Cell Rep 12(8):1289-99


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