RegulonDB

TRANSCRIPTION FACTOR:

Name:

OxyR	Tractordb tool

Connectivity class

Local Regulator

Sensing Class

Using internal synthesized signals

Synonym(s):

DNA-binding transcriptional dual regulator OxyR, MomR, Mor, bifunctional regulatory protein sensor for oxidative stress

Gene name(s):

oxyR

Functional conformation(s):

OxyR

Coregulator(s):

CRP, DksA, ExuR, FNR, Fis, Fur, H-NS, IHF, IscR, MarA, MetJ, MetR, MntR, NarL, NarP, NsrR, OxyR, Rob, SoxS, UxuR, YdcI, Zur, ppGpp

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

MetR	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Sensing Class

Using internal synthesized signals

Synonym(s):

DNA-binding transcriptional dual regulator MetR

Gene name(s):

metR

Functional conformation(s):

MetR , MetR-L-homocysteine

Coregulator(s):

FNR, Fur, MetJ, MetR, NsrR, OxyR, PurR, ppGpp

Summary:

TF Summary ...[more]

TRANSCRIPTION FACTOR:

Info

Name:

MetJ	Weight Matrix Tractordb tool

Connectivity class

Local Regulator

Sensing Class

Using internal synthesized signals

Synonym(s):

DNA-binding transcriptional repressor MetJ

Gene name(s):

metJ

Functional conformation(s):

MetJ-S-adenosyl-L-methionine , MetJ-MTA , MetJ-adenine , MetJ

Coregulator(s):

CRP, HypT, MetJ, MetR, OxyR, PhoP

Summary:

TF Summary ...[more]

REGULATION EXERTED BY MetJ,MetR,OxyR

Info M3D | Colombos

KNOWN BINDING SITES (The central relative position is relative to the promoter +1)
MetJ repressor MetR activator OxyR activator
Transcription Factor		Regulated		Binding Sites				Evidence	References
Functional conformation	Function	Promoter	Gene(s)	LeftPos	RigthPos	Central Rel-Pos	Sequence
MetR-L-homocysteine	activator	metEp	metE	4012815	4012829	-62.0	tacttcgatcATGAAAGTCCTTCACttcggcatga	[GEA]	[1] [2] [3] [4]
MetJ-S-adenosyl-L-methionine	repressor	metEp	metE	4012992	4013007	116.5	ggatgaataaACTTGCCGCCTTCCCTaaattcaaaa		[1]
MetJ-S-adenosyl-L-methionine	repressor	metEp	metE	4012877	4012892	1.5	aaccgccaatTATGGATGTGTAAACAtctggacggc		[1]
MetR-L-homocysteine	activator	metEp	metE	4012836	4012850	-41.0	tcacttcggcATGAATAATTTGCGCttgaggaata	[GEA]	[1] [2] [3] [4]
OxyR	activator	metEp	metE	4012834	4012850	-42.0	cttcacttcgGCATGAATAATTTGCGCttgaggaata	[RSE]	[5]
MetJ repressor MetR repressor OxyR activator
Transcription Factor		Regulated		Binding Sites				Evidence	References
Functional conformation	Function	Promoter	Gene(s)	LeftPos	RigthPos	Central Rel-Pos	Sequence
MetR-L-homocysteine	repressor	metRp1	metR	4012815	4012829	34.0	tcatgccgaaGTGAAGGACTTTCATgatcgaagta	[GEA]	[1] [2] [3] [4]
MetJ-S-adenosyl-L-methionine	repressor	metRp1	metR	4012992	4013007	-144.5	ttttgaatttAGGGAAGGCGGCAAGTttattcatcc		[1]
MetJ-S-adenosyl-L-methionine	repressor	metRp1	metR	4012877	4012892	-29.5	gccgtccagaTGTTTACACATCCATAattggcggtt		[1]
MetR-L-homocysteine	repressor	metRp1	metR	4012836	4012850	13.0	tattcctcaaGCGCAAATTATTCATgccgaagtga	[BPP] [GEA]	[1] [2] [3] [4]
OxyR	activator	metRp1	metR	4012852	4012868	-5.0	taattggcggTTACTGTATATTCCTCAagcgcaaatt	[RSE]	[5]

Evidence:	[GEA] Gene expression analysis [RSE] RNA-seq evidence [BPP] Binding of purified proteins
Reference(s):	[1] Cai XY., et al., 1989 [2] Cai XY., et al., 1989 [3] Jafri S., et al., 1995 [4] Maxon ME., et al., 1989 [5] Seo SW., et al., 2015

Reference(s)
[1] Cai XY., Maxon ME., Redfield B., Glass R., Brot N., Weissbach H., 1989, Methionine synthesis in Escherichia coli: effect of the MetR protein on metE and metH expression., Proc Natl Acad Sci U S A 86(12):4407-11
[2] Cai XY., Redfield B., Maxon M., Weissbach H., Brot N., 1989, The effect of homocysteine on MetR regulation of metE, metR and metH expression in vitro., Biochem Biophys Res Commun 163(1):79-83
[3] Jafri S., Urbanowski ML., Stauffer GV., 1995, A mutation in the rpoA gene encoding the alpha subunit of RNA polymerase that affects metE-metR transcription in Escherichia coli., J Bacteriol 177(3):524-9
[4] Maxon ME., Redfield B., Cai XY., Shoeman R., Fujita K., Fisher W., Stauffer G., Weissbach H., Brot N., 1989, Regulation of methionine synthesis in Escherichia coli: effect of the MetR protein on the expression of the metE and metR genes., Proc Natl Acad Sci U S A 86(1):85-9
[5] Seo SW., Kim D., Szubin R., Palsson BO., 2015, Genome-wide Reconstruction of OxyR and SoxRS Transcriptional Regulatory Networks under Oxidative Stress in Escherichia coli K-12 MG1655., Cell Rep 12(8):1289-99