RegulonDB RegulonDB 10.10: Regulon Form
   
   


BaeR,CpxR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CpxR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): CpxR response regulator, DNA-binding transcriptional dual regulator CpxR, YiiA
Gene name(s): cpxR
Functional conformation(s): CpxR-phosphorylated , CpxR
Coregulator(s): AcrR, BaeR, BasR, BolA, BtsR, CRP, CpxR, Cra, CsgD, CysB, EnvY, Fis, FliZ, Fur, GadE, H-NS, IHF, Lrp, MarA, MarR, MlrA, MqsA, NsrR, OmpR, PdhR, PhoB, RcdA, RcsAB, RcsB, Rob, RstA, SoxS, TyrR, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
BaeR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): BaeR response regulator, DNA-binding transcriptional activator BaeR
Gene name(s): baeR
Functional conformation(s): BaeR , BaeR-phosphorylated
Coregulator(s): BaeR, CpxR
Summary: TF Summary ...[more]

REGULATION EXERTED BY BaeR,CpxR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
BaeR activator CpxR activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CpxR-phosphorylated activator spyp spy 1825731 1825745 -50.0 gttttttacaCTTTCATTGTTTTACcgttgctctg [GEA] [1]
[2]
[3]
[4]
BaeR-phosphorylated activator spyp spy 1825765 1825784 -86.5 atcaaattttCTTTTTTTCTCCATAATTGGcgcaaaagtg [GEA] [5]
[1]
[6]
BaeR-phosphorylated activator spyp spy 1825836 1825855 -157.5 ccagtcatccGGTATAGTTCTTCATAATCTctgcaaaatc [IC] [6]
BaeR-phosphorylated activator mdtAp mdtA , mdtB , mdtC , mdtD , baeS , baeR 2153942 2153961 -27.5 cataattcctCCATTTTTCTCCCTTATTGGctggctacac [GEA] [7]
[8]
[5]
CpxR-phosphorylated activator acrDp2 acrD 2587476 2587493 -66.0 ggttcagtatAAAAGGGCATGATAATTTacattaactc [GEA]
[IC] 		[7]
CpxR-phosphorylated activator acrDp2 acrD 2587446 2587459 -98.0 tcctactgacCAAAGAATACTTGCacttaaggtt [IC] [7]
CpxR-phosphorylated activator mdtAp mdtA , mdtB , mdtC , mdtD , baeS , baeR 2153906 2153920 -66.5 atgtgcccgtCATTCAGACGATTCCagacagtgtt [GEA]
[IC] 		[7]
BaeR-phosphorylated activator acrDp2 acrD 2587504 2587523 -36.5 acattaactcCTTTTTTTCTCCACGATTGGctcgtacctt [GEA]
[IC] 		[7]
CpxR-phosphorylated activator mdtAp mdtA , mdtB , mdtC , mdtD , baeS , baeR 2153843 2153859 -128.5 cagtctatcgCTAACGCGTAGATAAAAtagtttcctg [GEA]
[IC] 		[7]
CpxR-phosphorylated activator acrDp2 acrD 2587414 2587432 -127.5 ggagggtgagGAAAGTCAGTTAATGTAATgcctcctact [GEA]
[IC] 		[7]

Evidence: [GEA] Gene expression analysis
[IC] Inferred by curator
Reference(s): [1] Raffa RG., et al., 2002
[2] Raivio TL., et al., 2000
[3] Raivio TL., et al., 2013
[4] Yamamoto K., et al., 2006
[5] Nishino K., et al., 2005
[6] Yamamoto K., et al., 2008
[7] Hirakawa H., et al., 2005
[8] Nagakubo S., et al., 2002



Reference(s)    

 [1] Raffa RG., Raivio TL., 2002, A third envelope stress signal transduction pathway in Escherichia coli., Mol Microbiol 45(6):1599-611

 [2] Raivio TL., Laird MW., Joly JC., Silhavy TJ., 2000, Tethering of CpxP to the inner membrane prevents spheroplast induction of the cpx envelope stress response., Mol Microbiol 37(5):1186-97

 [3] Raivio TL., Leblanc SK., Price NL., 2013, The Escherichia coli Cpx envelope stress response regulates genes of diverse function that impact antibiotic resistance and membrane integrity., J Bacteriol 195(12):2755-67

 [4] Yamamoto K., Ishihama A., 2006, Characterization of copper-inducible promoters regulated by CpxA/CpxR in Escherichia coli., Biosci Biotechnol Biochem 70(7):1688-95

 [5] Nishino K., Honda T., Yamaguchi A., 2005, Genome-wide analyses of Escherichia coli gene expression responsive to the BaeSR two-component regulatory system., J Bacteriol 187(5):1763-72

 [6] Yamamoto K., Ogasawara H., Ishihama A., 2008, Involvement of multiple transcription factors for metal-induced spy gene expression in Escherichia coli., J Biotechnol 133(2):196-200

 [7] Hirakawa H., Inazumi Y., Masaki T., Hirata T., Yamaguchi A., 2005, Indole induces the expression of multidrug exporter genes in Escherichia coli., Mol Microbiol 55(4):1113-26

 [8] Nagakubo S., Nishino K., Hirata T., Yamaguchi A., 2002, The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC., J Bacteriol 184(15):4161-7

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